Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in miceArticle Published on 2022-11-012022-11-15 Journal: Inflammation research : official journal of the Eu [Category] 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome alleviate Analysis Anti-inflammatory anti-inflammatory property anti-inflammatory response ARDS CFZ Clofazimine coronavirus disease COVID-19 Critical decrease disease Diseases distress down-regulate histological change hyperimmune response IL-1β immune IMPROVE increasingly Infectious disease Inflammatory information inhibit involved lipopolysaccharide LPS lung Lung injury Macrophage macrophages mechanism mice Molecular biology pathway pharmacological mechanism potential molecular profile proliferation protective effect Protein protein expression Proteomic analysis proteomics Pulmonary edema Quantitative Signal transduction Signaling significantly survival rate syndrome therapeutic strategy TNF-α [DOI] 10.1007/s00011-022-01623-w PMC 바로가기
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthmaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] addition allergic Allergic asthma Analysis approach association Asthma asthmatic bioinformatics Biomarker can be used candidate drug candidate drugs Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression COVID-19 symptom Critical dataset datasets DEGs determine differentially expressed gene disease disease biomarker drug Effect elevated Evidence expression level Gene ontology Genes health systems hub gene identify IL-13 IL-5 Increasing Interaction interactions lung mechanism molecular molecular mechanism MUC5AC murine murine model pandemic pathway Pathway analysis Patient patients with COVID-19 phenotype potential molecular risk factor severity shared pathways statistical Systems biology systems-biology. Transcription [DOI] 10.3389/fimmu.2022.988479 PMC 바로가기
Expression Profile and Localization of SARS-CoV-2 Nonstructural Replicase Proteins in Infected CellsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome analyzed antibody antiviral strategy caused coronavirus COVID-19 pandemic determine diagnosis of SARS-CoV-2 diagnostics different time points diffusion dsRNA expression expression profile foci function Gene Expression immunofluorescence assay indicated Infection Localization mechanism mechanisms N protein nonstructural protein nsp13 nsp14 Nsp15 NSP2 Nsp3 Nsp9 Postinfection potential molecular profile Protein protein-protein interaction Proteins provide regulated replicase replicase proteins Replication responsible SARS-CoV-2 SARS-CoV-2-infected cell subcellular distribution subcellular localization suggested viral growth virus replication [DOI] 10.1128/spectrum.00744-22 PMC 바로가기
Bioinformatics and System Biology Approach to Identify the Influences of COVID-19 on Rheumatoid Arthritis류마티스 관절염에 대한 COVID-19의 영향을 식별하기 위한 생물정보학 및 시스템 생물학 접근Article Published on 2022-04-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis approach Arthritis association bioinformatics Biology candidate drug condition coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients dataset datasets DEGs differentially expressed differentially expressed gene Differentially expressed genes drug drug molecule functional functional enrichment generate hub genes identify Infection influence interactions mechanism molecular mechanism molecular mechanisms Mortality ontological Pathway analysis performed potential molecular PPI PPI network progression protein-protein interaction proteinprotein interaction rapid increase Rheumatoid rheumatoid arthritis SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease statistical System Systems biology targeted therapy Transcription transcription factor Treatment were used [DOI] 10.3389/fimmu.2022.860676 PMC 바로가기 [Article Type] Article
Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 spike protein displays sequence similarities with paramyxovirus surface proteins; a bioinformatics studyResearch Article Published on 2021-12-022022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] Analysis analyzed B cell epitope binding epitope bioinformatics Cell COVID-19 pandemic Evolution Helicase IEDB Immune Epitope Database immunological involved MHC pathogen pathogenic pathogenic coronavirus performed positive potential molecular Protein Proteins recent SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 spike protein Scientific community sequence similarity similarity Spike protein spike protein S2 ssRNA subunit surface protein T cell variant virus viruses VOCs VOIs [DOI] 10.1371/journal.pone.0260360 PMC 바로가기 [Article Type] Research Article
