other coronaviruses – Page 2 – Communicable Diseases Research

Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies

마비 관련 키나아제는 SARS-CoV-2 감염에 필요하며 항바이러스 전략의 세포 표적입니다

Article

Published on 2022-08-012022-09-11
Journal: Antiviral Research
[Category] COVID19(2023년), SARS, 치료제,

Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signatures

COVID-19의 자가항체는 항바이러스 체액 반응 및 뚜렷한 면역 신호와 상관관계가 있습니다

Article

Published on 2022-08-012022-09-11
Journal: Allergy
[Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, 치료제,

[키워드] acute COVID-19 acute disease acute SARS-CoV-2 infection alteration antibody Antibody titer Antibody titers antineutrophil cytoplasmic antibodies antinuclear antibodies Antiviral association autoantibodies autoantibodies. autoantibody Autoimmune autoimmune pathology B-cell breadth clinically Cohort Comorbidities comparable controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cross-reactive cytoplasmic demonstrated detect disease disease course exhibited feature healthy controls humoral immune response Humoral response humoral responses immune immune responses immune signature Immunity immunofluorescence assay implication indirect immunofluorescence individual Infection Inflammatory occur other coronavirus other coronaviruses Paired analysis Patient patients performed Prevalence proteomics SARS-CoV-2 screened serological serum severe COVID-19 severity of COVID-19 subgroup of patient trajectory vaccinated individuals VirScan
[DOI] 10.1111/all.15302 PMC 바로가기 [Article Type] Article

Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variants

SARS-CoV-2 및 그 변이체에 T 세포 교차 보호를 부여하는 바이러스 면역원성 발자국

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 변종,

[키워드] 229E 3D structure 3D Structures approach Asymptomatic case Asymptomatic cases CD8+ T cell cellular cellular response concern conserved contributing to Coronaviruses COVID-19 cross-protection cross-reactivity death disease Endemic epitope Epitopes examination expected explain explanation Features Genetic Heterologous HLA-A HLA-A*02:01 human coronaviruses human coronaviruses 229E human infection Immunity immuno informatics immunogenic immunogenic feature immunogenicity include indicate individual individuals infected individuals Infection involved molecular OC43 other coronaviruses outcomes pathogen Pathogens peptide peptides physicochemical Population SARS-CoV SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 sequence sequence Sequence analysis severe disease Structural analysis structural analysis. Structure T cell T-cell T-cell epitopes target Trigger uninfected Vaccine development variant variants virus viruses Wuhan
[DOI] 10.3389/fimmu.2022.931372 PMC 바로가기 [Article Type] Article

The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses

이중막 소포(DMV): SARS-CoV-2 및 기타 포지티브 센스 단일 가닥 RNA 바이러스 복제 전용 바이러스 유도 소기관

Review

Published on 2022-07-162022-09-11
Journal: Cellular and Molecular Life Sciences
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analogy Antiviral approach autophagic biogenesis can not Cell organelle coronavirus COVID-19 Double-membrane vesicle Endoplasmic reticulum export Genome Golgi apparatus HCV hepatitis C hepatitis C virus host cell host cell membrane host cell membranes induce initial Innate immunity interactions involved lipid droplet lipid droplets lipids mechanism mechanisms membrane metabolite metabolites Mitochondria morphology non-structural protein organelle other coronavirus other coronaviruses pathogen phylogenetically positive-sense single-stranded RNA Positive-sense single-stranded RNA virus Replication replication of SARS-CoV-2 Replication organelle required RNA RNA virus SARS-CoV-2 sealed shown similarity single-stranded storage supply these viruses Vesicle viral replication Viral RNA virions virus Virus/cell interactions. viruses
[DOI] 10.1007/s00018-022-04469-x PMC 바로가기 [Article Type] Review

Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

1년 동안 SARS-CoV-2-특이적 T 세포 사이토카인 생성 반응에 대한 종단 평가는 질병 중증도와 관련된 더 큰 면역과 함께 다중 사이토카인 증식 반응의 지속성을 보여줍니다

