point mutations – Page 2 – Communicable Diseases Research

David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors

데이비드 대 골리앗: 잠재적인 SARS-CoV-2 억제제로서의 ACE2-Fc 수용체 트랩

Review

Published on 2022-01-012022-09-11
Journal: mAbs [Category] SARS, 변종,

Drug Sensitivity Profile of Fungi Isolated from Onychomycosis Patients and Evaluation of Squalene Epoxidase Mutation in One Terbinafine-Resistant Trichophyton mentagrophytes Species

Article

Published on 2021-12-312024-08-31
Journal: Microbial Drug Resistance [Category] 백선증,

[키워드] dermatophytes Molds Onychomycosis point mutations resistance terbinafine yeast
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Single-Point Mutations in the N Gene of SARS-CoV-2 Adversely Impact Detection by a Commercial Dual Target Diagnostic Assay

SARS-CoV-2의 N 유전자에 있는 단일점 돌연변이는 상업용 이중 표적 진단 분석에 의한 역효과 검출

Research Article

Published on 2021-11-172022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection amplicons amplification amplified assays binding Cepheid Cepheid Xpert coronavirus Critical detection determine Diagnosis diagnostic diagnostic assay diagnostic tests early diagnosis eight FIVE gene target Genetic genomic gold gold standard highlight Impact knowledge Mutation N gene nucleic acid amplification tests occur pandemic patients PCR product point mutations position Rapid diagnostic test Real-time PCR Region reported respiratory responsible SARS-CoV-2 SARS-CoV-2 genome sequenced Sequencing severe acute respiratory syndrome Coronavirus single-point mutation single-point mutations target the SARS-CoV-2 genome whole genome whole genomes
[DOI] 10.1128/Spectrum.01494-21 PMC 바로가기 [Article Type] Research Article

FnCas9-based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV-2 variants on a paper strip

종이 스트립에서 주요 SARS-CoV-2 변종을 빠르고 정확하게 감지하기 위한 FnCas9 기반 CRISPR 진단

Tools and Resources

Published on 2021-06-092022-09-10
Journal: eLife [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제,

[키워드] a band affected antibodies antibody Antigen approach band bind binding can be used can not Cas9 change changes in chemical reaction China comorbid conditions Council country COVID-19 COVID-19 pandemic CRISPR CRISPRDx deep sequencing detect determine diagnose Diagnosis diagnostic diagnostics Disease surveillance DNA E484K Efficacy Elderly patient elderly patients eLife faster FELUDA finding FnCas9 form fraction Francisella Genome global health gold gold standard Health health authorities high viral load highlighting hour identify impacted increased mortality India individual Industrial Lateral lateral flow Lateral flow test Lateral flow tests less Lineage MONITOR MOST mutant Mutant SARS-CoV-2 mutant virus mutant viruses mutate mutated Mutation mutations N501Y NGS nucleic acid nucleic acid sequence nucleic acids offer overcome passage Patient Point mutation point mutations populations positive result positive sample Pregnancy pregnancy tests prognostic Protein Protein binding public health authorities public health authority qRT-PCR quantitative real-time PCR responsible RNA S gene SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test SARS-CoV-2 variant SARS-CoV-2 virus sensitivity sequence Sequencing shown signal specific protein specificity Spread strain Strains strip T716I target technique the disease the SARS-CoV-2 virus theory time-consuming turn Vaccine vaccine efficacy variant variants Viral Viral load virus viruses widespread wild-type Wuhan
[DOI] 10.7554/eLife.67130 PMC 바로가기 [Article Type] Tools and Resources

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses

MHC-I 제한 에피토프의 SARS-CoV-2 돌연변이는 CD8 + T 세포 반응을 회피합니다

Research Articles

Published on 2021-03-042022-09-10
Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단,

Genomic mutations and changes in protein secondary structure and solvent accessibility of SARS-CoV-2 (COVID-19 virus)

SARS-CoV-2(COVID-19 바이러스)의 게놈 돌연변이 및 단백질 2차 구조 및 용매 접근성의 변화

Article

Published on 2021-02-102022-09-10
Journal: Scientific Reports [Category] MERS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis caused changes changes in coding gene coding genes coding region coding regions coronavirus COVID-19 pandemic COVID-19 virus D614G Data mining dataset deep learning Evolution facilitate genomic genomic mutation genomic mutations highly pathogenic Intervention Mutation mutation D614G ORF10 ORF6 ORF7a ORF7b pandemic Point mutation point mutations predicted prediction Protein researchers respiratory respond SARS-CoV-2 secondary structure severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 solvent Spike protein Spread tracing Transmission unlikely Vaccine Viral viral genome sequences virus virus spike protein
[DOI] 10.1038/s41598-021-83105-3 PMC 바로가기 [Article Type] Article

Multicomplex-based pharmacophore modeling in conjunction with multi-target docking and molecular dynamics simulations for the identification of Pf DHFR inhibitors

Article

Published on 2019-10-312024-09-09
Journal: J Biomol Struct Dyn [Category] 말라리아,

[키워드] molecular dynamics simulations multi-target docking multicomplex-based pharmacophore. point mutations
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The nucleoid occlusion protein SlmA is a direct transcriptional activator of chitobiose utilization in Vibrio cholerae

nucleoid occlusion protein SlmA는 Vibrio cholerae에서 키토비오스 활용의 직접적인 전사 활성제입니다.

Research Article

Published on 2017-07-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation activity addition aquatic environment bind Catabolism cause Cell cell division ChiS chitin chitobiose cholera cholerae composed Critical disaccharide disease disparate disrupt downstream drinking water Evolution expression function Gene regulation gene transfer horizontal gene Horizontal gene transfer identify implicated in vivo Interaction involved locus mechanism member mutant pathogen persistence Point mutation point mutations promoter Protein Proteins regulated Regulation regulator required TetR the marine transcriptional transcriptional activation transcriptional regulator transfer transposon utilization Vibrio cholerae water
[DOI] 10.1371/journal.pgen.1006877 PMC 바로가기 [Article Type] Research Article