Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2약물-유도인지 지질증은 SARS-CoV-2에 대한 약물 용도를 혼란스럽게한다Article Published on 2021-10-032022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 신약개발, 치료기술, 치료제, [키워드] active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amiodarone Antiviral antiviral activity antiviral efficacy Azithromycin cationic caused clinical trials coronavirus correlated drug Drug discovery drug-induced Early detection focus Hydroxychloroquine induce Ligand mechanism molecules Phospholipidosis Physicochemical properties physicochemical property receptor Repurposed drugs repurposing respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus target tested the disease therapeutic potential treatments for COVID-19 [DOI] 10.1126/science.abi4708 PMC 바로가기 [Article Type] Article
Cyanobacterial metabolites as promising drug leads against the M pro and PL pro of SARS-CoV-2: an in silico analysis유망한 약물로서 시아 노 박테리아 대사 산물은 SARS-COV-2의 M Pro 및 PL PRO에 대한 이끌어 낸다 : AN Silico AnalysisArticle Published on 2021-10-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antiviral drug antiviral drugs approach binding energy binding pocket carrageenan causative agent Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryptophycin cyanobacterial metabolites cylindrospermopsin deoxycylindrospermopsin drug-likeness effective effort exhibited facilitate followed by foundation in silico in silico analysis in vitro in vivo inhibitor inhibitory lack M pro metabolite metabolites MM-PBSA molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations pandemic Papain Papain-like protease Pathologies Physicochemical properties physicochemical property polyprotein present protease Proteases Research research finding respiratory robust SARS-CoV-2 SARS-CoV-2 protease the SARS-CoV-2 Toxicity Treatment Viral viral replication were assessed [DOI] 10.1080/07391102.2020.1794972 PMC 바로가기 [Article Type] Article
An in-depth in silico and immunoinformatics approach for designing a potential multi-epitope construct for the effective development of vaccine to combat against SARS-CoV-2 encompassing variants of concern and interest우려 및 관심의 변이를 포함하는 SARS-CoV-2에 대항하는 백신의 효과적인 개발을 위한 잠재적인 다중 에피토프 구성을 설계하기 위한 심층 실리코 및 면역정보학 접근 방식Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Antibody titer antigenicity approach B cell B cell epitope B-cell epitope B.1.1.7 B.1.351 B.1.427 B.1.429 B.1.526 B.1.617.1 B.1.617.2 binding Cell cells coronavirus COVID-19 effective elevated epitope Health immune response Immunity immunoinformatics in silico in vitro linker linkers MEV Multi-epitope vaccine NK cells nucleotide nucleotide sequence ORF1 ORF10 ORF1ab ORF3a ORF6 ORF7a ORF7b ORF8 outbreak P.1 P.2 Pathogens Physicochemical properties polyprotein present Prevent preventive measure receptor S protein SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell epitope T-cell the vaccine TLR2 TLR4 Toll-like receptor Toll-like receptors turn utility Vaccine vaccine construct variants variants of concern variants of interest variants of SARS-CoV-2 viral pathogen were used [DOI] 10.1016/j.compbiomed.2021.104703 PMC 바로가기 [Article Type] Article
Airborne transmission of respiratory viruses호흡기 바이러스의 공중 전염Review Published on 2021-08-272022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘, [키워드] activities acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance aerosol aerosol transmission Aerosols affected affecting airflow alveolar breathing can not CDC center characterized Contact contact with contaminated surface contaminated surfaces contribute Control coronavirus cough coughing coughs COVID-19 COVID-19 pandemic CREDIT Critical defined description disease control Diseases distance dominant droplet droplets emitter enrichment environmental factors Evidence exhale experiments expiratory exposure to Factor filtration fomite fraction Frequency Health Organization Height Host hosts Human rhinovirus Improved increasingly individual infected individual infected individuals infecting Infection infectious infectious viruses Influenza Influenza virus inhalation Inhaled Intervention involved knowledge lack less limitation Lungs majority Mask Masks measure Measures mechanism MERS Middle East Middle East respiratory syndrome mitigate new infection new infections occur other respiratory virus Other respiratory viruses Outbreaks pandemic pathogen Pathogens pathway penetrate phase Physicochemical properties physicochemical property prevalent prevention produced provided Radiation reduce relative contribution relative contributions Relative humidity respiratory respiratory aerosols respiratory droplet Respiratory droplets respiratory infections respiratory pathogen Respiratory pathogens respiratory syncytial virus respiratory tract respiratory virus respiratory viruses review rhinovirus robust RSV SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shown sneeze sneezes Spread superspreading event syndrome temperature thought through contact Transmission transmission of SARS-CoV-2 transmission pathway transmission pathways transmitted Transport transported Travel ultraviolet Ultraviolet radiation upper airway velocity Ventilation virus viruses WHO World Health Organization [DOI] 10.1126/science.abd9149 PMC 바로가기 [Article Type] Review
