potent – Page 2 – Communicable Diseases Research

A Highly Potent SARS-CoV-2 Blocking Lectin Protein

렉틴 단백질을 차단하는 매우 강력한 SARS-CoV-2

Article

Published on 2022-07-082022-09-11
Journal: ACS Infectious Diseases
[Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected blocking cell line coronavirus coronavirus disease Coronavirus disease-19 COVID-19 death Delta demonstrated drug effective entry of SARS-CoV-2 FIVE Frequency globe Hospitalization ICU admissions IFNAR Infection lectin mouse model Mutation New coronavirus omicron Omicron variants pandemic Please add keywords. potent preventing the transmission Prophylactic Protein SARS-CoV-2 secure severe acute respiratory syndrome Coronavirus social contact Spike protein spread of COVID-19 the spike protein variants Vero E6 Wuhan strain
[DOI] 10.1021/acsinfecdis.2c00006 PMC 바로가기 [Article Type] Article

Adjuvant-Protein Conjugate Vaccine with Built-In TLR7 Agonist on S1 Induces Potent Immunity against SARS-CoV-2 and Variants of Concern

S1에 TLR7 작용제가 내장된 아주반트-단백질 접합 백신은 SARS-CoV-2 및 우려 변종에 대한 강력한 면역을 유도합니다

Article

Published on 2022-07-082022-09-11
Journal: ACS Infectious Diseases
[Category] COVID19(2023년), SARS, 변종,

Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switch

SARS-CoV-2에 대한 단일 클론 인간 IgM에 의한 강력한 중화는 클래스 전환에 의해 손상됩니다

Article

Published on 2022-07-052022-09-12
Journal: EMBO Reports
[Category] COVID19(2023년), MERS, SARS, 진단,

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2

Omicron BA.1 및 BA.2에 효과적인 강력한 인간 SARS-CoV-2 중화 IgA 및 IgG 항체

Article

Published on 2022-07-042022-09-11
Journal: The Journal of Experimental Medicine
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] animal models antibody Antibody Response Antibody responses Antiviral B-cell boost breadth candidate Cell cellular contribute convalescent COVID-19 demonstrated Diversity effective effector elicited functions Humoral immunity IgA IgA antibodies IgA antibody IgG antibodies IgG antibody immune protection memory B memory B cell memory B-cell monoclonal antibody mucosal tissue mucosal tissues Neutralizing omicron potent prevented provided Receptor-binding domain S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant serological severe COVID-19 Spike protein the receptor-binding domain the SARS-CoV-2 therapeutic efficacy Treatment Wuhan
[DOI] 10.1084/jem.20220638 PMC 바로가기 [Article Type] Article

From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease

용도 변경에서 재설계까지: SARS-CoV-2 주요 프로테아제의 강력한 억제제에 대한 보세프레비르의 최적화

Article

Published on 2022-07-042022-09-11
Journal: Molecules
[Category] COVID19(2023년), SARS, 신약개발, 치료제,

[키워드] 3C-like protease activities activity addition alpha-ketoamides alphacoronavirus approach Betacoronavirus boceprevir Complexes complexes coronavirus COVID-19 coxsackievirus Coxsackievirus B3 crystal structure crystal structures Crystallography enterovirus enterovirus 3C protease exhibited Glutamine HCoV HCoV-NL63 hepatitis C hepatitis C virus inhibitor lactam M pro main protease moderate NL63 optimization potency potent protease Protease inhibitor Proteases replacing repurposing resulting SARS-CoV-2 starting structure-based design Structure-based drug design telaprevir telaprevir. the SARS-CoV-2 treatments for COVID-19 Validity virus X-ray X-ray crystallography
[DOI] 10.3390/molecules27134292 PMC 바로가기 [Article Type] Article

Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease

중증 급성 호흡기 증후군 코로나바이러스-2 3C 유사 프로테아제의 강력한 스피로사이클릭 억제제의 구조 유도 설계

Article

Published on 2022-06-092022-09-11
Journal: Journal of medicinal chemistry
[Category] COVID19(2023년), SARS, 치료제,

Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo

Molnupiravir 및 활성 형태인 EIDD-1931, 시험관 내 및 생체 내 엔테로바이러스 감염에 대한 강력한 항바이러스 활성을 나타냄

Article

Published on 2022-05-252022-09-11
Journal: Viruses
[Category] 치료제,

A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding

SARS-CoV-2의 스파이크 수용체 결합 도메인과 친밀한 결합의 구조적 기초를 표적으로 하는 강력한 중화 나노바디

Article

Published on 2022-05-182022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Basis binding binding affinity binding site biochemical analyses characterization competing complex coronavirus delta variant Diseases domain drug candidates engage epitope In-vitro increase nanobodies nanobody neutralization neutralization activity Neutralizing overlapping potent Potential treatment raised receptor related diseases respiratory reveal S-RBD SARS-CoV-2 SARS-CoV-2 S severe acute respiratory syndrome Coronavirus spike receptor-binding domain Spread structural basis. target targeting the Spike These data Viral viral spike virus
[DOI] 10.3389/fimmu.2022.820336 PMC 바로가기 [Article Type] Article

Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination

자연 감염 후 SARS-CoV-2에 대한 자연 살해 세포 매개 항체 의존성 세포 세포 독성은 백신 접종 후보다 더 강력합니다

Article

Published on 2022-05-162022-09-12
Journal: The Journal of Infectious Diseases
[Category] COVID19(2023년), MERS, SARS, 진단,

Pseudanabaena galeata CCNP1313-Biological Activity and Peptides Production

Pseudanabaena galeata CCNP1313-생물학적 활성 및 펩티드 생산

Article

Published on 2022-05-062022-09-11
Journal: Toxins
[Category] COVID19(2023년), SARS, 치료기술,