Understanding Gene Expression and Transcriptome Profiling of COVID-19: An Initiative Towards the Mapping of Protective Immunity Genes Against SARS-CoV-2 InfectionCOVID-19의 유전자 발현 및 전사체 프로파일링 이해: SARS-CoV-2 감염에 대한 보호 면역 유전자 매핑을 위한 이니셔티브Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Against Agilent Analysis Arraystar CASC18 Characteristics Cluster cluster analysis co-expression COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients dataset DEGs determine differentially expressed differentially expressed gene Differentially expressed genes disease pathogenesis DLEU2 element Gene Expression Genetic genetic factor GEO dataset globe GNAS healthy control healthy controls help identify immune immune response initiative inter-individual interactome mapping involved lncRNA mapping Microarray Mild molecular mechanism Pathway enrichment analysis performed Potential biomarker potential biomarkers PPI PPI network Profiling protective immunity protein-coding gene protein-coding genes protein-protein interaction Regulatory regulatory genes response responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient SNHG20 statistical TALAM1 three groups transcriptome profiling UICLM understanding Variability volunteers was used [DOI] 10.3389/fimmu.2021.724936 PMC 바로가기 [Article Type] Immunology
Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing폐 질환 네트워크는 SARS-COV-2 감염에 대한 동반 질환의 영향과 약물 용도의 기회를 보여줍니다.Research Article Published on 2021-09-172022-08-31 Journal: BMC Medical Genomics [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] accelerate Algorithm Analysis approach association biological processes build Care clinical condition clinical conditions clinical evidence Community Comorbidity COVID-19 COVID-19 patient COVID-19 patients disease Disease network disorder drug Drug development functional functional protein genetic association Health Health care Health care system identify IMPROVE Lung disease Lung diseases lung disorder lung disorders Lungs molecular basis molecular feature Mortality overlap overlapped overlapping Pathway enrichment analysis Patient possession Protein Protein–protein interaction reason for respiratory Respiratory disease respiratory diseases Result reveal SARS-CoV-2 SARS-COV-2 infection similarity supplementary material target targets virus was used with COVID-19 [DOI] 10.1186/s12920-021-01079-7 PMC 바로가기 [Article Type] Research Article
The Molecular Basis of Gender Variations in Mortality Rates Associated With the Novel Coronavirus (COVID-19) OutbreakMolecular Biosciences Published on 2021-09-172022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 AGTR1 Analysis angiotensin-converting enzyme 2 Basis Characteristics CHM COVID-19 COVID-19 infection COVID-19 outbreak COVID-19 patient DDX3X differential expression differentially expressed disease disease course downregulation effective epidemiological Evidence female Female patients females FGFR3 Gender genders Genes heterogeneity hydrolase activity immune response immunological initial involved lung lung tissue lung tissues male modulation molecular basis molecular mechanism mortality rate NLRP2 novel novel coronavirus disease outbreak outcome pathway Pathway enrichment analysis Patient PTGDR2 RAS Rate receptor Regulation renin-angiotensin system sex-based immunological differences SFRP2 subpopulations target the disease therapeutic option transcriptomic data transcriptomics treat two groups upregulation Variation [DOI] 10.3389/fmolb.2021.728409 PMC 바로가기 [Article Type] Molecular Biosciences
A network-based systems biology approach for identification of shared Gene signatures between male and female in COVID-19 datasetsResearch article Published on 2021-08-182022-10-05 Journal: Informatics in Medicine Unlocked [Category] 바이오마커, 신약개발, [키워드] absence Affect Analysis app approach Biomarker category CDK1 CDK2 Cell Comorbidities Comorbidity coronavirus country COVID-19 COVID-19 virus dataset datasets death DEGs DNA Doxorubicin drug E2F1 female FN1 gene signature greater Hub-proteins Human identify Interaction involved KEGG pathway KLF5 L-alanine male maturation medication Mild miRNA moderate Mortality mortality rate Novel coronavirus Ontology Oocyte other disease overlapping Pathway enrichment analysis peripheral blood cell PPARG PPI network Respiratory system retrieved risk factor RNAseq robust Robust voom roscovitine SARS-CoV-2 Serine severe symptom Sex Sex-specific biomarkers SP1 Still suggested SUMO2 Symptoms Systems biology Tamoxifen therapeutic agent TP53 treat UBC Vaccine women [DOI] 10.1016/j.imu.2021.100702 [Article Type] Research article
Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection프로바이오틱스의 항바이러스 메커니즘에 대한 체계적인 네트워크 및 메타 분석: SARS-CoV-2 감염을 완화하기 위한 예방 및 치료 전략Comment Published on 2021-08-012022-09-11 Journal: Probiotics and antimicrobial proteins [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Activation affecting Analysis association biological network Biological network analysis boosting immunity candidate gene Clinical outcome common cold Comorbidities concerning country COVID-19 deaths domain functional Glucose Gut gut microbiome gut microbiota gut-lung axis Immune cell immune system immunomodulatory Immunosuppressed implementation IMPROVE individuals with COVID-19 infect infected case infected cases lung cells Lung infection lung tissue Meta-analysis metabolic pathway Microbiome Migration modulating molecular target network NLRP3 offer pandemic Pathway enrichment analysis Pathways Pneumonia Probiotics Prognosis rationale Respiratory illness resulting SARS-CoV-2 severity shown specific treatment Strategy systemic immune response the disease therapeutic effect therapeutic effects therapeutic strategy treating COVID-19 Treatment viral infection virus virus entry with COVID-19 [DOI] 10.1007/s12602-021-09748-w PMC 바로가기 [Article Type] Comment
