Three-Dimensional Structural Stability and Local Electrostatic Potential at Point Mutations in Spike Protein of SARS-CoV-2 CoronavirusArticle Published on 2024-02-112024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] ACE2 receptor contagiousness coronavirus variants folding energy isoelectric point point mutations protein electrostatics S-protein SARS-CoV-2 surface electric potential [DOI] 10.3390/ijms25042174 PMC 바로가기 [Article Type] Article
Genomic surveillance, evolution and global transmission of SARS-CoV-2 during 2019-20222019-2022년 동안 SARS-CoV-2의 게놈 감시, 진화 및 전 세계 전파Article Published on 2022-08-012022-09-11 Journal: PLoS ONE [Category] SARS, 변종, 유전자 메커니즘, [키워드] analyzed Beta conducted correlation COVID-19 pandemic Delta died E484K Evolution Evolutionary rate fatality followed by Frequency Gamma genomic genomic data Genomic surveillance growth growth rate Health help information L452R likelihood Multiple Multiple sequence alignment Mutation N439K N501Y omicron outcome pandemic Point mutation point mutations predominant prevalent reduce SARS-COV-2 infection sequence Sequence alignment Spike protein Substitution Surveillance transmission of SARS-CoV-2 Vaccine variant variants VoC [DOI] 10.1371/journal.pone.0271074 PMC 바로가기 [Article Type] Article
Presumptive positive with the Cepheid Xpert Xpress SARS-CoV-2 assay due to N mutations in the Delta variantDelta 변이체의 N 돌연변이로 인한 Cepheid Xpert Xpress SARS-CoV-2 분석에서 추정 양성Article Published on 2022-07-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] 2019-nCoV authorization C29200T C29203T Cepheid Cepheid Xpert® Xpress SARS-CoV-2 assay Chain Reaction Delta delta variant Delta variants drug Emergency Emergency use authorization false False negative FDA food indicated Mutation N gene N mutation PCR assay platform Point mutation point mutations polymerase chain polymerase chain reaction positive presumptive positive. real time PCR real-time RT-PCR reported reverse transcription RT-PCR RT-PCR assay SARS-CoV-2 SARS-CoV-2 detection the United State United States United States Food and Drug Administration US CDC variants Whole genome sequencing [DOI] 10.1016/j.diagmicrobio.2022.115699 PMC 바로가기 [Article Type] Article
Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13SARS-CoV, SARS-CoV-2 및 박쥐 코로나바이러스 RaTG13의 게놈 간의 삽입 및 삭제 돌연변이Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 base bases bat bat coronavirus RaTG13 Complete coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) developmental distribution FIVE Frame gene sequence Genome genome sequence Genome sequences genomes Inconclusive INDEL indels insertion insertion-and-deletion mutation mechanism MOST Mutation mutation rate mutations Noncoding region nonstructural protein 3 Open reading frame ORF ORF8 ORF8 gene ORF8 genes Point mutation point mutations protein 3 RaTG13 replaced REPLACED BY replacement S1 domain SARS-CoV SARS-CoV-2 SARS-CoV-2 genome sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus (SARS-CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein the SARS-CoV-2 genome the spike protein viral genome virus [DOI] 10.1128/spectrum.00716-22 PMC 바로가기 [Article Type] Article
How Do Point Mutations Enhancing the Basic Character of the RBDs of SARS-CoV-2 Variants Affect Their Transmissibility and Infectivity Capacities?SARS-CoV-2 변종 RBD의 기본 특성을 향상시키는 점 돌연변이가 전염성과 감염력에 어떤 영향을 미칩니까?Review Published on 2022-04-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor ACE2 receptors arginine arginine residue arginine residues basic binding affinity cell receptors character charged residues contribute coronavirus coulombic charges COVID-19 creating delta variant difference Effect electrostatic Enhancing glutamic acid host cells increase in Infectivity lysine Mu variant mutations Omicron variant Point Point mutation point mutations RBD RBD-ACE2 Recognition residue Salt Bridge SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spike protein RBD Spike proteins Spread spreading capacity surface electrostatic potential the RBD the SARS-CoV-2 the spike protein Transmissibility variants [DOI] 10.3390/v14040783 PMC 바로가기 [Article Type] Review
