Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases만성 폐질환 환자에서 BNT162b2 COVID-19 백신 2회 접종 후 손상된 면역학적 결과와 관련된 항체 반응 및 위험 인자Article Published on 2022-07-012022-09-12 Journal: BMJ Open Respiratory Research [Category] MERS, 진단, [키워드] 1:1 1.26 95% CI adjusted antibody concentration Antibody Response aRR association Asthma bronchiectasis Charlson Comorbidity Index chronic pulmonary disease cohort study Comorbidity Control controls copd epidemiology COVID-19 COVID-19 vaccination COVID-19 vaccine defined dose Factor fibrosis first vaccination functional geometric healthcare personnel Humoral response identify immunological immunological responses Immunosuppression immunosuppressive Inclusion increasing age Interaction interstitial Interstitial Fibrosis lowest mRNA neutralising neutralising antibody of BNT162b2 outcome Patient Poisson regression Prednisolone Primary outcome Prospective quartile Receptor binding domain reported Responder response responses risk risk factor secondary outcome tested vaccination [DOI] 10.1136/bmjresp-2022-001268 PMC 바로가기 [Article Type] Article
Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2SARS-CoV-2에 대한 자연 및 하이브리드 면역의 보호 및 약화Article Published on 2022-06-092022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted B.1.617.2 BNT162b2 BNT162b2 vaccine confounding factor confounding factors coronavirus Coronavirus 2019 Course database dose elapsed hybrid Immunity infected with SARS-CoV-2 Infection less Ministry of Health natural natural immunity Poisson regression predominant protection provide provided rates of infection receipt recent Reinfection risk SARS-CoV-2 SARS-COV-2 infection second dose second dose of vaccine severe acute respiratory syndrome Coronavirus shown single dose uninfected vaccination Vaccine variant [DOI] 10.1056/NEJMoa2118946 PMC 바로가기 [Article Type] Article
Characteristics and outcomes of sepsis patients with and without COVID-19Research article Published on 2022-06-012022-10-05 Journal: Journal of infection and public health [Category] 바이오마커, [키워드] Acute kidney injury acute respiratory distress syndrome adjusted adjusted relative risk AKIAcute Kidney Injury Analysis analyzed ARDSacute respiratory distress syndrome BMIbody mass index body mass index C-reactive protein Characteristics CIconfidence interval Clinical characteristics confidence interval Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19coronavirus disease 2019 Critically ill CRPC-reactive protein CRScytokine release syndrome Cytokine release syndrome diagnosed ECMOextracorporeal membrane oxygenation extracorporeal membrane oxygenation facilitate HAIHospital acquired infection High-risk patients Hospital acquired infection ICU admission ICU patient ICUIntensive Care Unit identify IL-6interleukin 6 in-hospital mortality independent risk factor Inhaled nitric oxide iNOInhaled nitric oxide intensive care unit interleukin 6 invasive ventilation Kaplan-Meier estimator lactate dehydrogenase LDHlactate dehydrogenase medical icu Mortality not differ outcome Patient patients PCT PCTProcalcitonin Poisson regression procalcitonin Relative risk renal replacement therapy Result risk factor robust RRRelative risk RRTRenal replacement therapy screened Sepsis sepsis patient sepsis patients septic patient septic patients Septic shock sequential organ failure assessment score Sex significantly significantly higher SOFA score SOFA scoreSequential organ failure assessment score surgical survival treated university were assessed WHOWorld Health Organization World Health Organization [DOI] 10.1016/j.jiph.2022.05.008 [Article Type] Research article
Association of national and regional lockdowns with COVID-19 infection rates in Pune, India Research Published on 2022-06-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI age Assessing compartmental model contributing to COVID-19 COVID-19 disease COVID-19 incidence COVID-19 infection COVID-19 patient COVID-19 patients Effect Epidemic epidemic curve examined First wave group growth India infection rate infection rates interquartile range lockdown male management median age National pandemic Patient Poisson regression positive public health reported SARS-CoV-2 Sex Spread subsequent Surveillance tested the patient with COVID-19 [DOI] 10.1038/s41598-022-14674-0 [Article Type] Research
Introduction and transmission of SARS-CoV-2 lineage B.1.1.7, Alpha variant, in Denmark덴마크에서 SARS-CoV-2 계통 B.1.1.7, 알파 변종 도입 및 전파Article Published on 2022-05-042022-09-11 Journal: Genome Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Alpha variant analyzed applied B.1.1.7 benefit calculated collected contributed COVID-19 Denmark dominant effort Epidemic estimate Genome highlight Including initial Lineage Lineage B.1.1.7 lineages onward transmission Phylogenetic analysis Phylogeny Poisson regression positive representing SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage Self-isolation Sequencing study period Surveillance the SARS-CoV-2 These data Transmissibility transmission of SARS-CoV-2 Travel variants [DOI] 10.1186/s13073-022-01045-7 PMC 바로가기 [Article Type] Article
Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting전국적인 환경에서 BNT162b2 mRNA 코비드-19 백신의 4차 접종Comparative Study Published on 2022-04-132022-09-25 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome age analyzed B.1.1.529 BNT162b2 vaccine booster dose Care clinical variables collaboration coronavirus coronavirus disease country death dose doses driven by effective Effectiveness estimate evaluate evaluated Evidence family Francesca Harvard Medical School Health Hospitalization Infection mRNA of BNT162b2 Older outcome outcomes Poisson regression primary analysis recorded reducing relative Result risk SARS-CoV-2 SARS-COV-2 infection Sensitivity analyses sensitivity analysis setting Sociodemographic symptomatic COVID-19 two group Vaccine vaccine dose variant waning immunity was performed [DOI] 10.1056/NEJMoa2201688 PMC 바로가기 [Article Type] Comparative Study
An Observational Cohort Study on the Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and B.1.1.7 Variant Infection in Healthcare Workers by Antibody and Vaccination Status중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 감염 및 B.1.1.7 항체 및 백신 접종 상태에 따른 의료 종사자의 변이 감염 발생률에 대한 관찰 코호트 연구Observational Study Published on 2022-04-092022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted age anti-spike antibodies anti-spike antibody antibody B.1.1.7 B.1.1.7 variant BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 Chain Reaction changes in confidence interval coronavirus coronavirus 2 detectable dose doses evade Evidence evidence of HCW HCWs healthcare healthcare worker Healthcare workers Immunity incidence incidence rate Infection investigated longitudinal cohort study natural natural immunity natural infection no evidence of Oxford-AstraZeneca pandemic PCR-positive Pfizer-BioNTech Poisson regression polymerase chain polymerase chain reaction provided rate ratio reduced respiratory resulting robust S-gene SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Sequencing seronegative seropositive Seropositivity severe acute respiratory syndrome Coronavirus Sex Single-dose status symptomatic symptomatic and asymptomatic symptomatic infection United Kingdom vaccination Vaccine vaccine dose Vaccine-induced immunity whole genome Whole genome sequencing without symptom worker [DOI] 10.1093/cid/ciab608 PMC 바로가기 [Article Type] Observational Study
A longitudinal study of change in substance use from before to during the COVID-19 pandemic in young adultsResearch article Published on 2022-04-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 유전자 메커니즘, [키워드] age alcohol analyses collected COVID-19 COVID-19 pandemic Factor Frequency funding higher risk incidence longitudinal study MOST pandemic participant Poisson regression Prevalence proportion ranged recruited reported Result risk Schools Society Sociodemographic subgroup Substance use supported young adults [DOI] 10.1016/j.lana.2021.100168 [Article Type] Research article
Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE activity, and COVID-19: A rather controversial hypothesis. A case-control study안지오텐신전환효소 삽입/제거 다형성, ACE 활성, 그리고 코로나19: 다소 논란의 여지가 있는 가설. 사례 대조 연구Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 변종, 유전자 메커니즘, [키워드] ACE ACE activity ACE inhibitor ACE inhibitors ACE polymorphism allele alleles Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme. Angiotensin receptor blockers Angiotensin-converting enzyme arbitrary units carrier case-control study characterized complex conducted Control controls COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient disease severity enzyme epidemiological data expressed First wave Generalized linear model Genotype genotypes healthy individual healthy individuals Hypothesis I/D genotype increased risk individuals insertion insertion/deletion limit mechanism Patient Poisson regression polymorphism Prevalence recruited reduction Renin renin-angiotensin system retrospective risk factor risk ratio risk ratios RRs SARS-CoV-2 severe disease severity shown synergy therapy was used [DOI] 10.1002/jmv.27417 PMC 바로가기 [Article Type] Article
Healthcare Utilization Among Patients Diagnosed with COVID-19 in a Large Integrated Health SystemObservational Study Published on 2022-03-012022-10-04 Journal: Journal of General Internal Medicine [Category] 임상, [키워드] 95% CI average BMI Care cohort study Community Comorbidity conditions COVID-19 COVID-19 diagnosis COVID-related symptoms diagnosed with COVID-19 diagnoses Diagnosis Factor female gender greater health systems healthcare Healthcare system highest Hospitalized hospitalized patient hospitalized patients identify identifying majority Older age pandemic Patient patients performed Poisson regression prevalent quantified resource SARS-CoV-2 smoking Support System utilization was used with COVID-19 [DOI] 10.1007/s11606-021-07139-z PMC 바로가기 [Article Type] Observational Study