A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer’s DiseaseResearch Published on 2024-07-052024-09-05 Journal: Alzheimer's Research & Therapy [Category] update2024, [키워드] Alzheimer’s disease Amyloid beta protein app clinical trial Pharmacodynamics [DOI] 10.1186/s13195-024-01490-z PMC 바로가기 [Article Type] Research
A Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritisResearch Published on 2024-06-062024-09-05 Journal: Arthritis Research & Therapy [Category] update2024, [키워드] B-cell depletion CXCR5 Efficacy Follicular helper T cells depletion PF-06835375 Pharmacodynamics pharmacokinetics rheumatoid arthritis Safety systemic lupus erythematosus [DOI] 10.1186/s13075-024-03337-2 PMC 바로가기 [Article Type] Research
A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with Early Alzheimer’s DiseaseArticle Published on 2024-03-222024-09-05 Journal: medRxiv [Category] update2024, [키워드] Alzheimer’s disease Amyloid beta protein app clinical trial Pharmacodynamics [DOI] 10.1101/2024.03.20.24304638 PMC 바로가기 [Article Type] Article
A novel, small-volume subcutaneous furosemide formulation delivered by an abdominal patch infusor device in patients with heart failure: results of two phase I studiesarticle Published on 2024-01-062024-09-05 Journal: European heart journal. Cardiovascular pharmacothe [Category] update2024, [키워드] furosemide heart failure intravenous Pharmacodynamics pharmacokinetics Subcutaneous [DOI] 10.1093/ehjcvp/pvad073 PMC 바로가기 [Article Type] article
Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug DeliveryReview Published on 2023-12-292024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] cell-free therapeutics Extracellular vesicles lipid bilayer vesicles nano-biocarriers pharmaceutical applications/drug delivery Pharmacodynamics pharmacokinetics [DOI] 10.3390/ijms25010485 PMC 바로가기 [Article Type] Review
Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseasesReview Article Published on 2023-12-212024-09-05 Journal: Cell Death & Disease [Category] update2024, [키워드] Pharmacodynamics Small molecules [DOI] 10.1038/s41419-023-06370-2 PMC 바로가기 [Article Type] Review Article
Achillea millefolium : Mechanism of action, pharmacokinetic, clinical drug-drug interactions and tolerabilityReview Article Published on 2023-11-302024-09-05 Journal: Heliyon [Category] update2024, [키워드] Achillea millefolium Drug interactions mechanism of action Pharmacodynamics pharmacokinetics Toxicity [DOI] 10.1016/j.heliyon.2023.e22841 PMC 바로가기 [Article Type] Review Article
Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19article Published on 2023-09-282024-09-05 Journal: Burma Med J [Category] update2024, [키워드] biostatistics clinical pharmacology Drug development Infectious diseases Pharmacodynamics pharmacokinetics Phase III trials Randomized controlled trials Respiratory tract diseases [DOI] 10.1038/s41598-023-43412-3 PMC 바로가기 [Article Type] article
A randomized trial comparing LY01011, biosimilar candidate, with the reference product denosumab (Xgeva®) in healthy Chinese subjectsResearch Paper Published on 2023-09-012024-09-04 Journal: Journal of Bone Oncology [Category] 대상포진, [키워드] Bone metastasis Denosumab biosimilar immunogenicity Pharmacodynamics pharmacokinetics Safety [DOI] 10.1016/j.jbo.2023.100499 PMC 바로가기 [Article Type] Research Paper
A phase I, first-in-human study to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of MRG-001 in healthy subjectsarticle Published on 2023-08-252024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] clinical trial healthy volunteers MRG-001 Pharmacodynamics pharmacokinetics Phase I Plerixafor Safety stem cells tacrolimus [DOI] 10.1016/j.xcrm.2023.101169 PMC 바로가기 [Article Type] article