Phylogenetic reconstruction of the initial stages of the spread of the SARS-CoV-2 virus in the Eurasian and American continents by analyzing genomic data게놈 데이터 분석을 통한 유라시아 및 미주 대륙의 SARS-CoV-2 바이러스 확산 초기 단계의 계통발생적 재구성Article Published on 2021-11-012022-09-11 Journal: Virus research [Category] SARS, 변종, 유전자 메커니즘, [키워드] America analyzed Asia Betacoronavirus characterized China CLOCK coding region comparable Complete coronavirus country COVID-19 COVID-19 pandemic enterovirus Europe Evolution Evolutionary rate First wave Genetic polymorphism Genome genomic data Genomics genus genus Betacoronavirus human population human RNA Infection initial Middle East molecular molecular clock nucleotide nucleotide substitution pathway Pathways Phylogenetic RaTG13 Result rubella rubella virus Sample SARS-CoV-2 SARS-CoV-2 genome separated Spread Stage the SARS-CoV-2 genome the SARS-CoV-2 virus virus virus spread [DOI] 10.1016/j.virusres.2021.198551 PMC 바로가기 [Article Type] Article
SARS-CoV-2 presented moderately during two episodes of the infection with lack of antibody responsesSARS-CoV-2는 항체 반응이 없는 두 번의 감염 에피소드 동안 적당히 나타남Case Reports Published on 2021-07-022022-09-11 Journal: Virus research [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Antibody Response caused change changes in clade Clade 20G clinical implication clinical implications coding coding regions COVID-19 Critical detectable effort episode of evaluated favor full recovery genomic genomic mutations IgG incidence Infection investigated lack lead Mutation mutation rate Mutation rates non-coding region nucleotide nucleotide mutation nucleotide mutations nucleotide substitution Occurrence Re-infection reference sequence Region reported RT-PCR SARS-CoV-2 Sequencing sequencing data significant effect specific antibodies specific antibody specific IgM subject Symptom the disease vaccination variant Viral viral genome viral sample viral samples virus was done [DOI] 10.1016/j.virusres.2021.198421 PMC 바로가기 [Article Type] Case Reports
Wastewater-based epidemiology as a useful tool to track SARS-CoV-2 and support public health policies at municipal level in BrazilSARS-CoV-2를 추적하고 브라질의 지방 자치 단체 수준에서 공중 보건 정책을 지원하는 유용한 도구로서의 폐수 기반 역학Article Published on 2021-03-012022-09-11 Journal: Water research [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition applied approach B.1.1.33 Brazil build clade collected complementary Concentration coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases effective Epidemic Epidemiology Evolution General population Genome Health heat map Illumina Miseq Indicator Intervention Lineage Local log municipality nucleotide nucleotide substitution nucleotide substitutions Occurrence plant populations positive rate positive rates primer Primers probe Public public health Public health policies quantified raising respiratory Rio de Janeiro RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus strain Strains Support Surveillance System Treatment ultracentrifugation was used wastewater Wastewater-based epidemiology whole-genome sequencing [DOI] 10.1016/j.watres.2021.116810 PMC 바로가기 [Article Type] Article
Challenges in estimating virus divergence times in short epidemic timescales with special reference to the evolution of SARS-CoV-2 pandemicArticles Published on 2021-02-082022-10-31 Journal: Genetics and Molecular Biology [Category] COVID-19, [키워드] Accuracy age Analysis can be used challenge coronavirus crown dataset Effectiveness Epidemic estimate evaluate evaluated Evolution Evolution of SARS-CoV-2 information interval nucleotide substitution pandemic parameter parameters Phylogeny Population populations provide public health SARS-CoV-2 SARS-CoV-2 pandemic Simulation time intervals Transmission tree shape tree topology virus virus transmission [DOI] 10.1590/1678-4685-GMB-2020-0254 PMC 바로가기 [Article Type] Articles
Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversityArticle Published on 2021-01-282022-10-30 Journal: iScience [Category] COVID-19, [키워드] ADAR adenosine affected Analysis APOBEC bioinformatics Clinical outcome Deaminase dissect dN/dS Frequency genetics Genome genomic Genotype heterogeneous highlighting homoplasy Host host response Hypothesis large-scale analysis mechanism MOST Mutation mutational processe nucleotide substitution phylogenetics profile purified respiratory reveal RNA ROS SARS-CoV-2 SARS-CoV-2 infections Specy Support Transmission Transmission dynamics transmitted variant variants [DOI] 10.1016/j.isci.2021.102116 PMC 바로가기 [Article Type] Article
