Persistent Lung Injury and Prothrombotic State in Long COVIDReview Published on 2022-04-072023-07-08 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] anticoagulation COVID-19 Long COVID Phosphatidylserine therapy thrombosis [DOI] 10.3389/fimmu.2022.862522 PMC 바로가기 [Article Type] Review
Long COVID: The Nature of Thrombotic Sequelae Determines the Necessity of Early AnticoagulationReview Published on 2022-04-052023-07-08 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), [키워드] chronic hypoxia early anticoagulation endothelial injury Extracellular vesicles Inflammation Long COVID Phosphatidylserine thrombosis [DOI] 10.3389/fcimb.2022.861703 PMC 바로가기 [Article Type] Review
Red Blood Cell Abnormalities as the Mirror of SARS-CoV-2 Disease Severity: A Pilot StudyPhysiology Published on 2022-01-202022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] abnormality activate Admission age Analysis Anemia apoptotic association biochemical Blood calcium ion Care caspase-3 Cell cell clearance Chest Chest CT chest infiltration coagulation analysis component Concentration Control control group controls correlated COVID-19 COVID-19 disease COVID-19 patients dehydrogenase demographic Diagnosis disease disease severity distribution Effect elevated enzyme erythrocyte evaluated exhibited expressed feature flow cytometry free hemoglobin G6PD G6PDH H b healthy controls healthy subject healthy volunteer hemoglobin Hemolysis hepatic impairment hospitalized patient hypoxia IgG IgGs Immunoglobulin infiltration Intracellular Laboratory LDH Lung function male malignancy marker material mechanical stress mechanism membrane-bound Mirror osmotic oxidative pathophysiology Patient patients performed Peripheral blood Phosphatidylserine pilot study plasma Protein pulmonary CT pulmonary infiltrate RBC RBCs reactive Red red blood cell renal Result ROS SARS-CoV-2 SARS-COV-2 infection senescent serum severe COVID-19 disease severity significant effect significantly significantly lower the disease the mean the patient the SARS-CoV-2 thrombotic Treatment virus was used were measured were recorded with COVID-19 [DOI] 10.3389/fphys.2021.825055 PMC 바로가기 [Article Type] Physiology
Circulating Microparticles in the Pathogenesis and Early Anticoagulation of Thrombosis in COVID-19 With Kidney InjuryCell and Developmental Biology Published on 2022-01-182022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] abnormality Activation Acute kidney injury affecting aggravate anticoagulant therapy anticoagulation Apoptosis binding site Blood blood cell blood circulation blood flow velocity can be used caused cells circulating clinical manifestations clinical outcomes clinical study Coagulation coagulation cascade Coagulopathy complexes consequence COVID-19 COVID-19 infection cytokine damaged cells dead Diseases early anticoagulation endothelial injury hospital hypercoagulability Immune cell impaired function IMPROVE inflammatory factors Injury kidney Kidney injury mechanism membrane Microparticle Mortality oxygen pandemic pathophysiological mechanism Patient Perspective Phosphatidylserine platform predict progression Prophylactic provide reduce rehabilitation released renal resulting risk factor thrombosis Treatment Vascular vascular endothelial cells viruses [DOI] 10.3389/fcell.2021.784505 PMC 바로가기 [Article Type] Cell and Developmental Biology
The Central Role of Extracellular Vesicles in the Mechanisms of Thrombosis in COVID-19 Patients With Cancer and Therapeutic StrategiesCell and Developmental Biology Published on 2022-01-122022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] activate aggravate amplification amplify Antithrombotic antithrombotic therapy Apoptosis benefit Blood blood cell Blood coagulation blood flow Cancer Cell clinical manifestations Coagulation coagulation cascade contribute contributing to COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines storm early stage Endothelial cell facilitate highlight Immune cell incidence maintain mechanism Microparticle microparticles microthrombi Mortality oxygen saturation pathophysiological mechanism pathway Patient Phosphatidylserine positive feedback loop proinflammatory cytokines promote resulting role SARS-CoV-2 susceptibility severe COVID-19 infections Strategy subsequent suggested the disease thrombosis thrombus formation treatment strategy tumor cell Venous thrombosis viral clearance virus [DOI] 10.3389/fcell.2021.792335 PMC 바로가기 [Article Type] Cell and Developmental Biology
Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patientsPBMC에 의한 포스파티딜세린 양성 미세입자의 결합은 COVID-19 환자의 질병 중증도를 분류합니다Article Published on 2021-12-012022-09-11 Journal: Journal of Extracellular Vesicles [Category] 유전자 메커니즘, [키워드] activated addition Affect Apoptosis blood cell Blood cells Blood coagulation carried cascade CD8 CD8+ CD8+ T cells cells Clinical course Coagulation complement complement system correlated strongly COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients disease severity distribution dying cells Frequency gene expression signature immune cells immune dysfunction Inflammation Inflammatory responses initial investigated Laboratory leucocyte lymphocyte Lymphocytes lymphopenia marker memory T cells Microparticle occur Patient PBMC PBMCs PD-L1 Phosphatidylserine Platelet platelet-derived microparticle Platelets SARS-CoV-2 severe lymphopenia T cell T cells Thromboinflammation thrombotic [DOI] 10.1002/jev2.12173 PMC 바로가기 [Article Type] Article
Phosphatidylserine receptors enhance SARS-CoV-2 infection포스파티딜세린 수용체는 SARS-CoV-2 감염을 강화합니다Research Article Published on 2021-11-192022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 치료기술, [키워드] Ablation ACE2 adhere airway apoptotic apoptotic bodies bemcentinib Betacoronavirus binding cathepsin Cell cell line cell surface receptor cell surface receptors cells contrary coronavirus correlated detect detectable Endosomal acidification ENhance entry of SARS-CoV-2 evaluated Evidence Express expressed expression facilitate facilitated Host human lung identify Infection inhibit SARS-CoV-2 inhibited inhibitor inhibitors Interaction internalization knockout Liposome mechanism MHV mouse hepatitis mouse hepatitis virus murine mutant observation pandemic coronavirus Phosphatidylcholine Phosphatidylserine pseudovirion purified receptor receptors reduce reduced SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 virions Signaling small molecule small molecule inhibitor Small molecule inhibitors Support TAM the SARS-CoV-2 therapeutic potential Vero E6 Vero E6 cell VERO E6 cells virion virus virus entry virus infection viruses [DOI] 10.1371/journal.ppat.1009743 PMC 바로가기 [Article Type] Research Article
Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19자가 면역 항 DNA 및 항 포스파티딜 세린 항체는 심각한 COVID-19의 발병을 예측합니다Research Article Published on 2021-09-092022-09-10 Journal: Life Science Alliance [Category] MERS, SARS, 바이오마커, 진단, [키워드] accounted Analysis antibody autoantibodies autoantibody Autoimmune autoimmune antibodies autoimmune antibody Biomarker cell injury clinical manifestation clinical manifestations Coagulation correlated strongly correlation COVID-19 COVID-19 patient COVID-19 patients disease severity DNA erythrocytes Hospital admission hospitalized patient IgG in some induce lysate marker neutrophil Pathogenesis pathogenesis of COVID-19 Patient patients performed Phosphatidylserine positive Positive predictive value predict Predictive Predictive value Retrospective study severe cases severe COVID-19 severe disease severity statistical analysis [DOI] 10.26508/lsa.202101180 PMC 바로가기 [Article Type] Research Article
Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopeniaSARS-CoV-2 백신 접종과 관련된 면역 혈전성 혈소판 감소증에서 항체 매개 응고촉진 혈소판Article Published on 2021-08-012022-09-12 Journal: Haematologica [Category] MERS, SARS, 진단, [키워드] administration Admission aggregation analyzed antibody assays Autopsy capillary ChAdOx1 nCoV-19 COVID-19 pandemic COVID-19 vaccination enzyme female flow cytometry glomerular healthy healthy volunteer immune immunological male median median age morbidity and mortality organ outcome P-selectin Pathogenesis Patient performed PF4 Phosphatidylserine Platelet platelet activation Prevent procoagulant procoagulant marker SARS-CoV-2 vaccine Severe infection significant increase thrombotic thrombotic complication treated vaccination Vaccine venous volunteers [DOI] 10.3324/haematol.2021.279000 PMC 바로가기 [Article Type] Article
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytiaTMEM16 단백질을 억제하는 약물은 SARS-CoV-2 스파이크 유도 융합체를 차단합니다Article Published on 2021-06-012022-09-11 Journal: Nature [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] Activation alveolar approved drug calcium Cell Cell fusion cell surface Characteristics COVID-19 COVID-19 disease defined Deterioration diarrhoea disease drug effective effective drug effective drugs include Inflammatory response inhibit inhibited inhibitor inhibitors ion channel lung Lung function Lungs membrane membrane conductance morphology niclosamide oedema Pathogenesis patients with COVID-19 performed pharmacological Phosphatidylserine plasma membrane pneumocyte potential mechanism Protein repurposing responsible SARS-CoV-2 SARS-CoV-2 spike protein Screening screenings Spike protein Support Syncytia the cell the SARS-CoV-2 therapy thrombosis unique virus replication [DOI] 10.1038/s41586-021-03491-6 PMC 바로가기 [Article Type] Article