Gene-by-gene screen of the unknown proteins encoded on Plasmodium falciparum chromosome 3Article Published on 2023-01-182024-08-27 Journal: Cell Syst [Category] 말라리아, [키워드] BioID evolution of genes kinetochore knock sideways malaria mitosis nucleus orphan genes Plasmodium falciparum protein function proteomics SKA taxon-specific proteins.
Effects of Human Nucleolus Upon Guest Viral-Life, Focusing in COVID-19 Infection: A Mini- ReviewReview Article Published on 2022-12-152022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] accumulating biogenesis Cell cell stress concerning coronavirus disease Coronavirus infections COVID-19 DDR disrupt DNA damage Effect endotheliopathy eukaryotic cells Evidence Focusing function gene silencing Human human diseases MINI nucleoli Nucleolopathy Nucleolus nucleus organism Organisms pathogenic precursor Protein provided Regulation Replication review subcellular tRNA viral infection viral infections virus [DOI] 10.30699/IJP.2021.540305.2744 PMC 바로가기 [Article Type] Review Article
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity Research Published on 2022-07-252022-10-05 Journal: Nature Immunology [Category] 변종, [키워드] Activation affecting agonist antagonized antiviral immunity Critical deficiency demonstrated deteriorate DNA domain driver expression genetic code identify IFN IFN signaling IFN-I information inhibited Innate innate antiviral immunity Innate immunity interferon IRF3 IRF7 mechanism mice Mortality nucleus occur regulate rescued restored resulting SIRT1 Type I IFN Viral load viral replication [DOI] 10.1038/s41590-022-01269-0 [Article Type] Research
SARS-CoV-2 and the NucleusSARS-CoV-2와 핵Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] blocked caused cells cilia Clinical studies contribute COVID-19 pandemic Critical cytoplasm DNA DNA damage Epigenetic epigenetics Genome greatly reduce immune responses inhibitor innate immune responses Innate immunity lack life cycle mechanisms metabolism mRNA metabolism nuclear nuclear translocation nuclear transport. nucleus other coronavirus other coronaviruses pathway Pathways pharmacological Regulation replicated RNA virus rupture SARS-CoV-2 small molecule small molecule drug small molecule drugs Therapeutic treatment Transport virus infection virus replication [DOI] 10.7150/ijbs.72482 PMC 바로가기 [Article Type] Review
RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIaRANBP2 및 USP9x는 아데노바이러스 마이너 코트 단백질 IIIa의 핵 수입을 조절합니다Article Published on 2022-06-162022-09-11 Journal: PLoS Pathogens [Category] 유전자 메커니즘, [키워드] accumulation acute respiratory illness acute respiratory illnesses Adenovirus Affinity purification Amino acid amino acids Analysis antiviral therapeutics antiviral therapy bind binding blockade C-terminus Cell cell nuclei cells cellular competition conjunctivitis counteract COVID-19 demonstrated deregulated disparate expression Host implication indicated infected cells Infection interact Interaction interactions mass spectrometry maturation mechanism Microscopy nuclear nuclei nucleus outbreak parasites protease Protein Proteins Ranbp2 reduced regulate respiratory pathogen retention subsequent surface plasmon surface plasmon resonance transmission electron microscopy Transport USP9x Vaccine viral genome replication Viral particles Viral protein virion virion assembly virus virus-infected cell virus-infected cells wild type [DOI] 10.1371/journal.ppat.1010588 PMC 바로가기 [Article Type] Article
Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 SecretionIFN-β 및 IL-6 분비를 효율적으로 억제하기 위해 SARS-CoV-2 ORF6 단백질에 의해 핵공 이동이 방해됨Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation addition antagonistic antiviral response block cascade characterized clinical outcomes contributing to counteract Critical cytokine Cytokines cytoplasm cytoplasmic demonstrated ENCODE exacerbated Factors feature Genes Host host immune system IFN-β IL-6 immune immune evasion Infection Inflammation interferon interferon antagonist interleukin interleukin-6 MAVS MDA-5 mechanism Messenger RNA movement mRNA multifunctional NF-κB not affected novel SARS-CoV-2 virus nuclear translocation nucleus occurred ORF6 pro-inflammatory cytokine pro-inflammatory cytokines Protein reported RIG-I SARS-CoV-2 SARS-CoV-2 ORF6 protein SARS-CoV-2 virus Signaling STAT suppresse suppression the SARS-CoV-2 Traffic transcription factor transcription factors transcriptional viral infection viral pathogenesis virulence virus [DOI] 10.3390/v14061273 PMC 바로가기 [Article Type] Article
Characterization of the Interaction Between SARS-CoV-2 Membrane Protein (M) and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target잠재적 치료 표적으로서 SARS-COV-2 막 단백질 (M)과 증식 세포 핵 항원 (PCNA) 사이의 상호 작용의 특성화Article Published on 2022-05-232022-08-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] addition association Cell characterization Coronaviridae family COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 therapy cytoplasm DNA DNA damage DNA replication expression function immunofluorescence immunohistochemistry immunoprecipitation in vitro increase in infected with SARS-CoV-2 Interaction ligation Localization lung M protein marker membrane protein nucleus PCNA Potential reduction repair reported responsible SARS-CoV-2 target the Coronaviridae therapy transfected with translocation Transport Verdinexor viral-host interaction virion virus [DOI] 10.3389/fcimb.2022.849017 PMC 바로가기 [Article Type] Article
Pyridine Compounds with Antimicrobial and Antiviral Activities항균 및 항바이러스 활성을 갖는 피리딘 화합물Review Published on 2022-05-182022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activity analgesic Anti-inflammatory anticonvulsant antidiabetic antimicrobial antioxidant Antiviral antiviral activities binding caused Compound compounds correlation COVID-19 pandemic determine group groups heterocyclic compounds hydrocarbon IMPROVE Interaction life-threatening linker molecular docking studies molecules nucleus priority Protein pyridine Research SARS-CoV-2 virus singular specific protein synthesis the SARS-CoV-2 virus therapeutic water [DOI] 10.3390/ijms23105659 PMC 바로가기 [Article Type] Review
Pharmacophore based virtual screening for natural product database revealed possible inhibitors for SARS-COV-2 main protease천연물 데이터베이스에 대한 약전 기반 가상 스크리닝을 통해 SARS-COV-2 주요 프로테아제에 대한 가능한 억제제가 밝혀졌습니다.Article Published on 2022-05-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 치료제, [키워드] absence antiviral drug approved candidate Candidates Compound compounds COVID-19 COVID-19 pandemic COVID-19 virus database diterpene drug effort eight Ent-kaurane enzyme Health Infection inhibitor inhibitors main protease inhibitors molecular docking MPro Nature nucleus overcome pharmacophore positive problems protease protease inhibitors proteinase provide reported SARS-CoV-2 SARS-CoV-2 main protease suggested terpenoids triggered Virtual screening virus infection [DOI] 10.1016/j.virol.2022.03.003 PMC 바로가기 [Article Type] Article
The INDEPTH (Impact of Nuclear Domains on Gene Expression and Plant Traits) Academy: a community resource for plant scienceINDEPTH(유전자 발현 및 식물 특성에 대한 핵 도메인의 영향) 아카데미: 식물 과학을 위한 커뮤니티 리소스Article Published on 2022-04-052022-09-11 Journal: Journal of experimental botany [Category] 유전자 메커니즘, [키워드] Academy Action Analysis automated Community community resource Control COST Action COVID-19 pandemic deep learning driven by engage Epigenetic epigenetics Gene Expression growth image repository Impact Laboratory nuclear nucleus Open Access plant plants produced protocols provide recent Repository researcher resource resources Standardization standardized protocols Support tutorials webinars. [DOI] 10.1093/jxb/erac005 PMC 바로가기 [Article Type] Article