Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascadeShort communication Published on 2022-04-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] 신약개발, [키워드] acute lung injury ameliorated attenuate cascade cytoplasmic drug escitalopram HDAC4 IC50 infiltration Inflammatory responses inhibited inhibiting investigated Lung injury mice morbidity and mortality neutrophil NF-κB signaling nucleus p65 pathway pro-inflammatory cytokine promoted pulmonary injury reduced SIK2 translocated Treatment triggered [DOI] 10.1016/j.bbrc.2022.02.015 [Article Type] Short communication
Could the COVID-19-Driven Increased Use of Ivermectin Lead to Incidents of Imbalanced Gut Microbiota and Dysbiosis?COVID-19로 인해 증가된 Ivermectin 사용이 장내 미생물 불균형 및 Dysbiosis를 유발할 수 있습니까?Review Published on 2022-04-012022-09-11 Journal: Probiotics and antimicrobial proteins [Category] COVID19(2023년), SARS, 치료제, [키워드] Affect animals COVID-19 diagnosed with COVID-19 drug Dysbiosis eukaryotic gut microbiota hosts humans incident Increased individual Infection Ivermectin nucleus SARS-CoV-2 SARS-COV-2 infection suggestion susceptible Treatment virus [DOI] 10.1007/s12602-022-09925-5 PMC 바로가기 [Article Type] Review
Cold atmospheric plasma for preventing infection of viruses that use ACE2 for entry진입에 ACE2를 사용하는 바이러스의 감염을 예방하기 위한 저온 대기 플라즈마Article Published on 2022-03-142022-09-12 Journal: Theranostics [Category] MERS, SARS, 진단, [키워드] ACE2 activated angiotensin-converting enzyme 2 approach atmospheric Cell cells Cold cold atmospheric plasma (CAP). component COVID-19 Direct domains Effect effective Efficacy enzyme Epidemic epithelial examined expression feasible helping Host hydroxyl impair in vitro in vivo inhibit Interaction mammary medium nuclear translocation nucleus PAM plasma Plasma activated medium (PAM) preventing infection pseudovirus SARS-CoV-2 SARS-CoV-2 virus Spike protein Support translocation triggered triggering Vaccine virus virus entry virus receptor [DOI] 10.7150/thno.70098 PMC 바로가기 [Article Type] Article
Breastfeeding experiences during the COVID-19 pandemic in Spain:a qualitative studyResearch Published on 2022-02-222022-10-30 Journal: International Breastfeeding Journal [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] addition adopted affected analysed Breastfeeding breastfeeding support Care caused changes in community health services conducted Contagion coronavirus COVID-19 COVID-19 pandemic emotional group groups Health Hospitalization increase in Infection information inherent lockdown loneliness measure Newborn nucleus pandemic participant positive Primary Health Care professional provided public health recruited reproductive Result SARS-CoV-2 supplementary material Support thematic analysis transcribed women [DOI] 10.1186/s13006-022-00453-0 PMC 바로가기 [Article Type] Research
Atypical lymphoid cells circulating in blood in COVID-19 infection: morphology, immunophenotype and prognosis valueCOVID-19 감염에서 혈액에서 순환하는 비정형 림프 세포: 형태, 면역 표현형 및 예후 값Article Published on 2022-02-012022-09-11 Journal: Journal of Clinical Pathology [Category] 바이오마커, 치료기술, [키워드] Accuracy activated analysed Analysis approach Atypical lymphocyte automatically Blood blood sample Blood samples blue CD4 CD8 T cells Characteristics circulating classical clinical CNNs Convolutional neural network Convolutional neural networks COVID-19 COVID-19 patient COVID-19 patients Cytometry cytoplasm D-dimer develop Digital image effector memory ENhance Evolution filtration rate glomerular filtration rate Haemoglobin Immunophenotyping Laboratory lymphocyte Lymphocyte count lymphocyte counts Lymphocytes lymphoid cell Morphological morphological and microscopic findings morphology Neutrophils nucleus outcome Patient patients died patients without COVID-19 procalcitonin Prognosis Protein reactive reported sensitivity specificity T cells these cell These cells total protein virus-specific T cell viruses was performed were used [DOI] 10.1136/jclinpath-2020-207087 PMC 바로가기 [Article Type] Article