Similarities and differences in the conformational stability and reversibility of ORF8, an accessory protein of SARS-CoV-2, and its L84S variantSARS-CoV-2의 보조 단백질인 ORF8과 그 L84S 변이체의 구조적 안정성과 가역성의 유사점과 차이점Article Published on 2021-07-232022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 진단, [키워드] acidic conditions acidic pH acute respiratory syndrome acute respiratory syndrome coronavirus analyzed cause Cell characteristic conformational coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 examined exhibited finding functional greater indicated L84S variant less Neutral nuclear nuclear magnetic resonance ORF8 ORF8 protein Physicochemical properties physicochemical property precipitated produced Protein Protein conformation protein stability purified respiratory reversed Reversibility room temperature SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stability strain Structure suggested temperature Tobacco variant variants was used wild-type Δ382 [DOI] 10.1016/j.bbrc.2021.05.074 PMC 바로가기 [Article Type] Article
In-silico screening for identification of potential inhibitors against SARS-CoV-2 transmembrane serine protease 2 (TMPRSS2)SARS-CoV-2 막횡단 세린 프로테아제 2(TMPRSS2)에 대한 잠재적 억제제 식별을 위한 인실리코 스크리닝Article Published on 2021-07-012022-09-11 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding energy binding free energy bridge calculated calculation China complex Compound condition coronavirus COVID COVID-19 docking downloaded drug drug repositioning eight Emergency form free energy highest homology human cell hydrogen Hydrogen bond hydrophobic hydrophobic interactions infected patients inhibitor Interaction Mechanics Medicine Medicines MM/PBSA molecular docking Molecular mechanics pandemic performed Physicochemical properties Protein protein structure protein-ligand reducing Research residues respiratory infection responsible salt Salt Bridge SARS-CoV-2 SARS-CoV-2 virus screened Serine serine protease Spread stability the SARS-CoV-2 virus TMPRSS2 TMPRSS2 protein transmembrane region transmembrane serine protease transmembrane serine protease 2 Transmissibility viral entry Virtual screening virus were used Wuhan Zinc ZINC database [DOI] 10.1016/j.ejps.2021.105820 PMC 바로가기 [Article Type] Article
A unique view of SARS-CoV-2 through the lens of ORF8 proteinORF8 단백질 렌즈를 통한 SARS-CoV-2의 독특한 시각Article Published on 2021-06-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive amalgamation Amino acid Analysis antiviral response bat Characteristics Chemical coronavirus down-regulation Effect highlight histocompatibility Host host immunity hosts immune immune evasion immune responses innate immune response innate immune responses interferon Major major histocompatibility complex modulate Mutation Mutational hotspots ORF8 ORF8 evolution ORF8 protein ORF8 proteins pangolin pangolin-CoV performed Perspective phylogenetics phylogenies Physicochemical properties predicted Protein sample collection SARS-CoV-2 sequence similarity severe acute respiratory syndrome Coronavirus structural property unique variant [DOI] 10.1016/j.compbiomed.2021.104380 PMC 바로가기 [Article Type] Article
β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19Pharmacology Published on 2021-05-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activate activating Activation acute respiratory syndrome adhesion molecules Affect affected Anti-inflammatory anti-inflammatory property Antiviral beta-caryophyllene Bioavailability candidate candidate drug cannabinoid cascade caused chemokines Clinical studies Complication coronavirus COVID-19 Cytokines dietary disease Eicosanoids functional G-protein identifying immune modulation Immunity immunomodulator immunomodulators immunomodulatory properties Infection Inflammation Inflammatory mediators inhibit investigated Ligand modulate modulating modulation molecular mechanisms natural natural products Nuclear receptors pandemic Pathogenesis pharmacokinetic pharmacological pharmacological mechanism Physicochemical properties plants preventive measures Protective public health emergency receptor receptors response SARS-CoV-2 selective signaling pathway signaling pathways target therapeutic therapeutic effect therapeutic potential therapeutic strategy therapeutic target tissue Toxicity Treatment Trinity unique [DOI] 10.3389/fphar.2021.590201 PMC 바로가기 [Article Type] Pharmacology
In Silico Studies of Some Isoflavonoids as Potential Candidates against COVID-19 Targeting Human ACE2 (hACE2) and Viral Main Protease (M pro )Article Published on 2021-05-102022-10-30 Journal: Molecules [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affinity Anti-SARS-CoV-2 Activity antiviral activity binding energy binding mode candidate carried caused China co-crystallized Compound coronavirus COVID-19 disease docking result drug-likeness examined hACE2 Human human ACE2 in silico Interaction Isoflavonoid isoflavonoids Ligand M pro main protease molecular docking Molecular docking study pandemic Physicochemical properties Potential reported SARS-CoV-2 specific treatment targeting Toxicity unique WHO widespread [DOI] 10.3390/molecules26092806 PMC 바로가기 [Article Type] Article
Immunoinformatics Identification of B- and T-Cell Epitopes in the RNA-Dependent RNA Polymerase of SARS-CoV-2Research Article Published on 2021-04-202022-10-31 Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19, [키워드] acute respiratory syndrome allele Antigen antigenicity B-cell beta coronavirus Candidates contagious Coronavirus-2 COVID-19 COVID-19 cases drug epitope Epitopes evaluated highly antigenic HLA identification immune Interaction leukocyte non-allergenic non-toxic pandemic disease peptide Physicochemical properties predicted Predictive Protein public health emergency RdRP RdRp protein RNA RNA-dependent RNA polymerase SARS-CoV-2 specificity stability T-cell T-cell epitope Toxicity Vaccine virus World Health Organization [DOI] 10.1155/2021/6627141 PMC 바로가기 [Article Type] Research Article