Neuroimmune contributions to Alzheimer’s disease: a focus on human data Reviews Published on 2022-06-062022-10-05 Journal: Molecular Psychiatry [Category] 바이오마커, 신약개발, [키워드] Alzheimer’s disease Analysis Cell cellular Central nervous system CNS Comorbidity component composed Course effort epidemiological data Factor Genetic human immune function human participant immune immune response immune system limitation microenvironment modulate MONITOR multiphasic offer pathologic pathophysiology Perturbation required resources respond response robust Study design subtype variety [DOI] 10.1038/s41380-022-01637-0 [Article Type] Reviews
Evolution of pathological findings in surveillance biopsies of lung transplant recipients infected with SARS-CoV-2SARS-CoV-2에 감염된 폐 이식 수혜자의 감시 생검에서 병리학적 소견의 진화Article Published on 2022-06-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Admission alteration biopsy Bronchiolitis bronchiolitis obliterans case sery coronavirus disease Coronavirus disease 2019 COVID-19 described determine Diagnosis died Evolution Follow-up GRADE heart histology Hospitalized ICU immunofluorescence inclusion criteria infected with SARS-CoV-2 intensive care intensive care unit large cohort lung Lung injury lung transplant lung transplantation non-transplant patient non-transplant patients one patient Organizing pneumonia outcome outcomes pathologic pathological finding pathology Patient positive Prognosis Protein recipient recipients rejection respiratory pathogen SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid Society specimen subset Surveillance Symptomatic patients tested transbronchial Transplant Two patient two patients was performed [DOI] 10.1111/tid.13823 PMC 바로가기 [Article Type] Article
C57BL/6J Mice Are Not Suitable for Modeling Severe SARS-CoV-2 Beta and Gamma Variant InfectionC57BL/6J 마우스는 심각한 SARS-CoV-2 베타 및 감마 변종 감염을 모델링하는 데 적합하지 않습니다.Article Published on 2022-05-052022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Alpha angiotensin Angiotensin converting enzyme-2 ARDS B.1.1.7 B.1.351 B.1.617.2 Beta body weight Body Weight Changes C57BL/6 CCR2 change changes clinical disease deficiency Delta entry of SARS-CoV-2 eosin Evidence evidence of examined expression Gamma H&E H&E staining hACE2 hACE2 receptor hematoxylin histology IHC IHC staining immune immune deficiency Immunocompromised immunocompromised mice immunohistochemistry indicated infect Infection lung Lung pathology mice modeling Mutation P.1 pathologic pathological change pathological changes Probability qPCR RAG2 receptor replicate required SARS-CoV-2 SARS-CoV-2 variants severe COVID-19 shown staining survival These data three group three groups transgenic mice Transmissibility variant variants variants of concern variants of SARS-CoV-2 Viral antigen Viral protein viral titer virulence VoC VOCs weight loss were used [DOI] 10.3390/v14050966 PMC 바로가기 [Article Type] Article
Short- and mid-term multidisciplinary outcomes of newborns exposed to SARS-CoV-2 in utero or during the perinatal period: preliminary findingsObservational Study Published on 2022-04-012022-10-04 Journal: European journal of pediatrics [Category] COVID19(2023년), SARS, 임상, [키워드] Abnormalities Anomaly assessments Audiological evaluation Brainstem chain children Clinical outcome Cohort COVID-19 disease enrolled evoked otoacoustic emission Fluorescein Follow-up Fundus growth hypofluorescence immature in utero independent Infant Long-term outcomes longitudinal study microbiologically mother nasopharyngeal Nasopharyngeal swab Neonatal neurologic neurological Newborn Newborns offered outcome pathologic performed positive Pregnancy pregnant women preliminary finding reaction reduced repeated response SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV2 serologic testing Seven single-center Symptoms tested threshold transmission of SARS-CoV-2 Vascular visual acuity women [DOI] 10.1007/s00431-021-04319-1 PMC 바로가기 [Article Type] Observational Study
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 ExpressionK18-hACE2 마우스의 치명적인 신경 보급 및 SARS-CoV-2 향성은 hACE2 발현에 부분적으로만 의존합니다Article Published on 2022-03-052022-09-11 Journal: Viruses [Category] SARS, 치료기술, [키워드] ACE2 ACE2 protein ACE2-expressing cell ACE2-expressing cells Analysis angiotensin animal animal models AT1 axonal transport blood-brain barrier Brain bronchiolar Cell Cohort comparative pathology COVID-19 Critical cytokeratin cytokeratin 18 promoter days post-infection death Dependent detectable dose ENhance epidemiological data euthanasia evaluated Evidence expressing expression hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hypothermia immunohistochemistry In situ hybridization in vivo in vivo imaging independent independent of inoculated intranasal K18-hACE2 Lineage Mild-to-moderate neuroepithelium Neuron neurons occur olfactory olfactory bulb olfactory neuroepithelium overexpression pathologic PFUs Pneumocytes Pneumonia portal question resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis spatiotemporal subsequent transgenic mice translational translational animal model Transmission transmission electron microscopy Transport tropism vasculature viral pathogenesis Viremia Virological [DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article
