Protein post-translational modification in SARS-CoV-2 and host interactionReview Published on 2023-01-132024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] acylation ADP-ribosylation glycosylation Methylation Phosphorylation SARS-CoV-2 ubiquitination [DOI] 10.3389/fimmu.2022.1068449 PMC 바로가기 [Article Type] Review
The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosisarticle Published on 2023-01-072024-09-05 Journal: Journal of Biomedical Science [Category] update2024, [키워드] HSP27 miRNA Phosphorylation Protein degradation pulmonary fibrosis Smurf2 [DOI] 10.1186/s12929-023-00896-5 PMC 바로가기 [Article Type] article
Glycogen Synthase Kinase-3 Interaction Domain Enhances Phosphorylation of SARS-CoV-2 Nucleocapsid ProteinArticle Published on 2022-12-312023-07-11 Journal: Molecules and cells [Category] COVID19(2023년), [키워드] Axin delta and omicron variants Glycogen synthase kinase-3 nucleocapsid Phosphorylation severe acute respiratory syndrome coronavirus 2 [DOI] 10.14348/molcells.2022.0130 PMC 바로가기
Open Modification Searching of SARS-CoV-2-Human Protein Interaction Data Reveals Novel Viral Modification SitesArticle Published on 2022-12-012023-07-10 Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), [키워드] open modification searching Phosphorylation post-translational modification protein–protein interactions S-nitrosylation SARS-CoV-2 ubiquitination [DOI] 10.1016/j.mcpro.2022.100425 PMC 바로가기
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylationArticle Published on 2022-11-012023-07-10 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), [키워드] N protein nucleocapsid Nucleosome Phosphorylation plus-stranded RNA virus. RNA binding protein RNA virus SARS-CoV-2 [DOI] 10.1016/j.jbc.2022.102560 PMC 바로가기
Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activationArticle Published on 2022-11-012022-11-15 Journal: Veterinary microbiology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] abrogated activated activating Activation acute respiratory syndrome Alpha antiviral immunity AP-1 binding C-terminal domain caused chemokine coronavirus coronavirus disease COVID-19 Cytokine release syndrome deleting demonstrated dependent on domain E E protein expression facilitate help IL-6 IL-8 induce Infection Inflammation inhibitor interleukin-6 IκBα life-threatening Local molecular mechanism motif NF-κB NF-κB pathway nuclear nuclear translocation p65 Pathogenesis PDCoV. Phosphorylation Proinflammatory cytokine promoter protein phosphorylation resulting SARS-CoV-2 Severe case upregulated [DOI] 10.1016/j.vetmic.2022.109553 PMC 바로가기
Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2Article Published on 2022-10-162022-11-15 Journal: Communications Biology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activate antivirals Apoptosis blocked Ebola virus Extracellular glycoprotein herpes simplex virus inhibit inhibited kinase Kinase inhibitor outer membrane Phosphorylation plasma membrane promote Protein pseudotyped receptor engagement SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike protein signaling pathway subsequent target translocation triggered triggering unique vesicular stomatitis virus viral entry virus VSV [DOI] 10.1038/s42003-022-04067-4 PMC 바로가기
The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
Distinct evolutionary trajectories of SARS-CoV-2-interacting proteins in bats and primates identify important host determinants of COVID-19박쥐와 영장류에서 SARS-CoV-2 상호작용 단백질의 뚜렷한 진화 궤적은 COVID-19의 중요한 숙주 결정 요인을 식별합니다Article Published on 2022-08-302022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 치료기술, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation adaptive Analysis Arm arms race autophagy bat bats caused clinical trial comparative genetics coronavirus coronavirus disease COVID-19 COVID-19 severity detection determinant Epidemics functional FYCO1 Genes Genetic genetic determinant Genome genomes Host humans identify in vivo Inflammation Inflammatory involved loci mammalian occurred pandemic Pathogenesis performed Phosphorylation positive Positive selection primates primates and bats Protein Regulation Replication residue residues RIPK1 SARS-CoV SARS-CoV-2 SARS-CoV-2 and COVID-19 SARS-COV-2 infection SARS-CoV-2 susceptibility severe acute respiratory syndrome Coronavirus severe COVID-19 severity signature susceptibility targets TMPRSS2 trajectory Vaccines virus virus–host coevolution. [DOI] 10.1073/pnas.2206610119 PMC 바로가기 [Article Type] Article
Roles and functions of SARS-CoV-2 proteins in host immune evasion숙주 면역 회피에서 SARS-CoV-2 단백질의 역할과 기능Review Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] accessory protein accessory proteins activator acute respiratory syndrome acute respiratory syndrome coronavirus coronavirus described ENCODE evade Frame function functions Genome Host host immune system IFN-β IFNs immune immune evasion inhibiting interferon interferons IRF3 mechanism mechanisms NF-κB nine non-structural protein non-structural proteins nsp1 Nsp12 nsp13 nsp14 Nsp15 nsp5 NSP6 NSP8 Nsps nuclear nuclear translocation Open reading frame ORF10 ORF3b ORF6 ORF8 Orf9b Perspective Phosphorylation Protein Regulatory role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT2 STATs structural proteins suppress TBK1 Transcription type I type I and III interferons variety Viral protein Viral proteins [DOI] 10.3389/fimmu.2022.940756 PMC 바로가기 [Article Type] Review