Blue Biotechnology: Computational Screening of Sarcophyton Cembranoid Diterpenes for SARS-CoV-2 Main Protease InhibitionBlue Biotechnology: SARS-CoV-2 주요 프로테아제 억제를 위한 Sarcophyton Cembranoid Diterpenes의 컴퓨터 스크리닝Comparative Study Published on 2021-07-132022-09-10 Journal: Marine Drugs [Category] SARS, 비임상, [키워드] ACE Achille affected Analysis Antiviral antiviral agent antiviral drug antiviral drugs assembly binding binding affinities binding affinity binding energy Bioavailability biochemical blue breath cembranoid diterpenes metabolites characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment darunavir database died diterpene drug Effects enrichment analysis ESR1 established therapy examined FIVE genus genus Sarcophyton HIV protease inhibitor in silico in vitro in vivo indicate inhibit inhibition inhibitor inhibitors M pro manifested MAPK MAPK14 MD simulations metabolite molecular molecular docking molecular dynamics Molecular mechanics over pandemic pathway Pathway enrichment analysis polyprotein protease protein-protein interaction Reactome robust SARS-CoV-2 SARS-CoV-2 main protease screened Screening Signaling STRING database surface area Treatment Viral viral replication [DOI] 10.3390/md19070391 PMC 바로가기 [Article Type] Comparative Study
Porcine Epidemic Diarrhea Virus Induces Vero Cell Apoptosis via the p53-PUMA Signaling PathwayArticle Published on 2021-06-242022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activate addition African green monkey Analysis annotation Apoptosis apoptosis pathways BAX/Bcl-2 Blotting differentially expressed gene effective epidemic diarrhea expression flow cytometry Genome Illumina immune in vitro induce Infection Inflammation inhibit inhibitor inoculated KEGG Kyoto MAPK signaling mechanism p53 p53 signaling pathway pathogenic pathway Pathway enrichment analysis PEDV Porcine epidemic diarrhea virus promote Proteins puma qRT-PCR Randomly reported screened selected Sequencing shown signaling pathway significantly significantly increased Support target gene TNF signaling total RNA transcriptome sequencing Vaccine Vero Vero Cell was performed [DOI] 10.3390/v13071218 PMC 바로가기 [Article Type] Article
The risk of pancreatic adenocarcinoma following SARS-CoV family infectionSARS-CoV 가족 감염 후 췌장 선암의 위험Article Published on 2021-06-212022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, 치료법, [키워드] Actin Analysis applied Cancer cancer development candidate gene carried CASP3 claimed Complication correlation COVID 19 CREB1 Cytoscape database dataset defined differentially expressed gene Differentially expressed genes disease down-regulated gene down-regulated genes evaluate followed by functional Gene ontology Genes GEO database group H1N1 identification identify in-silico Infection infection with SARS-CoV-2 Interaction involved malignancy molecular Ontology pancreatic Pathway enrichment analysis predict Proteins PTEN Research risk RNA SARS-CoV SARS-CoV virus SARS-CoV viruses screened Smad3 statistically significant STRING the disease up-regulated Vaccine viral infection viruses was selected were used [DOI] 10.1038/s41598-021-92068-4 PMC 바로가기 [Article Type] Article
Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19Article Published on 2021-05-052022-10-04 Journal: Scientific Reports [Category] SARS, 임상, 치료제, [키워드] alleviate analyzed anti-inflammatory agents anti-inflammatory drug approach approved binding affinity Biotechnology Cell Clinical efficacy Computational biology and bioinformatics Coronavirus disease 2019 COVID-19 docking score drug enrichment analysis excessive inflammation exhibited FDA food genetics Health care highest indomethacin inhibition KEGG Kyoto MAPK10 MAPK8 mechanism Medical research Molecular biology molecular docking network network pharmacology NSAID NSAIDS overlapping Pathway enrichment analysis Patient prediction proinflammatory Protein PubChem RAS Rofecoxib RStudio SARS-CoV-2 selected signaling pathway target target protein target proteins the binding affinity tissue Venn diagram was determined were used [DOI] 10.1038/s41598-021-88313-5 PMC 바로가기 [Article Type] Article
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19실행 가능한 약물 가능 게놈 전체 멘델식 무작위화, COVID-19의 용도 변경 기회 식별Article Published on 2021-04-012022-09-11 Journal: Nature Medicine [Category] MERS, SARS, 바이오마커, 변종, 비임상, 신약개발, 유전자 메커니즘, 임상, 진단, 치료법, 치료제, [키워드] ACE2 approach approved drug approved drugs association Colocalization conducted controls COVID-19 COVID-19 hospitalization drug Drug development drugs targeting Evidence expression genetic instrument genetic instruments Hospitalization identify IFNAR2 IL10RB initiative loci management mendelian randomization Mendelian randomization analyses Million Veteran Program Pathway enrichment analysis patients hospitalized Protein proteomic provide Quantitative suggested therapeutic target therapeutic targets Therapeutics transcriptomic Trial with COVID-19 [DOI] 10.1038/s41591-021-01310-z PMC 바로가기 [Article Type] Article