Efficient and Sustainable Platform for Preparation of a High-Quality Immunoglobulin G as an Urgent Treatment Option During Emerging Virus Outbreaks신종 바이러스 발생 시 긴급 치료 옵션으로 고품질 면역글로불린 G를 준비하기 위한 효율적이고 지속 가능한 플랫폼Article Published on 2022-05-172022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Affect affected analyzed anti-SARS-CoV-2 approach average caprylic acid caprylic acid precipitation Concentration convalescent plasma convalescent plasma processing correlated COVID-19 COVID-19 pandemic demonstrated donors downstream Effectiveness Efficacy efficient Epidemic Final fraction IgA IgG IgG subclass IgM immunization Immunoglobulin Immunoglobulin G Infectious disease ion-exchange chromatography mass spectrometry Neutralization assay neutralization potency neutralize Neutralizing antibodies offer option outbreak overcome pandemic status Passive immunotherapy plasma polyclonal polyclonal anti-COVID-19 IgG preparation proportion provided purification Quality control reducing reduction remained significantly therapeutic transfusion reactions Treatment viral outbreak wild-type SARS-CoV-2 wild-type SARS-CoV-2 neutralization assay. [DOI] 10.3389/fimmu.2022.889736 PMC 바로가기 [Article Type] Article
Mobile intervention to promote correct hand hygiene at key times to prevent COVID-19 in the Swiss adult general population: study protocol of a multiphase optimisation strategy스위스 성인 일반 인구에서 COVID-19를 예방하기 위해 주요 시기에 올바른 손 위생을 촉진하기 위한 모바일 개입: 다단계 최적화 전략 연구 프로토콜Article Published on 2022-03-282022-09-11 Journal: BMJ Open [Category] 임상, [키워드] active control group adhere analysis of variance ANOVA approach approved behavioural Bern Combination Commission conducted conferences country COVID-19 determinant Effect effective Ethics ethics committee Evidence example feasibility Follow-up formative General population group hand hygiene hand washing Health health & hygiene identify Intervention measure Mobile pandemic peer-reviewed preparation Prevent promote protocol Public public health public health measure public health measures randomised controlled randomised controlled trial Randomised trial registration number regression analysis Research Research Ethics Safety Satisfaction sequence soap spread of COVID-19 Study protocol Switzerland thematic analysis Trial Usability variance [DOI] 10.1136/bmjopen-2021-055971 PMC 바로가기 [Article Type] Article
Engaging Native American High School Students in Public Health Career Preparation Through the Indigenous Summer Enhancement ProgramPublic Health Published on 2022-02-222022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] activities activity American Indian approach Care career center college COVID-19 develop effective enhancement Health healthcare High School IMPROVE Indigenous framework Indigenous health knowledge leadership Native Native American Navajo partnership peer mentor Philosophy Population preparation professional Program programming Public public health Qualtrics questionnaire reduce School STEM student summer university was collected [DOI] 10.3389/fpubh.2022.789994 PMC 바로가기 [Article Type] Public Health
Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein합성 비리온은 SARS-CoV-2 스파이크 당단백질의 지방산 결합 적응 면역원성을 나타냅니다.Article Published on 2022-02-142022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adaptive binding binding pocket Bioinspired materials Cell conserved convalescent COVID-19 COVID-19 progression Dexamethasone Donor fatty Fatty acid fatty acids FDA-approved drug FFAs free fatty acid function global public health glycoprotein heterogenous Host immune response immunogenicity Immunoglobulin immunoglobulins Inflammation Inflammatory integrin Live virus mechanism mimicking modulate molecular motif Mutant SARS-CoV-2 neutralization activity Neutralizing open Pathogenesis preparation pro-inflammatory proinflammatory protocol RBD Receptor binding Receptor binding domain Regulation Regulatory responsible reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein synthetic the SARS-CoV-2 Variability Viral virion vitamin K wild-type [DOI] 10.1038/s41467-022-28446-x PMC 바로가기 [Article Type] Article
Profiling Selective Packaging of Host RNA and Viral RNA Modification in SARS-CoV-2 Viral PreparationsCell and Developmental Biology Published on 2022-02-032022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Cell examined function genomic RNA Host host cells identify in viral isolate mechanism Modification modifications packaged packaging preparation Profiling RNA RNA sequencing RNAs SARS-CoV-2 SARS-CoV-2 viral selective SRP RNA the SARS-CoV-2 Transcriptome transcriptomic transfer RNA tRNA tRNAs uninfected VeroE6 cell viral life cycle viral-host interaction virion virus [DOI] 10.3389/fcell.2022.768356 PMC 바로가기 [Article Type] Cell and Developmental Biology
Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers노출되고 순진한 의료 종사자 집단에서 COVID-19 mRNA 백신에 대한 초기 항체 반응의 결정 요인Clinical Trial Published on 2022-01-012022-09-11 Journal: EBioMedicine [Category] 변종, 임상, 진단, 치료기술, 치료법, [키워드] 95% CI Adults adverse events Affect allergy Alpha Analysis analyzed antibody Antibody avidity antibody levels Antibody Response Antigen antigens avidity Barcelona Beta BNT162b2 brand center Cohort Comorbidities Comorbidity COVID-19 COVID-19 mRNA vaccine Daniel Data collection days post-infection decision determinant development dose Effectiveness Efficacy European evaluated expected Factor Gamma had no Health care Health care worker health care workers healthcare worker healthy individual heterogeneity IgA IgG IgG and IgM IgG level IgG levels Immunity indicate Infectious disease Infectious diseases Influenza Innovation maintenance manuscript Moderna mRNA mRNA vaccination mRNA vaccines mRNA-1273 naïve neutralization neutralization capacity neutralizing capacity nucleocapsid omicron Pfizer/BioNTech preparation Program reagent receiving recommendation respond response responsiveness robust SARS-CoV-2 SARS-CoV-2 spike Science second dose seropositive Severo Ochoa shown Single-dose smoking Spanish state Study design Support supported symptomatic systemic adverse effect systemic adverse effects technology the preparation union vaccination vaccine doses vaccinees variant variants variants of concern wild-type [DOI] 10.1016/j.ebiom.2021.103805 PMC 바로가기 [Article Type] Clinical Trial
The evaluation of the utility of the GENECUBE HQ SARS-CoV-2 for anterior nasal samples and saliva samples with a new rapid examination protocol새로운 빠른 검사 프로토콜을 갖는 전방 비강 샘플 및 타액 샘플에 대한 Genecube HQ SARS-COV-2의 유용성 평가Comparative Study Published on 2021-12-312022-09-24 Journal: PLoS ONE [Category] 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adjusted Chain Reaction Concordance Coronavirus-2 demonstrated evaluated molecular Nasal sample nasal samples Nasopharyngeal samples polymerase chain polymerase chain reaction positive preparation Previous studies previous study protocol provided purification real-time reverse transcriptase Real-time reverse transcriptase polymerase chain reaction respiratory respiratory sample Result reverse transcriptase RT-PCR Saliva saliva samples SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 the preparation utility was performed [DOI] 10.1371/journal.pone.0262159 PMC 바로가기 [Article Type] Comparative Study
Preparation for the challenge of heavily mutated Omicron variant심하게 돌연변이된 Omicron 변이체의 도전에 대한 준비Commentary Published on 2021-12-122022-09-10 Journal: Clinical and Translational Medicine [Category] SARS, 변종, [키워드] mutated omicron preparation variant [DOI] 10.1002/ctm2.679 PMC 바로가기 [Article Type] Commentary
Learning From a Massive Open Online COVID-19 Vaccination Training Experience: Survey StudyOriginal Paper Published on 2021-12-032022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, SARS, [키워드] addition analyzed average averaged benefit challenge Complete Course courses COVID-19 COVID-19 vaccination determine education enrolled Enrollment Evaluation had more Impact increase in information interest knowledge learning massive Massive open online course missing values objective online education pandemic participant Participants participated platform preparation Result resulting statistical study period Support survey training user experience vaccination Vaccine World Health Organization [DOI] 10.2196/33455 PMC 바로가기 [Article Type] Original Paper
Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based IsolationReview Published on 2021-11-262022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] adhesion Affect affecting Anti-inflammatory anticancer Biomolecule biosensors CAM can be used Cell Cell adhesion cellular classical Compound concerning Effect Effects Evidence experiment faster fungi Gene Expression greater Health highlighting integrin Isolation knowledge mechanism metabolite metabolites Migration movement natural natural compound plant plants preparation quantification SARS-CoV-2 SARS-CoV-2 treatment signaling pathway Stimulation surface receptor target viability virus [DOI] 10.3390/biomedicines9121781 PMC 바로가기 [Article Type] Review