Protection against omicron (B.1.1.529) BA.2 reinfection conferred by primary omicron BA.1 or pre-omicron SARS-CoV-2 infection among health-care workers with and without mRNA vaccination: a test-negative case-control study주요 오미크론 BA.1 또는 오미크론 이전 SARS-CoV-2 감염에 의해 부여된 오미크론 (B.1.1.529) BA.2 재감염에 대한 보호: mRNA 백신 접종 여부에 따른 의료 종사자를 대상으로 한 검사 음성 사례 대조 연구Article Published on 2022-09-212022-10-06 Journal: The Lancet. Infectious Diseases [Category] SARS, 진단, [키워드] 95% CI B.1.1.529 benefit case-control study conducted Control database determine diagnosed dose doses Effect Genetic greater health-care Immunity inclusion criteria Infection infection risk Laboratory likelihood Lineage mRNA mRNA vaccination mRNA vaccine negative test nucleic acid amplification Older omicron paucity of data Positive test positive test result predominant Primary infection protection Quebec, Canada reduction in Regression model Reinfection risk reduction SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test service study period tested vaccination vaccine dose variant variants was increased [DOI] 10.1016/S1473-3099(22)00578-3 PMC 바로가기 [Article Type] Article
Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue LocalizationArticle Published on 2022-09-142022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] Act adaptive adaptive immunity against SARS-CoV-2 antibody COVID-19 elicited Immunity Infection Kinetics Lineage Localization new SARS-CoV-2 Primary infection PROTECT Protein reduced right SARS-CoV-2 Spike-specific antibody Spread T cell T cell response T cells the Spike tissue-resident T cells. vaccinated individual vaccination viral replication Wuhan isolate [DOI] 10.3390/ijms231810679 PMC 바로가기
COVID-19 symptom relationship to antibody response and ACE2 neutralization in recovered health systems employees before and after mRNA BNT162b2 COVID-19 vaccineArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] ACE2 Ageusia angiotensin-converting enzyme 2 Anosmia Antibody Response Antibody titer blood sample Clinical characteristics Cook County Health cough COVID-19 immunity COVID-19 symptom COVID-19 vaccine D614G demographics dependent on evaluated Fever health system humoral IC50 immune response Immunity Infection less magnitude mRNA BNT162b2 mutant N-terminal domain neutralization NTD participant PCR-confirmed positive Post-infection Prevent Primary infection Protein provided RBD Receptor binding domain Reinfection reported symptoms SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 test severity significantly significantly higher spike subsequent Symptom Symptoms the antibody response the spike protein these symptoms vaccination [DOI] 10.1371/journal.pone.0273323 PMC 바로가기
SARS-CoV-2 reinfections during the first three major COVID-19 waves in BulgariaArticle Published on 2022-09-092022-11-16 Journal: PLoS ONE [Category] SARS, 변종, [키워드] analyzed appear Breakthrough infection Bulgaria convalescent individuals Coronaviruses COVID-19 COVID-19 case COVID-19 pandemic dataset death Delta disease evaluate Hospitalization incidence individual Infection infections moderate observé outcome outcomes pandemic Primary infection question reduction reduction in Registered Reinfection SARS-CoV-2 severity Subsequent infection the SARS-CoV-2 virus trajectory unique vaccinated individuals vaccination rate virus [DOI] 10.1371/journal.pone.0274509 PMC 바로가기
Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infectionArticle Published on 2022-09-012022-11-16 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha variant clearance Combination COVID-19 Delta epidemic peak heterogeneity Immediate immune evasion individuals Infection Italy Lineage Microbiology omicron Patient Primary infection Regional Reinfection RT-PCR test S gene SARS-CoV-2 SARS-COV-2 infection searched Sequencing Transmissibility variant variants whole genome [DOI] 10.1016/j.jiph.2022.07.013 PMC 바로가기
Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19가벼운 COVID-19 이후 1년 추적 관찰에서 체액 및 세포 면역 반응 수준Article Published on 2022-09-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] antibody antibody levels cellular Cellular immune response COVID-19 detectable disease Follow-up IFN-γ immune response memory Mild mild COVID-19 Participants Patient Primary infection resolved SARS-CoV-2 T cells T-cell T-cell immune response. [DOI] 10.1016/j.jcv.2022.105236 PMC 바로가기 [Article Type] Article
The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workersCOVID-19 위험 평가(RECOVER) 연구의 재감염: 캐나다 의료 종사자 집단의 재감염 및 혈청학 역학Observational Study Published on 2022-09-012022-09-11 Journal: Influenza and Other Respiratory Viruses [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] absence age average Characteristics Cohort conducted COVID-19 Efficacy estimation Follow-up HCWs healthcare healthcare worker IgG immune response incidence rate management median natural immunity natural infection obesity Other pandemic PCR-confirmed Primary infection prospective cohort study prospective studies Reinfection remained SARS-CoV-2 SARS-COV-2 infection serological serology Seropositivity Spike protein the spike protein Uncertainty understanding vaccination variants [DOI] 10.1111/irv.12997 PMC 바로가기 [Article Type] Observational Study
Neutralizing-antibody response to SARS-CoV-2 for 12 months after the COVID-19 workplace outbreaks in JapanArticle Published on 2022-08-302022-11-15 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome antibody booster vaccination Concentration coronavirus coronavirus disease COVID-19 declined exponential decay model infected with SARS-CoV-2 interquartile range Japan Japanese marker NAb NAb titer NAbs neutralizing antibody nucleocapsid outbreak Patient patients performed Primary infection reached SARS-CoV-2 significantly spike receptor-binding domain suggested Test tested the median the SARS-CoV-2 undetectable [DOI] 10.1371/journal.pone.0273712 PMC 바로가기
Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging VariantsArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, [키워드] acidic pH airway Airway organoids Cell cellular ciliary ciliary damage ciliated cell Culture Delta Efficiency generate higher infectivity Human imperative in vitro model Infection Infectivity Interaction maturation Model monolayer morphologically nasal nasal epithelial cell nasal epithelium nasal organoids nasopharyngeal omicron Organoid Primary infection protocol remained replicative fitness respiratory respiratory viruses robust SARS-CoV-2 tight junction tight junctions Transmissibility Transmission upper upper respiratory infection upper respiratory tract variant variants viral pathogenesis virus spread [DOI] 10.1128/mbio.01944-22 PMC 바로가기
Clinical Performance of a Standardized Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Interferon-γ Release Assay for Simple Detection of T-Cell Responses After Infection or Vaccination감염 또는 백신 접종 후 T-세포 반응의 간단한 검출을 위한 표준화된 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 인터페론-γ 방출 분석의 임상 성능Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] 19 2 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 best Cell cell response Chain Reaction clinical convalescent Convalescent patients coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 dependent on detection disease severity Euroimmun evaluated Follow-up Germany healthy IFN-γ IFN-γ response IFN-γ responses IGRA immune response individual Infection interferon interferon-γ magnitude Mild disease mild infections Neutralizing antibodies neutralizing antibody Patient performance polymerase chain reaction positive Primary infection Prospective Study Quantitative reference standard Release respiratory response reverse transcription Reverse transcription-polymerase chain reaction SARS SARS-CoV-2 SARS-COV-2 infection sensitivity serological serological test Serological tests serology severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity severity of illness simple specificity subject subjects T T-cell T-cell Response uninfected vaccination was measured Whole blood with mild disease γ release assay. [DOI] 10.1093/cid/ciab1021 PMC 바로가기 [Article Type] Article