Postinfection – Page 2 – Communicable Diseases Research

Expression Profile and Localization of SARS-CoV-2 Nonstructural Replicase Proteins in Infected Cells

Article

Published on 2022-08-312022-11-15
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, 치료법,

Impact of SARS-CoV-2 Omicron on Rapid Antigen Testing Developed for Early-Pandemic SARS-CoV-2 Variants

Article

Published on 2022-08-312022-11-15
Journal: Microbiology Spectrum [Category] SARS, 변종, 치료기술,

A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection

SARS-CoV-2 감염에 대한 항바이러스제의 효능을 평가하기 위한 SCID 마우스 모델

Article

Published on 2022-08-242022-09-11
Journal: Journal of Virology [Category] SARS, 변종, 치료제,

[키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug antiviral drugs antiviral efficacy antivirals B.1.351 B.1.351 variant BALB/c Beta Beta variant binding C57BL/6 CAGE coronavirus Culture drug hamsters Infection infectious virus titer infectious virus titers Infective dose inhibitors intrinsic lack log lung Lung pathology Lungs male mice Model moderate molnupiravir mouse mouse model Mouse models Nirmatrelvir offer Postinfection reagent receptor reduced replicate Replication reported SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain SARS-CoV2 SCID significantly TCID These data tissue tissue culture twice a day Validity variant variants variants of concern Viral load virus virus strain wild-type
[DOI] 10.1128/jvi.00758-22 PMC 바로가기 [Article Type] Article

Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall Response

SARS-CoV-2 감염 및 백신 회수 반응 이후 중간 기억 B 세포의 지속적인 유지

Article

Published on 2022-08-102022-09-12
Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] analyzed antibodies antibody Antigen B cell B cell response booster CD21 CD27 CD4 CD4+ CD4+ T cell Cell correlated COVID-19 demonstrated determine elicited help highlight immune response Immunity immunization individual level infected individual Infection intermediate Kinetics Longevity longitudinal maintain maintenance memory B memory B cell memory B cells neutralization Neutralizing antibodies neutralizing antibody Pandemics persistence persistent phenotype Postinfection Protective Protein recall receptor recovered respond response SARS-CoV-2 SARS-COV-2 infection secreted significantly spike T cells the SARS-CoV-2 triggered vaccination
[DOI] 10.1128/jvi.00760-22 PMC 바로가기 [Article Type] Article

Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages

COVID-19 환자의 비인두 샘플에서 SARS-CoV-2 분석은 다른 계통과 관련하여 우려되는 변이체의 성장 특성을 배치하여 인구 변이 및 다양한 표현형을 보여줍니다

Article

Published on 2022-06-292022-09-11
Journal: mSphere [Category] COVID19(2023년), SARS, 변종,

[키워드] A549 cells Alpha amplified Beta Beta variant Biology biology of SARS-CoV-2 causative agent Cell Cell culture cell line cells change characterized clinical isolates clinical samples concern Context coronavirus COVID-19 Delta disease effective Evolution genetic diversity genetics genome sequence genomic global pandemic growth growth kinetics hACE2 hospitalized patient hospitalized patients humans immune evasion increased risk indicated Infection isolate isolates less Lineage minor minor genomic variants morbidity Mortality Nasopharyngeal swab nasopharyngeal swabs New no difference not different omicron Other other coronaviruses other variant other variants pandemic patients pattern planet Population Population dynamics Population genetics Postinfection preserved property Research RNA RNA sequencing Sample SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence several variants Spread suggested Transmission vaccination Vaccine Variability variant variants variants of concern variants of SARS-CoV-2 Variation Vero E6 Vero E6 cell VERO E6 cells virus Virus evolution VoC VOCs widespread with COVID-19
[DOI] 10.1128/msphere.00913-21 PMC 바로가기 [Article Type] Article

Development and Implementation of Dried Blood Spot-Based COVID-19 Serological Assays for Epidemiologic Studies

역학 연구를 위한 건조혈점 기반 COVID-19 혈청학적 분석의 개발 및 구현

Article

Published on 2022-06-292022-09-11
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] addition alternative ambient ambient temperatures antibodies antibody antibody kinetics antibody levels Antibody Response Antibody responses Bay Blood changes in Cohort Community comparable COVID-19 COVID-19 pandemic Critical DBS sample DBS samples detect development dried blood spot Dried blood spots East Effectiveness enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays estimate estimation Immunity implementation inaccessible Infection Infectious disease Infectious diseases invasive Measures pandemic participant pathogen pathogen-specific phlebotomy Postinfection Prevalence Prevent public health measures Public health responses refrigeration risk factor Risk factors San Francisco SARS-CoV-2 SARS-COV-2 infection serological serological assays serological data serological studies serological surveillance serological survey serology Seroprevalence specific antibodies Spread stability storage study participant Study participants study population Surveillance Traditional vaccination venipuncture venous venous blood
[DOI] 10.1128/spectrum.02471-21 PMC 바로가기 [Article Type] Article

Fcγ-Receptor-Based Enzyme-Linked Immunosorbent Assays for Sensitive, Specific, and Persistent Detection of Anti-SARS-CoV-2 Nucleocapsid Protein IgG Antibodies in Human Sera

