The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
Preclinical study of formulated recombinant nucleocapsid protein, the receptor binding domain of the spike protein, and truncated spike (S1) protein as vaccine candidates against COVID-19 in animal models동물 모델에서 COVID-19에 대한 백신 후보로서 제형화된 재조합 뉴클레오캡시드 단백질, 스파이크 단백질의 수용체 결합 도메인 및 절단 스파이크(S1) 단백질의 전임상 연구Article Published on 2022-09-012022-09-11 Journal: Molecular immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome adjuvants alum alum adjuvant analyzed animal model antibody Antibody titers Antigen AS03 binding candidate vaccine cellular cellular immunity Cellular responses COVID-19 cytokine Cytometry cytotoxicity domain dose doses ELISA evaluated flow cytometry humoral humoral and cellular immunity IgG antibody IgG antibody titer immunization immunization program immunogenic immunogenicity injection mice Mild mild to moderate moderate N-terminal domain not neutralize nucleocapsid protein nucleoprotein pathologic preclinical study primates produced Protein protein antigens RBD Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 sera Severe acute respiratory syndrome Spike protein Strong Subunit vaccine the spike protein Vaccine vaccine candidate virus Virus neutralization VNT was performed was recorded were used [DOI] 10.1016/j.molimm.2022.06.007 PMC 바로가기 [Article Type] Article
Dysregulated naïve B cells and de novo autoreactivity in severe COVID-19Article Published on 2022-08-312022-10-05 Journal: Nature [Category] SARS, 변종, 진단, 치료법, [키워드] Activation Analysis antibody antibody secreting cell Antigen ASC Autoantigens autoreactive antibody B cell breadth clinically COVID-19 de novo dominant feature Frequency glomerular identify IgG1 immune activation implication Inflammatory Intervention membrane Mild naïve B cell nuclear pathogenic autoantibody pathologic pathway Patient persist Proteins question raising remained response reveal SARS-CoV-2 selective serological severe COVID-19 severe disease single-cell specificity subset symptom onset Tolerance Treatment [DOI] 10.1038/s41586-022-05273-0 [Article Type] Article
Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations Research Published on 2022-08-222022-10-05 Journal: Nature Communications [Category] 바이오마커, 치료법, [키워드] acute phase reactant adverse outcome approach caused cellular change Co-regulation conditions COVID-19 death defined Elevation growth hospitalized patients Human Infection Inflammation Inflammatory Ischemia laboratory measurement linear mechanism Myocardial infarction pathologic Platelet Population provide risk Sepsis tissue damage trajectory trauma WBC White blood cell [DOI] 10.1038/s41467-022-32222-2 [Article Type] Research
Role of therapeutic plasma exchange in the management of COVID-19-induced cytokine storm syndromeReview article Published on 2022-08-012022-10-05 Journal: Transfusion and apheresis science : official journ [Category] SARS, 바이오마커, 임상, 치료제, [키워드] member 13 a disintegrin and metalloproteinase with a thrombospondin type 1 motif acute respiratory syndrome ADAMTS-13a disintegrin and metalloproteinase with a thrombospondin type 1 motif American Society for Apheresis approach ARDSacute respiratory syndrome article ASFAAmerican Society for Apheresis available data benefit C-reactive protein Case series Case-control CCPCOVID-19 convalescent plasma Clinical outcome Coagulopathy conducted Controlled clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent plasma COVID-19coronavirus disease 2019 criteria Critically ill patient CRPC-reactive protein CSS CSScytokine storm syndrome Cytokine storm syndrome Cytokines D-dimer Effects Evidence excessive immune response feasibility ferritin FFPfresh frozen plasma fibrinogen level fresh frozen plasma hypercoagulable Hyperinflammatory ICUIntensive Care Unit identify IFNinterferon ILInterleukin immunomodulatory effect improvement Inflammatory factor intensive care unit interferon interleukin interleukin-6 Intervention Length of stay LOSlength of stay Lymphocyte count macrophage activation syndrome management MASmacrophage activation syndrome MODSmultiple organ dysfunction syndrome Mortality multiple organ dysfunction syndrome offer offset PaO2:FiO2pressure of arterial oxygen to fractional inspired oxygen concentration pathologic Patient patients patients with COVID-19 peer-reviewed potential clinical benefits pressure of arterial oxygen to fractional inspired oxygen concentration prevent disease progression Randomized Randomized controlled trial RCTrandomized controlled trial reduce reduce mortality resulting risk role Safe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 secondary hemophagocytic lymphohistiocytosis selected Sequential Organ Failure Assessment severe acute respiratory syndrome coronavirus 2 sHLHsecondary hemophagocytic lymphohistiocytosis SOFASequential Organ Failure Assessment TAMOFthrombocytopenia-associated multiple organ failure Therapeutic plasma exchange thrombocytopenia-associated multiple organ failure TNFTumor Necrosis Factor TPE TPEtherapeutic plasma exchange treat Treatment tumor necrosis factor while with COVID-19 [DOI] 10.1016/j.transci.2022.103433 [Article Type] Review article