Intranasal Infection of Ferrets with SARS-CoV-2 as a Model for Asymptomatic Human Infection무증상 인간 감염에 대한 모델로서 SARS-CoV-2를 사용한 흰 족제비의 비강 감염Article Published on 2021-01-152022-09-01 Journal: Viruses [Category] MERS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome amplify Analysis Antibody Response Antibody responses asymptomatic infection Cell coronavirus did not produce ferret ferrets genomic sequence host response Human humoral Humoral response infected with SARS-CoV-2 Infection inoculated inoculum intranasal Model nasal turbinates neuronal cells Neutralizing activity nucleoprotein nucleotide nucleotide substitution olfactory olfactory neuronal cells reached respiratory resulting RNA SARS-CoV-2 Severe acute respiratory syndrome subclinical infection Swab swabs tissues upper respiratory upper respiratory tract Viral Viral protein Viral RNA Viral RNA shedding virus-neutralizing Y453F [DOI] 10.3390/v13010113 PMC 바로가기 [Article Type] Article
Genomic characterization of SARS-CoV-2 identified in a reemerging COVID-19 outbreak in Beijing’s Xinfadi market in 2020Short communication Published on 2020-12-012022-10-05 Journal: Biosafety and Health [Category] 변종, [키워드] acute respiratory syndrome Amino acid Beijing caused characteristic Characteristics China clinical manifestations coronavirus coronavirus disease Course COVID-19 COVID-19 outbreak D614G mutation disease ENhance European full-length genome GenBank Genetic Genetic variation genome sequence genomes Genomic epidemiology help Human L-lineage European branch I likelihood MONITOR Mutation NC_045512 nucleotide nucleotide substitution outbreak Phylogenetic tree ranged reported SARS-CoV-2 SARS-CoV-2 genome sequenced severity similarity specimen Spread Substitution unique Viral transmission virus [DOI] 10.1016/j.bsheal.2020.08.006 [Article Type] Short communication
Comparative Genomic Analyses Reveal a Specific Mutation Pattern Between Human Coronavirus SARS-CoV-2 and Bat-CoV RaTG13Microbiology Published on 2020-11-302022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome amino acid substitution bat-CoV Bat-CoV RaTG13 codon codon usage Comparative Comparisons comprehensive analysis contribute coronavirus Coronaviruses dN/dS Evolution explain Genome global pandemic hosts human coronavirus lowest mechanism Mutation mutations natural selection Non-synonymous nucleotide substitution other coronavirus outbreak pattern performed Positive selection proportion RaTG13 Result SARS-CoV-2 selective Specific spike gene synonymous synonymous mutation synonymous substitution the spike protein unlikely viral pathogenicity Wuhan, China [DOI] 10.3389/fmicb.2020.584717 PMC 바로가기 [Article Type] Microbiology
Phylogenomics Analysis of SARS-CoV2 Genomes Reveals Distinct Selection Pressure on Different Viral StrainsResearch Article Published on 2020-11-272022-10-27 Journal: BioMed Research International [Category] Coronavirus, MERS, SARS, [키워드] Analysis carried codon correlated evaluated genetic diversity Genome genomic Genomic analysis globe indicate mutational bia mutational rate natural selection nine Novel coronavirus nucleotide substitution outbreak Phylogenomics Positive selection pressure SARS-CoV2 SARS-CoV2 genome SARS-CoV2 genomes Selection selection pressure Site strain translational viral genomes viral strain [DOI] 10.1155/2020/5746461 PMC 바로가기 [Article Type] Research Article
Genetic Spectrum and Distinct Evolution Patterns of SARS-CoV-2Microbiology Published on 2020-09-252022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Clustering Co-infection Complete coronavirus country COVID-19 Evolution exhibited Genetic genetic variants Genome Genome sequences group homogenous Host Mutation nucleotide substitution occurred Patient pattern RaTG13 Recombination representing SARS-CoV-2 SARS-CoV-2 genome sequence single-nucleotide SNV SNVs Spectrum Tolerance variant viral strain viral strains Wuhan-Hu-1 [DOI] 10.3389/fmicb.2020.593548 PMC 바로가기 [Article Type] Microbiology