인간 혈청에서 항-SARS-CoV-2 뉴클레오캡시드 단백질 IgG 항체의 민감하고, 특이적이고, 지속적인 검출을 위한 Fcγ-수용체 기반 효소 연결 면역흡착 분석법

Article

Published on 2022-06-152022-09-11
Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,

[키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African analytical sensitivity anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody antibody antibody waning Antigen antigen-antibody complexes Asia binding complexes Concentration convalescence convalescent phase coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-reactivity detection diagnostic diagnostic sensitivities dilutions ELISA ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epidemiological studies Epidemiological study Europe FcγR Human IgG IgG antibody Immune complexes immunoassay immunofluorescence immunoglobulins immunological indirect immunofluorescence Infection Infectious disease Laboratory laboratory methods and tools longitudinal samples mandatory morbidity morbidity and mortality mortality rates nucleocapsid protein Pathogens persistent platform Population Postinfection Prevalence prozone receptor Region respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibody sensitive sensitivity serological test Serological tests serum serum sample serum samples severe acute respiratory syndrome Coronavirus significantly significantly higher solution South America Specific Specificities specificity titer Vaccine validation Viral Viral diseases was performed while
[DOI] 10.1128/jcm.00075-22 PMC 바로가기 [Article Type] Article

Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo

대규모 in vitro 스크리닝 및 in vivo 효과 평가를 통한 잠재적 anti-SARS-CoV-2 약물 발굴

Article

Published on 2022-06-012022-09-11
Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 Antiviral antiviral activity antiviral drug approved drug candidate caused Cell culture cisatracurium clinical clinically Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment cytotoxicity D614G D614G variant develop drug Drug repurposing drug resistance Drug screening drugs effective Efficacy Gilteritinib hamster hamster model. hamsters HeLa cell HeLa cells human ACE2 IL-6 in vitro in vivo induce life cycle mRNA pandemic passage Postinfection promoted Prophylactic protective effect provided pulmonary viral reduced Remdesivir Salinomycin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle selected sertraline severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown suppressed the SARS-CoV-2 TNF-α transduced Treatment variety Vero E6 Vero E6 cell VERO E6 cells weight loss
[DOI] 10.1007/s11427-021-2031-7 PMC 바로가기 [Article Type] Article

Post-COVID-19 patients show an increased endothelial progenitor cell production

Research article

Published on 2022-05-012022-10-05
Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 바이오마커,

[키워드] 6-minute walk test 6MWT6-minute walk test abnormal increase ACE-2Angiotensin-Converting Enzyme 2 Admission angiotensin-converting enzyme 2 Arterial hypertension blood circulation BMIbody mass index body mass index C-reactive protein Carbon monoxide diffusing capacity cardiovascular complications Cell clinical parameter colony colony forming cell Control COVID-19 COVID-19 patient CRPC-reactive protein damaged DDDimer-D Diabetes Mellitus Dimer-D DLCOCarbon monoxide diffusing capacity DLPDyslipidemia DMDiabetes mellitus dyslipidemia ECFCEndothelial colony forming cell elevated endothelial Endothelial colony forming cell Endothelial dysfunction Endothelial progenitor cell Endothelium EPCEndothelial progenitor cell EPOerythropoietin erythropoietin evaluate FEVForced expiratory volume FIBFibrinogen fibrinogen forced expiratory volume forced vital capacity FVCForced vital capacity Gender HbHemoglobin healthy controls hematocrit hemoglobin HTAArterial hypertension HTCHematocrit hypertension Injury Isolation lactate dehydrogenase LDHlactate dehydrogenase LymLymphocytes Lymphocytes male Maximum ferritin MFMaximum ferritin no difference PaO2 PaO2Partial pressure of oxygen Partial pressure of oxygen Patient PBMC'sPeripheral blood mononuclear cells PEPulmonary Embolism Peripheral blood mononuclear cells Post-COVID-19 patients Postinfection progenitor cell Pulmonary embolism recruited Residual volume RVResidual volume SARS-CoV-2 SARS-COV-2 infection significant increase significantly subject the patient TLCTotal lung capacity Total lung capacity Vascular Vascular damage
[DOI] 10.1016/j.trsl.2022.01.004 [Article Type] Research article

Neutralizing antibodies to SARS-CoV-2 Omicron variant after third mRNA vaccination in health care workers and elderly subjects

의료 종사자 및 노인 대상에서 세 번째 mRNA 백신 접종 후 SARS-CoV-2 Omicron 변이체에 대한 중화 항체

Article

Published on 2022-05-012022-09-11
Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] administration age antibody Antibody responses B.1.1.529 Beta booster booster vaccination Breakthrough infection breakthrough infections collected Concentration Coronavirus disease 2019 COVID-19 cross-protective cross-reactive Delta detectable dose expected HCW HCWs Health care Health care worker health care workers IgG IgG antibody mRNA vaccination mRNA vaccine Mutation NAb NAb titer NAb titers NAbs neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody nursing home omicron Postinfection raised reduced remained SARS-CoV-2 severe COVID-19 significantly Spike protein subject subjects subsequent the antibody response the spike protein vaccination vaccine dose variant variants variants of concern WT virus
[DOI] 10.1002/eji.202149785 PMC 바로가기 [Article Type] Article