Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic DonorsArticle Published on 2020-08-072022-10-28 Journal: Biology [Category] COVID-19, [키워드] ACE2 ACE2 expression ADAM17 adipose age binding BMI cells correlated COVID-19 diabete diabetes Diabetic diabetics Donor donors Endocrine entry of SARS-CoV-2 explain Express expression expression data expression level expression pattern female Gender Human human islets islet islets Microarray not affected occur pancreatic pancreatic islet pancreatic islets patients priming profile promote receptor required Revealed RNA-Seq RNA-sequencing S1 protein SARS-CoV-2 severity of COVID-19 significantly higher significantly increased statistically Symptom T2D the S protein thought tissue TMPRSS2 TMPRSS2 expression Variation viral spike [DOI] 10.3390/biology9080215 PMC 바로가기 [Article Type] Article
How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes: a review세포 사멸 β 세포가 내성 또는 자가 면역 당뇨병에 대한 면역 반응을 지시하는 방법: 리뷰Original Paper Published on 2015-01-222022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] β-Cells Activation antigen presenting cell antigen presenting cells APCS Apoptosis apoptotic cell clearance apoptotic cells apoptotic β-cell autoantigen Autoantigens Autoimmune autoimmune attack autoimmune diabetes Autoimmune disease Autoimmune diseases Autoimmunity Cell contribute contributing to dendritic cells diabetes Effect Efferocytosis endogenous insulin secretion immune response immune tolerance immunological tolerance immunotherapies Immunotherapy increase in induce Inflammation insulin insulin-producing β-cell insulin-producing β-cells long-term tolerance maintenance maturation mechanism medical health challenge metabolic disease pancreatic islet pancreatic islets pancreatic islets of Langerhans Patient physiological mechanism Research self T1D target cell target cells therapy Tolerance tolerance to self translational Treatment Type 1 diabete Type 1 diabetes β-cell β-cells [DOI] 10.1007/s10495-015-1090-8 PMC 바로가기 [Article Type] Original Paper