Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial CellsSARS-COV-2의 스파이크 단백질은 뇌 내피 세포에서 분자 전달 및 대사 기능에서 병리학 적 변화를 유도한다.Article Published on 2021-10-082022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 BBB Blood–brain barrier Brain cause change changes in component components coronavirus coronavirus disease COVID-19 delivery dextran drastic Effect Endothelial cell endothelial cells enzyme Express function functional host cells induce infected with SARS-CoV-2 infecting infectious agent infectious agents marker mechanism metabolic metabolic function metabolism mitochondrial molecular neurological sign neurological signs Neurological symptom Neurological symptoms pathogenic pathological pathological mechanism permeability physiological RBD recent receptor Receptor-binding domain respiratory S1 domain SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown spike Spike protein the receptor-binding domain toxic effect toxic effects Transferrin Treatment trimer was increased [DOI] 10.3390/v13102021 PMC 바로가기 [Article Type] Article
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alterationSARS-CoV-2는 밀착 접합 변경 없이 기저막 파괴와 함께 혈액-뇌 장벽을 통과합니다.Article Published on 2021-09-062022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 치료기술, 치료제, [키워드] accompanied Activation administration astrocytes basement membrane blood-brain barrier Blood–brain barrier Brain brains collagen cross Endothelial cell endothelial cells Evan Evans blue Evidence Experimental models of disease expression hACE2 hamster Human in vitro in vivo experiments infect Inflammatory factor inflammatory factors Inflammatory response Inflammatory responses K18-hACE2 transgenic mice marker membrane MMP9 not altered occludin occurred pathway perivascular permeability reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA tight junction tight junctions transcellular pathway ultrastructure upregulated Vascular Vasculitis vessel was increased ZO-1 [DOI] 10.1038/s41392-021-00719-9 PMC 바로가기 [Article Type] Article
Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application블레오마이신 유발 폐섬유증에 대한 간엽줄기세포의 유효성: 체계적인 검토 및 임상적용 시사점Review Published on 2021-08-232022-09-10 Journal: Stem Cell Research & Therapy [Category] MERS, 유전자 메커니즘, [키워드] acute lung injury acute respiratory syndrome Bacterial Bleomycin cells clinical clinical evidence Clinical research clinical trial clinical trials collagen coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 Critically ill cytokine damaged disease effective Effectiveness endothelial epithelial cells expression Extracellular matrix Factors fibrosis growth Idiopathic pulmonary fibrosis IMPROVE inflammatory cell inflammatory cell infiltration Inflammatory cytokine Inflammatory response inhibiting interstitial interstitial disease IPF life lung Lung injury lung tissue Mesenchymal stem cells Middle East Middle East respiratory syndrome Migration MOST MSC MSCs paracrine Patient permeability poor prognosis potential mechanism preclinical studies preclinical study Prognosis pulmonary pulmonary fibrosis Quality of life reduce reducing Research respiratory SARS-CoV-2 SARS-COV-2 infection secretion Severe acute respiratory syndrome STEM stem cell stem cells Support systematic review therapeutic tissue repair transformation Treatment Trial viral-induced [DOI] 10.1186/s13287-021-02551-y PMC 바로가기 [Article Type] Review
Role of Extracellular Vimentin in Cancer-Cell Functionality and Its Influence on Cell Monolayer Permeability Changes Induced by SARS-CoV-2 Receptor Binding DomainArticle Published on 2021-07-122022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activated macrophages Activation activation pathway addition Alter angiotensin-converting enzyme 2 Astrocyte Bacterial bind binding binding domain Cancer Cancer cells cancer progression Cell Cell migration cells cellular change cytoskeletal domain Effect ENhance Extracellular extracellular space extracellular vimentin functional functions growth IGF-1 IGF-1 receptor induced Inflammation influence investigated involved MCF-7 Migration modulate modulation monolayer monolayers neutrophil infiltration overexpressed permeability physiological conditions proliferation promote Protein receptor Receptor binding domain reduced reduction role SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 receptor SARS-COV-2 receptor binding domain SARS-CoV-2 spike protein secreted shown Spike protein Support surface the SARS-CoV-2 Treatment vimentin viral infection while [DOI] 10.3390/ijms22147469 PMC 바로가기 [Article Type] Article
Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients중증 COVID-19 환자의 장 투과성 장애를 나타내는 혈장 표지자Immunology Published on 2021-06-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] applied approach Bacterial Blood cause clinical implications contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Crosstalk disease severity Diseases disrupt Disrupted Disruption exacerbate functions fungal glycome glycomics Gut gut barrier integrity highlight immune activation implicated Inflammation Injury intestinal investigated Lipidomics lung Lung injury marker metabolome metabolomics microbe microbes microbial microbial translocation mortality rate negative controls permeability Plasma marker plasma markers plasma metabolome plasma sample plasma samples positive positive feedback resulting SARS-CoV-2 severe coronavirus disease severe COVID-19 severity systemic inflammation Systems biology tight junction translocation zonulin [DOI] 10.3389/fimmu.2021.686240 PMC 바로가기 [Article Type] Immunology
The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage InteractionsOriginal Article Published on 2021-03-102024-09-04 Journal: Journal of Crohn's and Colitis [Category] 대상포진, [키워드] epithelial cells IBD Jak-STAT Macrophage permeability TCPTP tight junction [DOI] 10.1093/ecco-jcc/jjaa182 PMC 바로가기 [Article Type] Original Article
On Drug-Membrane Permeability of Antivirals for SARS-CoV-2SARS-CoV-2에 대한 항바이러스제의 약물-막 투과성Article Published on 2021-02-112022-09-11 Journal: The journal of physical chemistry letters [Category] 치료제, [키워드] approach Behavior Bioavailability cellular organelles Characteristics Combination composed Compound contribute coronavirus determine drug drug design drugs effective drug effective drugs Efficacy endoplasmic reticulum membranes FIVE flexible Golgi highlight identify Interaction mammalian membrane membrane permeability membranes mitochondrial molecular dynamics Molecular dynamics simulation molecules negative correlation parameter permeability permeation plasma predict Proteins required SARS-CoV-2 Spike protein statistical analysis targets transmembrane variety Viral viral envelope [DOI] 10.1021/acs.jpclett.0c02397 PMC 바로가기 [Article Type] Article
Altered high-density lipoprotein composition and functions during severe COVID-19심각한 COVID-19 동안 변경된 고밀도 지단백질 구성 및 기능Article Published on 2021-01-272022-09-10 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Admission affecting Alpha Altered amyloid A Analysis Anti-inflammatory antioxidant antitrypsin Apolipoprotein Apoptosis Biomarkers cadherin changes in conditions consequence controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Day Decreased Endothelial cell endothelial cells exposure to function HDL HDL-C HDLs healthy subjects high-density initial intensive care intensive care unit less lipid metabolism mass spectrometry pandemic Particle Patient patients worldwide permeability plasma Protective Protein proteome Proteomic analysis proteomics pulmonary damage reported SARS-CoV-2 serum amyloid severe COVID-19 severe COVID-19 patient severe COVID-19 patients Sex TNFα VE-cadherin viral infection was performed [DOI] 10.1038/s41598-021-81638-1 PMC 바로가기 [Article Type] Article
Pre-Existing Cytokine and NLRP3 Inflammasome Activation and Increased Vascular Permeability in Diabetes: A Possible Fatal Link With Worst COVID-19 Infection Outcomes?Immunology Published on 2020-11-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] COVID-19 cytokine diabetes glycocalyx Increased Inflammasome Inflammation NLRP3 permeability Worst [DOI] 10.3389/fimmu.2020.557235 PMC 바로가기 [Article Type] Immunology
HIF-1α is involved in blood–brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitisHIF-1α는 폐렴구균 수막염에서 혈액-뇌 장벽 기능 장애와 세포 간 박테리아 이동에 관여한다.Original Paper Published on 2020-06-112024-07-31 Journal: Acta Neuropathologica [Category] 폐렴구균 감염증, [키워드] blood–brain barrier (BBB) Dexamethasone Endothelium HIF-1α Meningitis Paracellular transmigration permeability S. pneumoniae VEGF [DOI] 10.1007/s00401-020-02174-2 PMC 바로가기 [Article Type] Original Paper