A Rapid and Sensitive Microfluidics-Based Tool for Seroprevalence Immunity Assessment of COVID-19 and Vaccination-Induced Humoral Antibody Response at the Point of Care현장 진료에서 COVID-19 및 예방 접종 유도 체액 항체 반응의 혈청유병 면역 평가를 위한 신속하고 민감한 미세유체 기반 도구Article Published on 2022-08-102022-09-11 Journal: Biosensors [Category] SARS, 변종, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody approved assessment booster causative agent circulating clinical decision clinical decision support tool clinician conditions convalescent plasma COVID-19 cross-reactive antibody death diagnostic diagnostics disease severity donors ecosystem Health help Hospitalization humoral Humoral immunity immunization immunized immunocompromised individual individuals induce infected individual Infection Microfluidics multiple dose multiple doses optimization Patient platform POC POC test Point point of care point-of-care predict proof proof of concept protein-based vaccine Protein-based vaccines Quantitative Rapid reducing researcher response risk robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2-specific IgG sensitive Seroconversion Serological assay Seroprevalence seroprevalence. Support the disease the timing vaccination Viral viral variant while [DOI] 10.3390/bios12080621 PMC 바로가기 [Article Type] Article
Association between COVID-19 and Sick Leave for Healthcare Workers in a Large Academic Hospital in Southern Italy: An Observational StudyCOVID-19와 남부 이탈리아의 대규모 학술 병원 의료 종사자의 병가 사이의 연관성: 관찰 연구Observational Study Published on 2022-08-052022-09-11 Journal: International Journal of Environmental Research an [Category] SARS, 변종, 임상, [키워드] CAT score changed conducted Coverage COVID-19 decrease evaluate HCWs healthcare healthcare worker Healthcare workers increase in involved Italy management observational study omicron Omicron variant optimization pandemic Perception public health questionnaire Regulation SARS-CoV-2 shown sick sick leave significant difference significant differences South subject Symptom Symptoms Symptoms. university hospital vaccination variant worker [DOI] 10.3390/ijerph19159670 PMC 바로가기 [Article Type] Observational Study
Optimization and performance evaluation of double-stranded probe in real-time PCRArticle Published on 2022-08-012023-07-09 Journal: Analytical biochemistry [Category] COVID19(2023년), [키워드] Double-stranded probes HBV optimization Real-time PCR SARS-CoV-2. [DOI] 10.1016/j.ab.2022.114711 PMC 바로가기
Expecting individuals’ body reaction to Covid-19 based on statistical Naïve Bayes techniqueResearch article Published on 2022-08-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 변종, [키워드] Accuracy affected average binary classification Classifier collected competing complications compose COVID-19 dataset diagnosing drastic Efficiency expectation feature Fisher Gray hybrid Improved include Infection introduced mutated virus Naïve Bayes occur optimization outlier outperform phase Precaution Precision predict prediction provide Prudential Expectation reached recall rejection routine blood test score selected Selection statistical Strategy subset training data virus Wolf Wrapper [DOI] 10.1016/j.patcog.2022.108693 [Article Type] Research article
Optimization and evaluation of a live virus SARS-CoV-2 neutralization assay살아있는 바이러스 SARS-CoV-2 중화 분석의 최적화 및 평가Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added antibody application calculated cell monolayer cell suspension cells clinical isolates Coefficient of variance coronavirus correlated correlation Critical described dose ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated functional antibody response functional antibody responses growth immune evasion Immunity include Incubation period infecting Influenza Influenza virus inoculation isolates Live virus microneutralization neutralization Neutralization assay neutralization titers nucleocapsid protein optimization parameter Post-infection Precision protein level reduced replicating virus respiratory SARS-CoV-2 SARS-CoV-2 clinical isolate SARS-CoV-2 clinical isolates SARS-CoV-2 microneutralization assay SARS-CoV-2 neutralization severe acute respiratory syndrome Coronavirus the SARS-CoV-2 the strongest therapeutic Vaccine variance Vero E6 Vero E6 cell VERO E6 cells Viral Viral variants virus virus infection virus inhibition virus inoculum virus neutralization assays Virus titration was determined WHO [DOI] 10.1371/journal.pone.0272298 PMC 바로가기 [Article Type] Article
