Active ingredients Isorhamnetin of Croci Srigma inhibit stomach adenocarcinomas progression by MAPK/mTOR signaling pathwayarticle Published on 2023-08-032024-09-05 Journal: Burma Med J [Category] update2024, [키워드] Gastric cancer Pharmacodynamics [DOI] 10.1038/s41598-023-39627-z PMC 바로가기 [Article Type] article
Based on network pharmacology and bioinformatics to analyze the mechanism of action of Astragalus membranaceus in the treatment of vitiligo and COVID-19article Published on 2023-03-082024-09-05 Journal: Burma Med J [Category] update2024, [키워드] Pharmacodynamics Pharmacology Vitiligo [DOI] 10.1038/s41598-023-29207-6 PMC 바로가기 [Article Type] article
Viral clearance, pharmacokinetics and tolerability of ensovibep in patients with mild to moderate COVID-19: A phase 2a, open-label, single-dose escalation studyClinical Trial Published on 2023-03-012023-07-10 Journal: British Journal of Clinical Pharmacology [Category] COVID19(2023년), [키워드] COVID-19 medication safety Pharmacodynamics pharmacokinetics Virology [DOI] 10.1111/bcp.15560 PMC 바로가기 [Article Type] Clinical Trial
Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammationarticle Published on 2023-01-132024-09-05 Journal: Nature Communications [Category] update2024, [키워드] antivirals Pharmacodynamics RNA SARS-CoV-2 [DOI] 10.1038/s41467-023-35928-z PMC 바로가기 [Article Type] article
Pharmacokinetic and Pharmacodynamic Effects of Polyclonal Antibodies against SARS-CoV2 in MiceArticle Published on 2022-12-302023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] COVID-19 mouse model Pharmacodynamics pharmacokinetics [DOI] 10.3390/v15010123 PMC 바로가기
Why Molnupiravir Fails in Hospitalized PatientsArticle Published on 2022-12-202023-07-10 Journal: mBio [Category] COVID19(2023년), [키워드] antivirals hollow fiber infection model molnupiravir Pharmacodynamics SARS-CoV-2 [DOI] 10.1128/mbio.02916-22 PMC 바로가기
EDP-514 in healthy subjects and nucleos(t)ide reverse transcriptase inhibitor-suppressed patients with chronic hepatitis BArticle Published on 2022-12-012023-06-13 Journal: Antiviral therapy [Category] B형 간염, [키워드] capsid assembly modulator Chronic Hepatitis B core inhibitor core protein allosteric modulator Hepatitis B virus Pharmacodynamics pharmacokinetics Safety [DOI] 10.1177/13596535221127848
Interactions of the protease inhibitor, ritonavir, with common anesthesia drugsArticle Published on 2022-10-012022-11-15 Journal: Paediatric anaesthesia [Category] 치료제, [키워드] administration adverse effect affected Altered Anesthesia Antiviral antiviral drug approach Bioavailability change changes in children clearance Combination Comorbidities Concentration COVID-19 dependent on drug drug clearance drug dose Drug interactions early treatment enzyme example fentanyl increase in inhibited inhibitor inhibitory intrinsic management metabolic pathways pathway Patient Pharmacodynamics pharmacokinetic plasma concentration propofol Protease inhibitor remifentanil responsible Ritonavir subject Variability [DOI] 10.1111/pan.14529 PMC 바로가기
Understanding the Pharmacology of COVID-19 mRNA Vaccines: Playing Dice with the Spike?Article Published on 2022-09-172022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, 진단, [키워드] adverse effects Antigen complex conventional vaccines COVID-19 COVID-19 mRNA vaccine Dice drug Effect emergency condition Evidence implication mechanism of action mRNA mRNA vaccine mRNA vaccines Pharmacodynamics pharmacokinetic pharmacokinetics Pharmacology representing resulting S protein Safe Safety Safety assessment SARS-CoV-2 SARS-CoV-2 S protein Spike protein the SARS-CoV-2 took place translation undergo understanding vaccination [DOI] 10.3390/ijms231810881 PMC 바로가기
Characterizing SARS-CoV-2 Viral Clearance Kinetics to Improve the Design of Antiviral Pharmacometric StudiesSARS-CoV-2 바이러스 제거 동역학 특성화를 통해 항바이러스 약리학적 연구 설계 개선Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] analyzed Antiviral antiviral drug antiviral drugs antiviral effects antiviral treatments assessment clearance clearance rate clinical trials conducted Consensus COVID-19 illness Effect estimate exponential decay model individuals Infection Kinetics methodology Metrics molnupiravir Nasopharyngeal swab Nasopharyngeal swab samples Nirmatrelvir Patient Pharmacodynamics Phase 2 profile provide qPCR randomized trial randomized trials reduced reported robust Sample size sample sizes SARS-CoV-2 splines Statistical power time to clearance. Trial viral clearance Viral load virological response [DOI] 10.1128/aac.00192-22 PMC 바로가기 [Article Type] Article