Pango lineage designation and assignment using SARS-CoV-2 spike gene nucleotide sequencesSARS-COV-2 스파이크 유전자 뉴클레오티드 서열을 사용한 판고 계통 지정 및 할당Research Article Published on 2022-02-112022-09-10 Journal: BMC Genomics [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] Analysis assigned classification Complete COVID-19 pandemic Disease surveillance facilitate foundation genetic diversity Genomic surveillance Health policy information Lineage lineages Mutation nucleotide nucleotide sequence outbreak Pango Precision public health Result SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 lineage SARS-CoV-2 spike sequence spike spike gene supplementary material These data variants variants of concern virus genomes [DOI] 10.1186/s12864-022-08358-2 PMC 바로가기 [Article Type] Research Article
Alu RNA Structural Features Modulate Immune Cell Activation and A-to-I Editing of Alu RNAs Is Diminished in Human Inflammatory Bowel DiseaseImmunology Published on 2022-01-202022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] A-to-I editing activate Altering Alu Alu RNA Analysis Autoimmune disease biological activity Cell Consequences COVID-19 Deamination Degradation demonstrated diminished disrupt double-stranded RNA dsRNA dsRNAs element form Human human disease include increase inflammatory bowel diseases Influenza inhibit innate immune activation innate immune response Inosine IRF IRF responses leukocyte multiple sclerosis NF-kB NF-kB responses nuclear nucleotide sequence Prevent retrotransposon RIG-I RNA RNA binding proteins RNAs SINE stimulate structure-function therapeutic potential transcriptional activity viral disease widespread [DOI] 10.3389/fimmu.2022.818023 PMC 바로가기 [Article Type] Immunology
Typing of alpha and beta coronaviruses by DNA barcoding of NSP12 geneResearch Article Published on 2022-01-112022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] 229E acute respiratory syndrome Alpha Amplicon sequencing amplification amplify applied bat beta coronavirus coding sequence conserved coronavirus Coronaviruses CoV COVID‐19 CoVs DNA DNA bar code Evolution facilitate Host hosts human CoV in silico indicated involved lab Lineage mammal MERS Molecular typing mutant NL63 nucleotide sequence OC43 pandemic pathogenicity Phylogenetic tree resulting SARS‐CoV‐2 sequence Spread taxonomy Transmission typing universal primer variant [DOI] 10.1002/jmv.27550 PMC 바로가기 [Article Type] Research Article
Explorative assessment of coronavirus-like short sequences from host-associated and environmental metagenomes숙주 관련 및 환경 메타게놈에서 코로나바이러스와 유사한 짧은 서열의 탐색적 평가Article Published on 2021-11-012022-09-11 Journal: The Science of the total environment [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] aggravate Analysis analyzed approaches caused Coronaviruses COVID-19 COVID-19 pandemic data interpretation dataset datasets Deepening DNA sequence expand healthcare Host indicated knowledge metagenome metagenomic metagenomics Natural environment nucleotide nucleotide sequence parameter Previous studies previous study SARS-CoV-2 selected sequence situation terrestrial Virome profiling. virus detection [DOI] 10.1016/j.scitotenv.2021.148494 PMC 바로가기 [Article Type] Article
Therapeutic perceptions in antisense RNA-mediated gene regulation for COVID-19COVID-19에 대한 안티센스 RNA 매개 유전자 조절의 치료적 인식Article Published on 2021-10-202022-09-11 Journal: Gene [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Algorithm antisense Antisense RNA base Biotechnology BLAST center Complete coronavirus COVID-19 dataset disease downloaded effective therapy effective vaccine Effective vaccines Gene regulation hybridizing identify input marker mechanism MERS MERS-CoV money normality nucleotide nucleotide sequence nucleotides occur ORF1ab platform Regulation reported Repository Research RNA Safe SARS-CoV SARS-CoV-2 sequence Sequence 2 sequences severe acute respiratory syndrome Coronavirus single-stranded strain therapeutic therapy translation treat vaccination Vaccine Wuhan Wuhan, China [DOI] 10.1016/j.gene.2021.145839 PMC 바로가기 [Article Type] Article
