Clinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissuesResearch Article Published on 2021-08-082022-10-27 Journal: Bioengineered [Category] COVID-19, [키워드] ACE2 ACE2 expression age analyses angiotensin-converting enzyme 2 catabolic Cell cirrhosis Clinical significance coronavirus disease COVID-19 Cox regression downregulated HCC HCC patient HCC patients Hepatocellular carcinoma investigated Kaplan–Meier mechanism molecular mechanism mRNA expression pandemic potential molecular protective role SARS-COV-2 infection survival tissue was related [DOI] 10.1080/21655979.2021.1952791 PMC 바로가기 [Article Type] Research Article
Clinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissuesResearch Article Published on 2021-08-082022-10-27 Journal: Bioengineered [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] ACE2 ACE2 expression age analyses angiotensin-converting enzyme 2 catabolic Cell cirrhosis Clinical significance coronavirus disease COVID-19 Cox regression downregulated HCC HCC patient HCC patients Hepatocellular carcinoma investigated Kaplan–Meier mechanism molecular mechanism mRNA expression pandemic potential molecular protective role SARS-COV-2 infection survival tissue was related [DOI] 10.1080/21655979.2021.1952791 PMC 바로가기 [Article Type] Research Article
Comprehensive investigation of RNA-sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndromeRNA 시퀀싱 데이터 세트에 대한 포괄적인 조사는 코로나바이러스 질병 2019 급성 호흡 곤란 증후군의 허브 유전자 및 분자 메커니즘을 보여줍니다Article Published on 2021-08-012022-09-11 Journal: IET systems biology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis approach ARDS ARDS patients CD4 Cell complement Comprehensive comprehensive analysis control group coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 ARDS patient cytokine dataset DEGs differentially expressed gene Differentially expressed genes drug eosinophil eosinophils follicular Functional enrichment analysis G-protein Glutamate GSE163426 hub genes Immune cell infiltration infiltration involved Macrophage macrophages mechanism molecular mechanism molecular mechanisms network analysis pathway patients potential molecular receptor respiratory distress Respiratory distress syndrome reveal RNA sequencing RNA-sequencing significantly syndrome T cell T cells was obtained [DOI] 10.1049/syb2.12034 PMC 바로가기 [Article Type] Article
Multimodal single-cell omics analysis identifies epithelium–immune cell interactions and immune vulnerability associated with sex differences in COVID-19다중 모드 단일 세포 omics 분석은 COVID-19의 성별 차이와 관련된 상피-면역 세포 상호 작용 및 면역 취약성을 식별합니다.Clinical Trial Published on 2021-07-302022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, [키워드] 95% CI 95% confidence interval ACE2 Admission Analysis BALF Bronchoalveolar lavage fluid BTK C-reactive protein Cell cell interaction COVID-19 COVID-19 patient COVID-19 patients disease severities disease severity elevated expression furin hazard ratio Hospital admission Hospitalization ICU identify immune immune response immune responses individual Infectious diseases Inflammatory biomarker Inflammatory marker inflammatory markers intensive care intensive care unit Interaction likelihood Macrophage macrophages male mechanism moderate Molecular medicine monocyte mononuclear cell mononuclear cells Mortality nasal network analysis neutrophil–lymphocyte ratio NRP1 observation offer outcome Patient Patient care PBMCs Peripheral blood Peripheral blood mononuclear cells potential molecular procalcitonin profile reveal SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2 positivity scRNA-seq Sequencing sera severe COVID-19 severity Sex difference single-cell Single-cell RNA-sequencing sputum samples squamous cells susceptibility Systems biology targeted intervention TLR7 TMPRSS2 Toll-like receptor toll-like receptor 7 transcriptional activation tyrosine Viral viral infection with COVID-19 [DOI] 10.1038/s41392-021-00709-x PMC 바로가기 [Article Type] Clinical Trial
Network pharmacology and molecular docking analysis on mechanisms of Tibetan Hongjingtian ( Rhodiola crenulata ) in the treatment of COVID-19Covid-19의 처리에서 티베트 홍지 (Rhodiola crenulata)의 메커니즘에 대한 네트워크 약리학 및 분자 도킹 분석Prevention, Therapy and Therapeutics Published on 2021-07-272022-08-31 Journal: Journal of Medical Microbiology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] (quercetin Analysis Anti-inflammatory applied AutoDock component contagious contagious disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine storm Cytoscape Discovery Studio disease docking Effect enrichment analyses Genes genomes GO analysis GO annotation Hongjingtian (R. crenulata) hub genes IL-17 IL-1B IL-1β IL-6 immune regulation immune response Inflammatory response inhibiting kaempferol KEGG Kyoto mechanism molecular docking molecular docking analysis network network pharmacology overcome pathway pathway enrichment Pathways potential molecular PPI PPI network Protein–protein interaction quercetin Result retrieved Rhodiola target target gene Target genes targets TCMSP database the cytokine storm TNF TNF-α Treatment [DOI] 10.1099/jmm.0.001374 PMC 바로가기 [Article Type] Prevention, Therapy and Therapeutics