DNA aptamers inhibit SARS-CoV-2 spike-protein binding to hACE2 by an RBD- independent or dependent approachDNA 앱타머는 RBD-독립적 또는 의존적 접근에 의해 hACE2에 대한 SARS-CoV-2 스파이크-단백질 결합을 억제합니다Article Published on 2022-07-182022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] affinity anti-RBD anti-S2 Anti-spike approach aptamer best binding binding affinities binding affinity block can be used Candidates cells conserved coronavirus coronavirus COVID-19 pandemic Delta develop diagnostic DNA DNA aptamer Efficacy ELISA fusion aptamer hACE2 IMPROVE independent Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction Ligand ligands linker molecular New coronavirus omicron optimization outbreak Prevent RBD recognize reported S2-protein SARS-CoV-2 selection process sequence spike-protein spike-protein. the RBD therapeutic variant variants were measured WT spike [DOI] 10.7150/thno.74428 PMC 바로가기 [Article Type] Article
Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2고전적 지문과 비교하여 양자에서 영감을 받은 방법을 기반으로 한 약물 용도 변경은 SARS-CoV-2에 대한 잠재적인 항바이러스제를 밝혀냅니다.Article Published on 2022-07-182022-09-11 Journal: PLoS Computational Biology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] accelerated Algorithm Alpha Antiviral antiviral therapeutics approach approved B.1.1.7 B.1.351 B.1.617.2 Beta binary BMS-986094 Cell culture classical cobalamin Combination comparison Comparisons complex complexity Compound compounds computational resource computational resources COVID-19 pandemic cytotoxicity Delta demonstrated Drug repurposing DrugBank database Efficacy England evaluate form GS-6620 IC50 identify in vitro inhibit inhibited inhibitors inhibitory concentration limit maximum optimization overlap pace parameter predicted problem RdRP Remdesivir replication of SARS-CoV-2 resolved RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection screening method several variant several variants strain these compound these compounds vitamin B12 while [DOI] 10.1371/journal.pcbi.1010330 PMC 바로가기 [Article Type] Article
Community Wastewater-Based Surveillance Can Be a Cost-Effective Approach to Track COVID-19 Outbreak in Low-Resource Settings: Feasibility Assessment for Ethiopia Context커뮤니티 폐수 기반 감시는 자원이 부족한 환경에서 COVID-19 발병을 추적하기 위한 비용 효율적인 접근 방식이 될 수 있습니다: 에티오피아 상황에 대한 타당성 평가Article Published on 2022-07-122022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] approach assessment Can collected conditions conducted Context COVID-19 COVID-19 case COVID-19 outbreak distribution epidemiological Epidemiology Evidence feasibility feasible highest MBR MONITOR Nasopharyngeal swab nasopharyngeal swabs National nine optimization PCR testing plants positive processed protocol reported RIDA RT-PCR RT-PCR testing Sample SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 surveillance SPHMMC Surveillance tested track utility wastewater Wastewater-based epidemiology. [DOI] 10.3390/ijerph19148515 PMC 바로가기 [Article Type] Article
Artificial Intelligence-Based Data-Driven Strategy to Accelerate Research, Development, and Clinical Trials of COVID VaccineCOVID 백신의 연구, 개발 및 임상 시험을 가속화하기 위한 인공 지능 기반 데이터 기반 전략Review Published on 2022-07-062022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens Antiviral artificial artificial intelligence caused clinical Clinical practice clinical trial clinical trials computational approach Computational approaches coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 datasets detect development diagnostic drug effective healthcare facility Human coronavirus identify inhibitory introduced Lower medical system Model optimization pandemic problem Research SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Strategy therapy unique vaccination Vaccinations Vaccine vaccine candidates Vaccine development virus [DOI] 10.1155/2022/7205241 PMC 바로가기 [Article Type] Review
From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease용도 변경에서 재설계까지: SARS-CoV-2 주요 프로테아제의 강력한 억제제에 대한 보세프레비르의 최적화Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3C-like protease activities activity addition alpha-ketoamides alphacoronavirus approach Betacoronavirus boceprevir complexes Complexes coronavirus COVID-19 coxsackievirus Coxsackievirus B3 crystal structure crystal structures Crystallography enterovirus enterovirus 3C protease exhibited Glutamine HCoV HCoV-NL63 hepatitis C hepatitis C virus inhibitor lactam M pro main protease moderate NL63 optimization potency potent protease Protease inhibitor Proteases replacing repurposing resulting SARS-CoV-2 starting structure-based design Structure-based drug design telaprevir telaprevir. the SARS-CoV-2 treatments for COVID-19 Validity virus X-ray X-ray crystallography [DOI] 10.3390/molecules27134292 PMC 바로가기 [Article Type] Article