Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway
Article
[키워드] abrogate
activated
addition
bind
binding
biological significance
cellular processe
complex
disrupt
DNA
Epigenetic
Evidence
expression
favor
Gene Expression
HDAC2
Host
host antiviral response
IFN response
IFN signaling pathway
IFN-stimulated genes
IFNβ
IL-1β
IL-6
immune response gene
inhibit
inhibition
inhibitory
interact
Interaction
interferons
involved
IRF3
nsp5
over
Pathogenesis
pathway
promote
promoter
promoters
protease
Protease activity
protein interaction
protein-protein interactions
reduce
Regulation
Replication
repress
required
RNA
SARS-CoV-2
SARS-CoV-2 protein
Signaling
signaling pathway
significantly
subset
Type
Type I IFN
Type I IFN signaling
type I interferon
viral infection
viral infections
Viral protein
virus
[DOI] 10.1128/spectrum.02322-22 PMC 바로가기
[DOI] 10.1128/spectrum.02322-22 PMC 바로가기