New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatmentLianhuaqingwen에 대한 새로운 이야기 : IL6R/IL6/IL6ST 복합체는 COVID-19 치료의 잠재적 목표입니다.Research Paper Published on 2021-11-152022-08-31 Journal: Aging (Albany NY) [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Activation addition Affect affecting AGE-RAGE signaling pathway alleviate Analysis approach Beta binding binding activity biological process clinical symptom Clinical symptoms complex COVID-19 cytokine Cytokines docking downstream enrichment analysis GeneCard hydrogen hydrogen bonds IL6 IL6R IL6R/IL6/IL6ST complex IL6ST IMPROVE Inflammatory response ingredient inhibit Interaction interleukin interleukin 6 LianhuaQingwen LianHuaQingWen (LHQW) lipopolysaccharide Luteolin mechanism molecular docking analysis N-terminal domain New Ontology pathogenic Pathways potential molecular Protein protein-protein interaction quercetin RAGE receptor regulate Regulation S protein screened severity of COVID-19 Signal transduction signaling pathway spike Spike protein subunit target TCMSP the S protein therapeutic target therapeutic targets treating COVID-19 Treatment UniProt wogonin [DOI] 10.18632/aging.203666 PMC 바로가기 [Article Type] Research Paper
Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENVCOVID-19 및 DENGUE 동시 감염에 대한 케르세틴: SARS-CoV-2 및 DENV에 의해 유발되는 중요한 숙주 신호 경로를 표적으로 하는 잠재적 치료 전략Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] alleviate Analysis bioinformatics biological function Biological functions CCL-2 Clinical characteristics clinical consequence clinical consequences Co-infection Computational biology COVID-19 Critical current CXCL8 Cytokines cytokines release Dengue drug drug trial evaluate Evidence excessive immune response functional Host IL-17 immune responses indicated Inflammation inflammatory pathway inhibit Intervention mechanism mechanisms NF-κB overlapping pathway patients pharmacological pharmacological target potential molecular PPI protein-protein interaction public health quercetin SARS-CoV-2 shown signaling pathways target targets therapeutic therapeutic strategy TNFα Toll-like receptor toll-like receptor signaling Treatment treatment of COVID-19 triggered upstream virus [DOI] 10.1093/bib/bbab199 PMC 바로가기 [Article Type] Article
Potential molecular link between the β-amyloid precursor protein (APP) and hypoxanthine-guanine phosphoribosyltransferase (HGprt) enzyme in Lesch-Nyhan disease and cancerMini Review Published on 2021-10-282022-10-27 Journal: AIMS Neuroscience [Category] COVID-19, [키워드] β-amyloid precursor protein (APP) APP gene ACE2 acid acute respiratory syndrome addition affecting alternative splicing amyloid precursor protein angiotensin-converting enzyme 2 antisense drugs antiviral drug APLP2 app can be used Cancer cancer cell Cell characterized Coagulation construction Control coronavirus coronavirus disease COVID-19 cytoplasmic demonstrated deregulated described disease disorder enzyme epigenetics epistasis example expression expression vector expression vectors GPI HPRT1 hypoxanthine phosphoribosyltransferase 1 (HPRT1) gene hypoxanthine-guanine phosphoribosyltransferase (HGprt) enzyme intermolecular interaction Invasion Lesch-Nyhan disease Migration molecular mutated nucleoside Perspective plasma membrane Potential potential molecular pre-mRNA precursor proliferation Protein provide purine Regulation reported SARS-CoV-2 spike glycoprotein the vaccine thrombosis tissue tumor cell variant X-linked [DOI] 10.3934/Neuroscience.2021030 PMC 바로가기 [Article Type] Mini Review
SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In VitroSARS – COV – 2 스파이크는 DNA 손상 복구를 손상시키고 V (D) J J 재조합을 억제합니다.Article Published on 2021-10-132022-09-01 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity affecting BRCA1 cell line clinical Clinical outcome clinical outcomes Clinical studies coronavirus coronavirus disease Coronavirus disease 2019 damage DNA DNA damage DNA damage repair DNA repair effective full-length immune immune responses Immunity impede in vitro indicated Infection influence inhibit mechanism nucleus pandemic Patient patients potential molecular Protein public health Recombination recruitment repair required respiratory SARS–CoV–2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effect significantly spike Spike protein spike-based vaccines the spike protein V(D)J recombination Vaccine [DOI] 10.3390/v13102056 PMC 바로가기 [Article Type] Article