SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogrammingArticle Published on 2023-01-052023-07-11 Journal: Cell [Category] COVID19(2023년), [키워드] airway epithelial cells cilia COVID-19 microvilli organoids protein kinases proteomics respiratory synctital virus respiratory virus SARS-CoV-2 [DOI] 10.1016/j.cell.2022.11.030 PMC 바로가기
SARS-CoV2 entry factors are expressed in primary human glioblastoma and recapitulated in cerebral organoid modelsResearch Published on 2023-01-032024-09-05 Journal: Journal of neuro-oncology [Category] update2024, [키워드] Brain Glioblastoma Human IPSC organoids SARS-CoV2 stem cells [DOI] 10.1007/s11060-022-04205-2 PMC 바로가기 [Article Type] Research
3D Organoid Assay of the Impact of Infected Erythrocyte Adhesion on the Blood-Brain Barrierarticle Published on 2022-12-312024-09-01 Journal: Methods in molecular biology (Clifton, N.J.) [Category] 말라리아, [키워드] Adhesion assay binding inhibition Blood–brain barrier cerebral malaria Human model Neurovascular unit organoids PfEMP1 [Article Type] article
Salmonella enterica Infection of Human and Mouse Colon Organoid-Derived Monolayersarticle Published on 2022-12-312024-09-01 Journal: Methods in molecular biology (Clifton, N.J.) [Category] 살모넬라증, [키워드] Cell culture Colonoids Host–pathogen interaction in vitro model Infection intestinal epithelial cells organoids Salmonella [Article Type] article
Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cellsArticle Published on 2022-12-162023-07-11 Journal: STAR protocols [Category] COVID19(2023년), [키워드] Cell culture cell differentiation Microbiology Microscopy organoids stem cells [DOI] 10.1016/j.xpro.2022.101872 PMC 바로가기
Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculatureArticle Published on 2022-12-092023-07-09 Journal: Cardiovascular Research [Category] COVID19(2023년), [키워드] COVID-19 endothelial permeability organoids SARS-CoV-2 thrombosis Vasculopathy [DOI] 10.1093/cvr/cvac097 PMC 바로가기
Choosing a cellular model to study SARS-CoV-2Article Published on 2022-10-212022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Antiviral compound approach Cell cell line cell lines cell model cellular China consequence Coronavirus infection COVID-19 Disadvantages experimental model growth Healthcare systems help in vitro in vitro approaches Infection Infectious disease Laboratory organoids pathogen Pathogenesis reducing Replication required Research researcher resources SARS-CoV-2 susceptible susceptible cells viral culture viral pathogenicity virus viruses [DOI] 10.3389/fcimb.2022.1003608 PMC 바로가기
SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicitySARS-CoV-2 스파이크 N-말단 도메인은 TMPRSS2 의존성 바이러스 진입 및 융합원성을 조절합니다Article Published on 2022-08-162022-09-11 Journal: Cell Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway B.1.617 cell-cell fusion characterized chimeric spike chimeric spikes coronavirus CP: Microbiology Delta enrichment Entry exhibit function Fusogenicity increase Infection Interaction lentivirus Lineage lung cell lung cells Microbiology modulate Mutation N-terminal domain NTD NTDs omicron Organoid organoids pseudotyped Region S1/S2 cleavage S1/S2 cleavage efficiency SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus spike TMPRSS2 transfer variants variants of concern viral entry virus entry VOCs wild-type [DOI] 10.1016/j.celrep.2022.111220 PMC 바로가기 [Article Type] Article
SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster modelSARS-CoV-2 VOC 유형 및 생물학적 성별은 중증 COVID-19 드워프 햄스터 모델에서 몰누피라비르 효능에 영향을 미칩니다Article Published on 2022-07-292022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, 치료법, 치료제, [키워드] Affect Antiviral benefit Cell disease effect size Efficacy evaluate females ferret ferrets hamster highest Human airway epithelium IMPROVE in vivo Infection inhibited lung Lung injury magnitude males management molnupiravir omicron oral organoids pathogenicity potency prevented reduced reduction in SARS-CoV-2 SARS-CoV-2 variants severe COVID-19 Sex survived Transmission Treatment effect size Trial triggered variants of concern virus load VoC [DOI] 10.1038/s41467-022-32045-1 PMC 바로가기 [Article Type] Article
Infecting kidney organoids with a cDNA reporter clone of SARS-CoV-2Article Published on 2022-07-212023-07-10 Journal: STAR protocols [Category] COVID19(2023년), [키워드] Cell-based Assays organoids stem cells [DOI] 10.1016/j.xpro.2022.101617 PMC 바로가기