A New Method for the Sputum Cytology Test Without Direct Contact to Specimens During COVID-19 PandemicMedicine Published on 2022-01-282022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] addition alcohol analyzed Antigen Blood body fluid Cell cell antigen cell antigens cell membrane collected Complete Contact control group Coronavirus disease 2019 COVID-19 COVID-19 outbreak COVID-19 pandemic cytology cytoplasm direct contact excreta exhibited experimental group expressed expression hospital increased the risk Infection leukocyte lung cancer medical alcohol morphology New nucleus pandemic pathology Patient processed PROTECT protection provided Result Sample sealed sealed bag specimen Spread sputum sputum cytology Sputum sample staining Test Thyroid Transcription TTF1 tumor cell two group two groups virus was determined [DOI] 10.3389/fmed.2021.746731 PMC 바로가기 [Article Type] Medicine
Inflammasome activation in neutrophils of patients with severe COVID-19Research article Published on 2022-01-062022-10-05 Journal: Blood advances [Category] COVID19(2023년), SARS, 변종, [키워드] Activation acute respiratory syndrome ASC coronavirus correlation COVID-19 COVID-19 patient demonstrated engage fluorescent form human disease implicated induce Inflammasome inflammasome activation Inflammation leukocytes Macrophage mice Microscopy microtubule organizing center monocyte NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils NLRP3 inflammasome nuclear nuclei nucleus pathogenesis of COVID-19 Patient Peripheral blood positive Protein reporter Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient stimulated the cytokine storm tracheal aspirate [DOI] 10.1182/bloodadvances.2021005949 [Article Type] Research article
Cardiovascular Risk After SARS-CoV-2 Infection Is Mediated by IL18/IL18R1/HIF-1 Signaling Pathway AxisSARS-CoV-2 감염 후 심혈관 위험은 IL18/IL18R1/HIF-1 신호 경로 축에 의해 매개됩니다Immunology Published on 2022-01-052022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] activate activated Activation Algorithm Analysis Aneurysm aneurysms Atherosclerosis axis cardiovascular cardiovascular risk Cell cell types changes in characterized choice Compound COVID-19 COVID-19 infection detect Epigenetic expected functional gene co-expression network HIF-1 HIF-1 signaling pathway HIF1a hypoxia identify IL-18 IL18 IL18R1 Infection Inference Intercellular communication interleukin locus Macrophage macrophages MAP2K1 mechanism Mediated MEK inhibitor Methylation NF-κB nucleus objective pathway Pathways PBMC phenotype phenotypic Potential promote promoted Proteins Proteomic analysis Regulation Regulatory Regulon Result SARS-CoV-2 SARS-COV-2 infection scRNA-seq Signaling signaling pathway smooth muscle therapeutic compound therapeutic target Treatment type I interferon type I interferon pathway vascular smooth muscle vascular smooth muscle cells VIPER was used WGCNA with COVID-19 [DOI] 10.3389/fimmu.2021.780804 PMC 바로가기 [Article Type] Immunology
USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AIDArticle Published on 2022-01-042022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, [키워드] acute respiratory syndrome adjuvants Affect antibody B cell B cell response BCR coronavirus Cytidine deaminase deficiency demonstrated deubiquitinase domain expression Extracellular function Genes HIV-1 Human immunodeficiency virus immunization immunology initiate mechanisms Molecular biology neutralizing antibody NLS nuclear nucleus Phosphorylation promoted Protein protein levels Recombination reducing regulate SARS-CoV-2 significantly TLR USP10 Vaccine Vaccines [DOI] 10.1038/s41392-021-00858-z PMC 바로가기 [Article Type] Article
Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID제2형 당뇨병, 후기 발병 알츠하이머병 및 장기 코로나에서 엽산 매개 단일 탄소 대사 장애Review Published on 2021-12-232022-09-10 Journal: Medicina [Category] SARS, 유전자 메커니즘, [키워드] Abnormalities Alzheimer’s disease Alzheimer’s disease biochemical Biomarker biosynthetic biosynthetic pathways carbon clinical disease COVID COVID-19 cytoplasm developmental diabetes Diabetes Mellitus Diseases elevated epigenetics folate functional homocysteine hyperhomocysteinemia Impaired incorporation knowledge Long Long COVID mechanism metabolic network metabolic pathway metabolic pathways metabolism Mitochondria MTHFR gene mutations nucleus nutritional B vitamin deficiencies PASC pathology pathway progression Repurposed drugs responsible SARS-CoV-2 Stress the reader Therapeutics Treatment Type type 2 diabete Type 2 diabetes mellitus Vitamin vitamins [DOI] 10.3390/medicina58010016 PMC 바로가기 [Article Type] Review