Is Omicron the last SARS-CoV-2 Variant of Concern?Omicron은 마지막 SARS-CoV-2 변종 우려 대상입니까?Article Published on 2022-04-012022-09-11 Journal: Archives of medical research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Betacoronavirus country COVID-19 pandemic Delta delta variant development died herd immunity highest Hospitalization hygiene Immunity implementation Local mutations omicron Omicron variant outbreak pandemic Point mutation point mutations SARS-CoV-2 SARS-CoV-2 variant sequence sequences South South Africa thought Vaccinations Vaccine variant variant of concern variants [DOI] 10.1016/j.arcmed.2022.01.001 PMC 바로가기 [Article Type] Article
Amplification-free detection of SARS-CoV-2 using gold nanotriangles functionalized with oligonucleotides올리고뉴클레오티드로 기능화된 금 나노삼각형을 사용한 SARS-CoV-2의 증폭 없는 검출Article Published on 2022-04-012022-09-11 Journal: Mikrochimica Acta [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition Alpha amplification Amplification-Free Detection AuNTs Azure Beta biosensor characterized COVID-19 patient COVID-19 patients Delta detect Detection limit develop DNA equipment Gamma gold gold standard growth infective Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples non-infected oligonucleotide omicron Patient platform Point mutation point mutations probe Result RNA sequence RNA sequences RT-qPCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant Viral load [DOI] 10.1007/s00604-022-05272-y PMC 바로가기 [Article Type] Article
Infection clusters can elevate risk of diagnostic target failure for detection of SARS-CoV-2감염 클러스터는 SARS-COV-2의 검출을위한 진단 목표 실패의 위험을 높일 수 있습니다.Research Article Published on 2022-02-162022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] authorization Cepheid clinical laboratories Cluster diagnostic Emergency EUA Frame increase in Infection information Local Mutation N-gene organism Phylogenetic analysis Point mutation point mutations Prevalence risk SARS-CoV-2 Sequencing test results Time frame Variation [DOI] 10.1371/journal.pone.0264008 PMC 바로가기 [Article Type] Research Article
The Remarkable Evolutionary Plasticity of Coronaviruses by Mutation and Recombination: Insights for the COVID-19 Pandemic and the Future Evolutionary Paths of SARS-CoV-2돌연변이 및 재조합에 의한 코로나 바이러스의 현저한 진화 가소성 : Covid-19 Pandemic과 SARS-Cov-2의 미래 진화 경로에 대한 통찰력Review Published on 2022-01-022022-09-10 Journal: Viruses [Category] SARS, 변종, 신약개발, 치료제, [키워드] addition Affect B.1.1.529 birds coronavirus CoV CoV protein CoV proteins COVID-19 COVID-19 pandemic CoVs deletions Epidemics Evolution FIVE focus Future Health highlight homologous Human insertions insight mammal molecular molecular evolution mutations non-homologous omicron pandemic path point mutations positive-sense single-stranded RNA positive-sense single-stranded RNA viruses Recombination recombination event SARS-CoV-2 SARS-CoV-2 pandemic spike strain Transmissibility Vaccine Vaccines viruses zoonotic origin [DOI] 10.3390/v14010078 PMC 바로가기 [Article Type] Review
Enhanced High Mutation Rate and Natural Selection to Produce Attenuated Viral Vaccine with CRISPR Toolkit in RNA Viruses especially SARS-CoV-2RNA 바이러스, 특히 SARS-CoV-2에서 CRISPR 툴킷을 사용하여 약독화 바이러스 백신을 생산하기 위한 향상된 높은 돌연변이율 및 자연 선택Article Published on 2022-01-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] accelerate Attenuated vaccines Cell change changes in coculture condition CRISPR CRISPR toolkit effective effective vaccine Effective vaccines Efficiency enhanced Genome Live attenuated vaccine Live attenuated vaccines natural natural selection Palindromic Pandemics Point Point mutation point mutations problem Produce Rate RNA RNA virus RNA viruses SARS-CoV-2 Selection speed toolkit [DOI] 10.1016/j.meegid.2021.105188 PMC 바로가기 [Article Type] Article