Recent Progress in the Development of Opaganib for the Treatment of Covid-19Covid-19 치료를 위한 Opaganib 개발의 최근 진행 상황Review Published on 2022-07-122022-09-11 Journal: Drug design, development and therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] ABC294640 acceleration active against Administered Anti-SARS-CoV-2 Activity Antiviral antiviral activity biochemical Cancer clearance clinical trial COVID-19 pandemic decrease demonstrated development dihydroceramide desaturase disease driven by drug enzyme glucosylceramide glucosylceramide synthase Host Infection Inflammation Inflammatory diseases inhibit inhibiting mechanism metabolism Mild Mild disease moderate moderately severe COVID-19 modulation Mortality multi-organ dysfunction opaganib pandemic pathologic pathologic processes Patient patients patients hospitalized phase Progress recent regulate Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 virus Signaling sphingolipid sphingolipids sphingosine sphingosine kinase. Stress subpopulation suppresse the SARS-CoV-2 virus treat Treatment treatment protocols understanding viral proliferation virus [DOI] 10.2147/DDDT.S367612 PMC 바로가기 [Article Type] Review
COVID-19: gastrointestinal and hepatobiliary manifestationsReview article Published on 2022-07-012022-10-05 Journal: Human pathology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Colon complication of COVID-19 consequence COVID COVID-19 direct viral infection Gastrointestinal GI Tract hepatic injury Hepatitis liver manifestation Manifestations Mild pandemic pathologic pathology patients with COVID-19 Pulmonary infection reported SARS-CoV-2 Symptom viral infection [DOI] 10.1016/j.humpath.2022.07.006 [Article Type] Review article
Usefulness of chest X-rays for detecting COVID 19 pneumonia during the SARS-CoV-2 pandemicObservational Study Published on 2022-07-012022-10-05 Journal: Radiología [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] analyzed chest X-ray clinical suspicion coronavirus COVID 19 COVID19 cross-sectional Cuidados intensivos discharged English form hospital Hospitalized ICU intensive care material Mild Pandemia pandemic pathologic Patient patients hospitalized Pneumonia polymerase chain polymerase chain reaction positive Prevalence Probability prognostic prognostic variable Radiografía Radiología radiology Reacción en cadena de la polimerasa RT-PCR SARS-CoV-2 SARS-COV-2 infection sensitivity Spanish statistically significant difference the disease the SARS-CoV-2 two group variable was done x-rays [DOI] 10.1016/j.rxeng.2021.11.003 PMC 바로가기 [Article Type] Observational Study
Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center경증 COVID-19의 조기 식별을 위한 현장 진료 폐 초음파 검사: 스위스 선별 센터의 외래 환자 집단Observational Study Published on 2022-06-242022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] addition blinded clinical feature Clinical features Clinical finding Clinical findings cough COVID-19 COVID-19 negative criteria detect diagnose diagnostic diagnostic radiology Dyspnoea evaluate Features healthcare worker healthy independent Infectious diseases investigators IQR lung Lung pathology Mild multivariate logistic regression Nasopharyngeal swab nasopharyngeal swabs Outpatient outpatients pathologic Patient patients PCR point-of-care positive Predictive Predictive value presenting prospective cohort prospective observational cohort quarantine recorded reduce SARS-CoV-2 SARS-COV-2 infection secondary outcome sensitivity significantly more symptom onset Transmission Ultrasonography university with COVID-19 zone [DOI] 10.1136/bmjopen-2021-060181 PMC 바로가기 [Article Type] Observational Study
Worsening hearing was associated with higher β-amyloid and tau burden in age-related hearing loss Research Published on 2022-06-212022-10-05 Journal: Scientific Reports [Category] 바이오마커, 진단, [키워드] 95% CI adjusted Affect age Alzheimer’s disease association Brain calculated cardiovascular disease cohort study confidence interval covariate covariates cross-sectional Dementia Evidence exhibited Gender hallmark hearing loss Linear regression pathologic pathologic hallmark Patient performed pet plaque potential risk predict Research resulting the mean tomography was measured was related was used were measured worsening [DOI] 10.1038/s41598-022-14466-6 [Article Type] Research