Article

Published on 2022-07-132022-09-11
Journal: Journal of Virology
[Category] COVID19(2023년), SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all subjects assessment average CD4 CD8 Cell Cell-mediated immunity clone coronavirus Coronaviruses Critical cytokine cytokine response Cytokines declined demonstrated dominant ELISPOT ELISpot assay envelope enzyme-linked immunosorbent epitope Epitopes Ex vivo female Frequency gamma interferon granzyme B greater GzmB highlight IFN-γ IL-2 immune immune modeling. Immunity immunodominant immunodominant epitope immunodominant epitopes induce Infection interferon interleukin interleukin 2 kill longitudinal male median membrane nucleocapsid observation other coronaviruses peaked persistence post-symptom onset potent predicted produced producing proliferative PSO reduced regions response robust SARS-CoV-1 SARS-CoV-2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus severe disease structural protein structural proteins subject survivor T cell T cell immunity T cell memory T cell response T cell responses T cells target cells Vaccine viral infections Year
[DOI] 10.1128/jvi.00509-22 PMC 바로가기 [Article Type] Article

SARS-CoV-2 and the Nucleus

SARS-CoV-2와 핵

Review

Published on 2022-07-112022-09-11
Journal: International Journal of Biological Sciences
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteins

COVID-19 백신 접종은 고유의 코로나바이러스 스파이크 단백질로 보존된 에피토프에 대한 진화하는 교차 반응성 항체 반응을 이끌어냅니다

Article

Published on 2022-07-052022-09-11
Journal: Cell Reports
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] Alanine antibody conserved coronavirus coronavirus spike protein CoV COVID-19 pandemic COVID-19 vaccination CoVs CP: Immunology CP: Microbiology cross-reactive cross-reactive antibody detectable elicit Endemic epitope Epitopes experiments homolog identify Immunity immunology longitudinal samples mechanism Microbiology mRNA mRNA-1273 mRNA-1273 vaccine multiplexed serology observé other coronavirus other coronaviruses phylogenetically reactivity regions residue SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology spike subject the vaccine trajectory triggered vaccination vaccination. vaccine response vaccine-induced antibody response widespread
[DOI] 10.1016/j.celrep.2022.111022 PMC 바로가기 [Article Type] Article

Role of IgM Memory B Cells and Spleen Function in COVID-19

COVID-19에서 IgM 기억 B 세포와 비장 기능의 역할

Review

Published on 2022-06-302022-09-12
Journal: Frontiers in Immunology
[Category] MERS, 진단, 치료기술,

Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages

COVID-19 환자의 비인두 샘플에서 SARS-CoV-2 분석은 다른 계통과 관련하여 우려되는 변이체의 성장 특성을 배치하여 인구 변이 및 다양한 표현형을 보여줍니다

Article

Published on 2022-06-292022-09-11
Journal: mSphere
[Category] COVID19(2023년), SARS, 변종,

[키워드] A549 cells Alpha amplified Beta Beta variant Biology biology of SARS-CoV-2 causative agent Cell Cell culture cell line cells change characterized clinical isolates clinical samples concern Context coronavirus COVID-19 Delta disease effective Evolution genetic diversity genetics genome sequence genomic global pandemic growth growth kinetics hACE2 hospitalized patient hospitalized patients humans immune evasion increased risk indicated Infection isolate isolates less Lineage minor minor genomic variants morbidity Mortality Nasopharyngeal swab nasopharyngeal swabs New no difference not different omicron Other other coronaviruses other variant other variants pandemic patients pattern planet Population Population dynamics Population genetics Postinfection preserved property Research RNA RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence several variants Spread suggested Transmission vaccination Vaccine Variability variant variants variants of concern variants of SARS-CoV-2 variants. Variation Vero E6 Vero E6 cell VERO E6 cells virus Virus evolution VoC VOCs widespread with COVID-19
[DOI] 10.1128/msphere.00913-21 PMC 바로가기 [Article Type] Article

The role of natural products from medicinal plants against COVID-19: traditional medicine practice in Tanzania

Research article

Published on 2022-06-152022-10-05
Journal: Heliyon
[Category] 치료제,