Phosphoproteomics – Page 2 – Communicable Diseases Research

PI4-kinase and PfCDPK7 signaling regulate phospholipid biosynthesis in Plasmodium falciparum

Article

Published on 2022-02-032024-08-28
Journal: EMBO Reports [Category] 말라리아,

Evolution of enhanced innate immune evasion by SARS-CoV-2

SARS-CoV-2에 의한 강화된 타고난 면역 회피의 진화

Article

Published on 2021-12-232022-09-10
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료법,

[키워드] Activation adaptation airway airway epithelial cell airway epithelial cells Alpha Alpha variant antagonists assays association B.1.1.7 changes in characterization coding region contribute Delta Duration of infection effective effort ENhance epithelial cells expression first-wave Human human-to-human transmission immune responses increase increase in innate immune innate immune response innate immune responses Interaction isolate isolates lead likelihood MAVS mitochondrial Mutation nucleocapsid protein observation omicron ORF6 Orf9b Phosphoproteomics Phosphorylation Protein protein level protein levels Proteins proteomics regulated regulatory region Replication required RNA RNA sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein suppress suppresse suppressed Systems biology the spike protein Transmission upregulation variant variants variants of concern Viral viral adaptation viral replication
[DOI] 10.1038/s41586-021-04352-y PMC 바로가기 [Article Type] Article

Targeting CK2 mediated signaling to impair/tackle SARS-CoV-2 infection: a computational biology approach

SARS-CoV-2 감염을 손상/퇴치하기 위한 CK2 매개 신호 표적화: 컴퓨터 생물학 접근

Research Article

Published on 2021-12-202022-09-10
Journal: Molecular Medicine [Category] SARS, 신약개발, 유전자 메커니즘,

[키워드] Analysis antagonist antagonistic effect anticancer antiviral activity antiviral responses approach attenuation bind bleeding Cancer cancer treatment Cell CIGB-300 CK2 inhibitor Coagulation Combination computational analysis Computational biology coronavirus drug Drug repurposing early stage early stages Evidence evidence of Functional enrichment analyses Functional enrichment analysis HSBP1 human cells immune response incidence infected with SARS-CoV-2 inhibitor interfere Interference life cycle mechanism molecular molecular mechanism muscle NPM1/B23 peptide phenotype Phenotypes Phosphoproteomics Phosphorylation predict predicted provide provided recent respiratory respiratory disorders responsible Result RNA splicing SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle Signaling SQSTM1 SRSF1 supplementary material Support targeting the SARS-CoV-2 treat Viral viral infection viral infections virus Virus-host interaction Virus-host interactions was used
[DOI] 10.1186/s10020-021-00424-x PMC 바로가기 [Article Type] Research Article

Proteomic Signature of Host Response to SARS-CoV-2 Infection in the Nasopharynx

비인두에서 SARS-CoV-2 감염에 대한 숙주 반응의 단백질 서명

Research

Published on 2021-08-142022-09-10
Journal: Molecular & Cellular Proteomics : MCP [Category] 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition AGC, automatic gain control airway AKT Analysis antiviral property antiviral signaling asymptomatic infection caused CEP131 CFAP57 characterized ciliary component components confirmed COVID-19 case controls coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 severity COVID-19, Coronavirus disease 2019 CXCL10 downregulation dysregulated immune response dysregulation E3 ubiquitin ligases FDR, false discovery rate Health High-resolution host response humans IFN, interferon immune response implicated infected individual infected individuals Infection Inflammatory response interferon interferon-stimulated gene interferon-stimulated genes investigator investigators involved ISG15 ISGs, interferon-stimulated genes mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular MPB, mobile phase B multiorgan disease MX1 nasopharyngeal swabs negative control negative controls NHBE, normal human bronchial epithelial novel NP, nasopharyngeal OGFR, opioid growth factor receptor OPRPN, Opiorphin prepropeptide pandemic Pathogenesis pathogenesis of COVID-19 Pathways performed phosphoproteome Phosphoproteomics Phosphorylation PKC PPIase, peptidyl-prolyl cis/trans isomerase PRM, parallel reaction monitoring proteasomal Protein protein synthesis proteomic Proteomic analysis proteomics PRRs, pathogen-recognition receptors respiratory response RIG-I SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown signaling pathway signature Stat1 subunits Swab These data upper airway upregulated upregulation valuable resource Viral viral entry viral infection viral infections virus
[DOI] 10.1016/j.mcpro.2021.100134 PMC 바로가기 [Article Type] Research

SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

SARS-CoV-2는 인간 췌장 β 세포를 감염시키고 β 세포 손상을 유발합니다

Article

Published on 2021-08-032022-09-11
Journal: Cell Metabolism [Category] SARS, 바이오마커,

[키워드] ACE2 Apoptosis apoptotic attenuate beta cell Cell Cell signaling cells coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity demonstrated diabete diabetes elicit Evidence expressed expression Factor impairment in vitro indicate induce infect insulin islet killing neuropilin neuropilin 1 NRP1 pancreatic pancreatic beta cell pandemic Pathway analysis Patient Phosphoproteomics receptor rescued SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike SARS-CoV-2 spike protein secretion severe COVID-19 Signaling Spike protein T1D tested the SARS-CoV-2 TMPRSS2 Type 1 diabetes while
[DOI] 10.1016/j.cmet.2021.05.013 PMC 바로가기 [Article Type] Article

Kinetic Multi-omic Analysis of Responses to SARS-CoV-2 Infection in a Model of Severe COVID-19

중증 COVID-19 모델에서 SARS-CoV-2 감염에 대한 반응의 동역학적 다중 오믹 분석

Pathogenesis and Immunity

Published on 2021-07-282022-09-10
Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] absence active viral infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar animal model animal models approach caused changes in chemokines coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 develop disease effort evaluated Extrapulmonary gene transcription hamster heart host response host responses human disease human isolates of SARS-CoV-2 immune in vivo increase in Infection innate immune response interferon interferon-stimulated gene isolate kidney kidneys kinetic kinetic analysis lack Model Monocytes Multiorgan neutrophil pandemic Pathogenesis pathology peaked phosphoproteome Phosphoproteomics Pneumonia protein expression proteome proteomics pulmonary disease respiratory response RNA-Seq SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 severe SARS severe SARS-CoV-2 These data to define Transcription Transcriptome transcriptome changes type I Viral viral infection
[DOI] 10.1128/JVI.01010-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity

KEA3: improved kinase enrichment analysis via data integration

AcademicSubjects/SCI00010

Published on 2021-07-022022-10-31
Journal: Nucleic Acids Research [Category] COVID-19, SARS,

[키워드] cellular co-expression co-occurrence collected database enrichment enrichment analysis examined expected experiment experiments Gene Expression IMPROVE Interaction kinase Phosphoproteomics phosphorylated predict predicted Proteins proteomics responsible Signaling Small molecules substrate supported upstream
[DOI] 10.1093/nar/gkab359 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010

Proteomics: A Tool to Study Platelet Function

Review

Published on 2021-04-302023-06-12
Journal: International Journal of Molecular Sciences [Category] MERS,

[키워드] LC-MS/MS mass spectrometry Phosphoproteomics platelet transfusion proteomics Platelets precision medicine PTMs Signaling targeted proteomics
[DOI] 10.3390/ijms22094776 PMC 바로가기 [Article Type] Review

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

Article

Published on 2020-11-192023-06-15
Journal: Molecular Cell [Category] MERS, SARS,

[키워드] antivirals COVID-19 Infection mass spectrometry Pathogenesis Pathways Phosphoproteomics Pneumocytes SARS-CoV-2 time course
[DOI] 10.1016/j.molcel.2020.11.028 PMC 바로가기

Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication

Article

Published on 2020-08-112023-07-02
Journal: Molecular Cell [Category] SARS,

[키워드] COVID-19 Drug repurposing Phosphoproteomics PI3K proteomics RAS SARS-CoV-2 Signaling TMT viral replication
[DOI] 10.1016/j.molcel.2020.08.006 PMC 바로가기