The first case study of wastewater-based epidemiology of COVID-19 in Hong Kong홍콩의 코로나19 폐수 기반 역학에 대한 첫 번째 사례 연구Article Published on 2021-10-102022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] addressed Characteristics collected coronavirus disease COVID-19 COVID-19 outbreak disease Early detection Early warnings effective Epidemiology highest Hong Kong hospital increasingly Isolation nucleotide nucleotide sequence Population SARS-CoV-2 SARS-CoV-2 virus Sequencing Severe acute respiratory syndrome sewage Sewage surveillance Sewage system characteristics. Sewage treatment Surveillance the SARS-CoV-2 treating COVID-19 patients Treatment viral titer virus was used [DOI] 10.1016/j.scitotenv.2021.148000 PMC 바로가기 [Article Type] Article
Global Prevalence of Adaptive and Prolonged Infections’ Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike ProteinSARS-COV-2 스파이크 단백질의 수용체 결합 도메인에서 적응 및 장기 감염의 돌연변이의 글로벌 유병률Article Published on 2021-09-302022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Administered coronavirus COVID-19 delta variant dominant dominant mutation E484K Effectiveness Efficacy followed by geographical region Host immune evasion infection control L452R less mAbs monoclonal antibodies monoclonal antibody Mutation mutations N439K N501Y NCBI database nucleotide nucleotide sequence Other Prevalence prevalent Prolonged Proofreading Protein RBD Receptor-binding domain reduce respiratory RNA-dependent RNA polymerase S477N SARS-CoV-2 SARS-CoV-2 infections severe acute respiratory syndrome Coronavirus spike Spike protein Spread T478K the receptor-binding domain the SARS-CoV-2 the spike protein Transmission V483A Vaccine variant variants variants of SARS-CoV-2 virus [DOI] 10.3390/v13101974 PMC 바로가기 [Article Type] Article
Quantifying bacterial evolution in the wild: A birthday problem for Campylobacter lineages야생에서 박테리아 진화를 정량화 : 캄 필로 박터 계통의 생일 문제Research Article Published on 2021-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy addition alteration Analysis approach approaches Bacteria Bacterial bacterium birthday problem Campylobacter Campylobacter jejuni clinical isolates CLOCK clock rate dataset DNA replication ecological effective estimates estimation event Evolution focus gastroenteritis gene transfer Genome genomic growth help horizontal gene Horizontal gene transfer Host humans identifying infect information introduced isolates lead Lineage lineages maintenance molecular molecular evolution Non-synonymous not applicable nucleotide nucleotide change nucleotide changes nucleotide sequence organism outbreak pathogen pathogenic bacteria pathogenic strains Pathogens Population Probability provide reducing reflect Region reproduction robust sampling selected Spread strain Strains synonymous toolkit transfer Transmission turnover Variation [DOI] 10.1371/journal.pgen.1009829 PMC 바로가기 [Article Type] Research Article
An in-depth in silico and immunoinformatics approach for designing a potential multi-epitope construct for the effective development of vaccine to combat against SARS-CoV-2 encompassing variants of concern and interest우려 및 관심의 변이를 포함하는 SARS-CoV-2에 대항하는 백신의 효과적인 개발을 위한 잠재적인 다중 에피토프 구성을 설계하기 위한 심층 실리코 및 면역정보학 접근 방식Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Antibody titer antigenicity approach B cell B cell epitope B-cell epitope B.1.1.7 B.1.351 B.1.427 B.1.429 B.1.526 B.1.617.1 B.1.617.2 binding Cell cells coronavirus COVID-19 effective elevated epitope Health immune response Immunity immunoinformatics in silico in vitro linker linkers MEV Multi-epitope vaccine NK cells nucleotide nucleotide sequence ORF1 ORF10 ORF1ab ORF3a ORF6 ORF7a ORF7b ORF8 outbreak P.1 P.2 Pathogens Physicochemical properties polyprotein present Prevent preventive measure receptor S protein SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell epitope T-cell the vaccine TLR2 TLR4 Toll-like receptor Toll-like receptors turn utility Vaccine vaccine construct variants variants of concern variants of interest variants of SARS-CoV-2 viral pathogen were used [DOI] 10.1016/j.compbiomed.2021.104703 PMC 바로가기 [Article Type] Article
Cospeciation of coronavirus and paramyxovirus with their bat hosts in the same geographical areasResearch Article Published on 2021-07-292022-10-28 Journal: BMC Ecology and Evolution [Category] COVID-19, [키워드] Analysis analyzed coevolution coronavirus coronavirus strain Cospeciation COVID-19 geographical area Hendra virus Host hosts Hypothesis investigated MERS Nipha virus nucleotide sequence paramyxovirus RdRP related viruses Result RNA polymerase RNA-dependent RNA polymerase SARS Significant specificity strain virus was tested [DOI] 10.1186/s12862-021-01878-7 PMC 바로가기 [Article Type] Research Article