The SARS-CoV-2/Receptor Axis in Heart and Blood Vessels: A Crisp Update on COVID-19 Disease with Cardiovascular Complications심장 및 혈관의 SARS-COV-2/수용체 축 : 심혈관 합병증을 가진 COVID-19 질병에 대한 선명한 업데이트Review Published on 2021-07-122022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 receptor ACE2 receptors Activation association attribute attributes axis binding Blood blood vessel blood vessels bradykinin cardiovascular cardiovascular complication cardiovascular complications cardiovascular disease chronic condition chronic conditions complement Complication components COVID-19 COVID-19 disease Defense described detrimental disease dysfunction Effect Effects endothelial Endothelial dysfunction expression pattern function glycocalyx Health Organization heart Host host defense immune cell response immune cell responses mechanism organ pandemic Patient patient with COVID-19 Platelets potential molecular provide receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus the patient thrombosis vascular leakage vessel vessels WHO World Health Organization [DOI] 10.3390/v13071346 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Subgenomic RNA Kinetics in Longitudinal Clinical SamplesMajor Articles Published on 2021-07-112022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] A549 acute respiratory syndrome analyzed Cell clinical clinical sample clinical samples clinically Cohort collected coronavirus coronavirus disease correlated COVID-19 cycle Decay kinetics detectable dimethylsulfoxide Favipiravir genomic RNA gRNA in vitro infected with SARS-CoV-2 infectiousness Kinetics Lambda longitudinal marker N-gene not differ Participants patients patients with COVID-19 persistence placebo-controlled polymerase chain potential molecular quantified Quantitative R 2 remained Remdesivir reported Result reverse transcription RNA Sample SARS-CoV-2 sgRNA sgRNAs significantly subgenomic RNA Support Swab symptom onset threshold treated Treatment Trial trials viability Viral RNA [DOI] 10.1093/ofid/ofab310 PMC 바로가기 [Article Type] Major Articles
Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1Immunology Published on 2021-07-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 bind cellular receptor chromatin immunoprecipitation chronic COPD coronavirus Coronavirus disease 2019 COVID-19 demonstrated develop Direct downregulate downregulated epithelial cells Evidence human lung identification individual loss of function lung lung epithelial cell lung epithelium mechanism mice Multiple observation patients phenotype potential molecular promoter pulmonary reported represse repression SARS-CoV-2 receptor ACE2 smoker target the SARS-CoV-2 transcriptional regulation upregulate upregulation [DOI] 10.3389/fimmu.2021.648815 PMC 바로가기 [Article Type] Immunology
Identification of Causal Genes of COVID-19 Using the SMR MethodGenetics Published on 2021-07-052022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] Analysis applied cardiac failure cardiac muscle Causal complications of COVID-19 COVID-19 COVID-19 pathogenesis COVID-19 patients eQTL FIVE genetic cause GWAS identification infected with SARS-CoV-2 instrumental variable involved Italian patient knowledge lung mechanism myocardial damage Neurological disease nine observational study occur OGT PANO1 potential molecular PPA2 regulated Research risk risk factor SCD SMR SNP Spanish UQCRH with COVID-19 [DOI] 10.3389/fgene.2021.690349 PMC 바로가기 [Article Type] Genetics
Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels?중증 COVID-19에 대한 덱사메타손: 세포 및 분자 수준에서 어떻게 작용합니까?Review Published on 2021-06-232022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] accompanied activity anti-inflammatory property Bacterial sepsis cause caused characteristic coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 develop Dexamethasone Diseases effective encoding proteins facilitate glucocorticoid glucocorticoid dexamethasone glucocorticoid receptor (GR) Glucocorticoids host cell Hypothesis hypothetical impacted infected cells Infection Infectious diseases Inflammation Influenza influenza pneumonia Innate immunity interfere life-threatening Local mechanism modulated modulating non-infected not affect pathologic Pneumonia potential molecular Protein Replication reported respiratory Respiratory failure respiratory syndrome coronavirus SARS-CoV-2 SARS-COV-2 infection Sepsis Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) severe COVID-19 severe respiratory syndrome significantly steroid systemic inflammation Treatment type I interferons (IFNs) unique Viral Viral diseases viral replication virus viruses work [DOI] 10.3390/ijms22136764 PMC 바로가기 [Article Type] Review