Development of nanoparticle-delivery systems for antiviral agents: A review항바이러스제용 나노입자 전달 시스템 개발: 검토Review Published on 2021-03-102022-08-31 Journal: Journal of controlled release : official journal o [Category] SARS, 치료제, [키워드] Antiviral antivirals Bioavailability can be used caused Characteristics COVID-19 pandemic death described development dimensions Effect effective Efficacy Factor handling Health highlight IMPROVE increases in infections lipids morphology Nanoparticles Nanotechnology overcome pandemic Phospholipids polysaccharides potency problem Proteins public health recent reducing SARS-CoV-2 Sickness Side effects stability Viral viral infections Viral transmission virus viruses [DOI] 10.1016/j.jconrel.2021.01.017 PMC 바로가기 [Article Type] Review
Diffusion and Relaxation Edited Proton NMR Spectroscopy of Plasma Reveals a High-Fidelity Supramolecular Biomarker Signature of SARS-CoV-2 Infection플라즈마의 확산 및 이완 편집된 양성자 NMR 분광법은 SARS-CoV-2 감염의 고충실도 초분자 바이오마커 시그니처를 보여줍니다Article Published on 2021-03-022022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 바이오마커, 진단, [키워드] age-matched control Analysis applied Biomarker carried choline classification Combination Comparator group component Concentration Control COVID-19 diagnostic diagnostics discriminant analysis elevated experiments following functional Functional assessment glycoprotein Glycoproteins healthy high-density High-density lipoprotein Hospitalized identity low-density Low-density lipoprotein Magnetic resonance spectroscopy marker metabolite metabolites molecular molecular markers negative patients NMR not significantly different nuclear nuclear magnetic resonance Patient patients phospholipid Phospholipids plasma positive Principal component principal component analysis proton Receiver operator characteristic reduced Relaxation respiratory rRT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patient SARS-CoV-2 positive patients SARS-CoV-2 positivity selected signature significantly Spectroscopy statistical Structure Symptoms the disease was determined [DOI] 10.1021/acs.analchem.0c04952 PMC 바로가기 [Article Type] Article
Micronized / ultramicronized palmitoylethanolamide (PEA) as natural neuroprotector against COVID-19 inflammationArticle Published on 2021-02-232023-06-16 Journal: Prostaglandins & other lipid mediators [Category] MERS, SARS, [키워드] Antiphospholipid syndrome Coronavirus disease 2019 (COVID-19) Neuroinflammation Palmitoylethanolamide (PEA) Phospholipids severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [DOI] 10.1016/j.prostaglandins.2021.106540 PMC 바로가기 [Article Type] Article
Cholesterol, inflammation, and phospholipids: COVID-19 share traits with cardiovascular disease콜레스테롤, 염증 및 인지질: COVID-19는 심혈관 질환과 특성을 공유합니다Article Published on 2021-01-012022-09-11 Journal: Biochimica et biophysica acta. Molecular and cell [Category] MERS, SARS, 바이오마커, [키워드] Abstract Antiphospholipid syndrome cardiovascular disease cholesterol COVID-19 fatty Inflammation LDL Lipid Lipid rafts Omega Omega 3 fatty acids Phospholipids S1P. [DOI] 10.1016/j.bbalip.2020.158839 PMC 바로가기 [Article Type] Article
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19COVID-19로 입원한 환자의 혈청 내 전혈성 자가항체Research Article Published on 2020-11-182022-09-10 Journal: Science Translational Medicine [Category] 진단, 치료제, [키워드] accelerated activated neutrophil Activation antibodies antibody antibody level antibody levels antiphospholipid antibodies autoantibodies autoantibody Autoimmune diseases blood vessel blood vessels Case series Casting circulating Coagulation coagulation pathway COVID-19 COVID-19 patient serum Cutoff develop eight ELISA FIBRIN filtration rate fraction glomerular filtration rate glycoprotein healthy individuals high risk Histopathology hyperactivity IgG IgG and IgM IgM in vitro injected injection Lung histopathology Lupus mice Mouse models NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Occlusion pathogenic pathogenic autoantibodies pathogenic autoantibody pathway Patient patients patients hospitalized patients with COVID-19 phenotype phospholipid Phospholipids Platelet platelet counts positive potential therapeutic target potentially life-threatening promoted Protein prothrombin prothrombotic purified respiratory Respiratory disease reveal serum serum sample serum samples severe COVID-19 severe respiratory disease small blood vessel small blood vessels syndrome the disease threshold Thrombophilia thrombosis thrombotic venous Venous thrombosis with COVID-19 [DOI] 10.1126/scitranslmed.abd3876 PMC 바로가기 [Article Type] Research Article