Remitting neuropsychiatric symptoms in COVID-19 patients: Viral cause or drug effect?COVID-19 환자의 신경 정신병 증상 완화 : 바이러스 성 원인 또는 약물 효과?Article Published on 2022-03-012022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome Chloroquine clinically Complication coronavirus coronavirus disease Corticosteroids COVID-19 COVID-19 patients Dexamethasone disease FIVE Infection Mental Neuropsychiatric neuropsychiatric. Numerous pathologic patients with SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection Symptom Symptoms [DOI] 10.1002/jmv.27443 PMC 바로가기 [Article Type] Article
Sustained Impairment in Cardiopulmonary Exercise Capacity Testing in Patients after COVID-19: A Single Center ExperienceCOVID-19 이후 환자의 심폐 운동 능력 테스트에서 지속적인 손상: 단일 센터 경험Research Article Published on 2022-03-012022-09-10 Journal: Canadian Respiratory Journal [Category] MERS, SARS, 진단, 치료기술, [키워드] acute COVID-19 Capacity cardiopulmonary exercise testing center Chronic fatigue comparable correlated COVID-19 COVID-19 infection described Deterioration Ejection fraction evaluate exercise Exercise capacity Exercise limitation experience female patient Follow-up Gas exchange Improvements Infection initial limitation limitations Limited magnetic resonance imaging male MRI objective offered oxygen pathologic Patient patients performed pulse reduced Result severity of COVID-19 Stress Symptom syndrome Testing Vascular ventilatory was related [DOI] 10.1155/2022/2466789 PMC 바로가기 [Article Type] Research Article
Impact of COVID-19 pandemic on gastrointestinal cancer diagnosis and resection: An observational studyCOVID-19 대유행이 위장관암 진단 및 절제에 미치는 영향: 관찰 연구Observational Study Published on 2022-03-012022-09-12 Journal: Clinics and research in hepatology and gastroenter [Category] MERS, SARS, 임상, 진단, [키워드] affecting analyzed ANCOVA biopsy Cancer cancer diagnosis cancers changes in cohort study Colon cancer Colorectal cancer COVID COVID-19 COVID-19 pandemic determine diagnostic endoscopy Hepatocellular carcinoma Impact impacted liver medical record Older older patient pandemic pathologic pathology Patient patients resection specimen resulting retrospective significantly specimen study period T-tests therapeutic Treatment unique Volume was used were used [DOI] 10.1016/j.clinre.2021.101839 PMC 바로가기 [Article Type] Observational Study
Focal Segmental Glomerulosclerosis (FSGS) Progressing to Collapsing Glomerulopathy in Renal Transplant Recipients With and Without COVID-19 Infection.Research article Published on 2022-03-012022-10-05 Journal: Transplantation proceedings [Category] 변종, [키워드] African American association Autopsy baseline biopsy Case report CGN Collapsing COVID-19 COVID-19 infection diagnosed with COVID-19 feature Focal gene mutations GGN glomerulopathy glomerulosclerosis HIV Infection initial kidney mechanism occur pathologic pathophysiologic Patient patients post infection progressed recipient renal reported Result Segmental serum creatinine the patient Transplant with COVID-19 worsening [DOI] 10.1016/j.transproceed.2022.02.010 [Article Type] Research article
Individualized Constellation of Killer Cell Immunoglobulin-Like Receptors and Cognate HLA Class I Ligands that Controls Natural Killer Cell Antiviral Immunity Predisposes COVID-19Genetics Published on 2022-02-222022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] absence activating acute respiratory syndrome anti-SARS-CoV-2 Antiviral antiviral immunity Asymptomatic Biomarker cause Cell characterized class Cognate Combination constellation Control controls coronavirus Coronavirus-2 COVID-19 COVID-19 cohort COVID-19 host genetics COVID-19 patient COVID-19 susceptibility Defense determine detrimental Frequency General population Genetic healthy HLA HLA association HLA class I HLA gene HLA-Bw4 Host Hypothesis individual individuals Infection Inflammatory cytokine KIR KIR receptors KIR-HLA KIR-HLA association KIR2DL2 + KIR2DS1 KIR2DS5 KIR3DL1 KIR3DL2 Ligand ligands majority maturation natural NK cell NK cell function NK cells offer outcome pathologic Patient patients hospitalized receptor reduce regulated responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility severe COVID-19 severe COVID-19 patient significantly lower subsequent tested the patient triggered variable with mild disease [DOI] 10.3389/fgene.2022.845474 PMC 바로가기 [Article Type] Genetics