Electrospun Bioactive Wound Dressing Containing Colloidal Dispersions of Birch Bark Dry ExtractArticle Published on 2020-08-142024-09-02 Journal: Pharmaceutics [Category] 대상포진, [키워드] birch bark extract electrospinning Phospholipids PVA Wound dressing [DOI] 10.3390/pharmaceutics12080770 PMC 바로가기 [Article Type] Article
A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein점 돌연변이는 마이크로솜 트리글리세리드 전달 단백질의 지질 전달 활동을 분리합니다Research Article Published on 2020-08-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect ApoB ApoB-containing lipoprotein ApoB-containing lipoproteins Apolipoprotein B Apolipoprotein B-containing lipoprotein Apolipoprotein B-containing lipoproteins assembly B-lp B-lps bind block blood vessels cardiovascular cardiovascular disease circulation complex conserved Critical crystal structure cytoplasmic lipid droplet cytoplasmic lipid droplets disease Disruption drug design dyslipidemia dyslipidemias Embryo endogenous lipid fat malabsorption feasible G863V G863V mttp mutant protein G863V mutant protein glycine growth growth defects growth retardation growth retardation) health condition heterodimeric highlight Human human MTP humans hydrophobic identify inhibitor insect Insects intestinal fat malabsorption L475P Lipid lipid transfer activity lipids Lipoproteins metabolism microsomal triglyceride transfer protein Missense mutation modeling morphology Mtp MTP complex MTP triglyceride transfer activity MTTP mutant mutants Mutation opacity phenotype Phospholipids plasma lipoproteins Point mutation power Prevent Protein reduce reported required residue secretion selective selective inhibition Support synthesis Therapeutic approach These data tissues transfer Transport treat Triglyceride triglycerides valine vertebrates wall yolk yolk opacity yolk syncytial layer YSL zebrafish [DOI] 10.1371/journal.pgen.1008941 PMC 바로가기 [Article Type] Research Article
Pulmonary surfactant lipids inhibit infections with the pandemic H1N1 influenza virus in several animal modelsArticle Published on 2020-02-072023-06-23 Journal: The Journal of Biological Chemistry [Category] 신종인플루엔자, [키워드] antiviral agent host defense Inflammation Influenza Innate immunity phosphatidylglycerol phosphatidylinositol Phospholipids Pulmonary Surfactant treatments Virology [DOI] 10.1074/jbc.RA119.012053 PMC 바로가기
Phosphatidylcholine Biosynthesis in Mitis Group Streptococci via Host Metabolite Scavenging미티스 그룹 스트렙토코쿠스에서 숙주 대사물질 수집을 통한 포스파티딜콜린 생합성Article Published on 2019-09-092024-08-23 Journal: Journal of Bacteriology [Category] 폐렴구균 감염증, [키워드] Phosphatidylcholine Phospholipids Streptococcus pneumoniae [DOI] 10.1128/JB.00495-19 PMC 바로가기
Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine스트레스 반응 및 대사 유전자 조절은 낮은 S-아데노실메티오닌에서 변경됩니다.Research Article Published on 2018-11-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated activating Acute stress affected alcohol analyzed animal animals assays Bacterial Caenorhabditis elegan Caenorhabditis elegans choline chromatin cystic fibrosis deficiencies deficiency disease Disease progression DNA Donor elegan elegans enzyme Enzymes exacerbate expression fibrosis Gene Expression Gene regulation Genes Genetic group Heat shock heat stress histone Histones in some influence less metabolism metabolite methionine methyl groups Methylation Modification modify nucleic acid organism Organisms pathogen Phosphatidylcholine Phospholipids produced Protective provide Reactions reduced Regulation required respond response responses RNA S-adenosylmethionine SAM Stress stress conditions survival tissue injury Transcription transcriptional response transcriptional responses variety [DOI] 10.1371/journal.pgen.1007812 PMC 바로가기 [Article Type] Research Article