Increased global integration in the brain after psilocybin therapy for depression Research Published on 2022-04-112022-10-05 Journal: Nature Medicine [Category] 바이오마커, 임상, [키워드] Administered Analysis baseline Brain changes changes in clinical trial correlated decrease Depression depressive disorder dose double-blind Effect flexible functional increase in Increased increases in indicated magnetic resonance imaging mechanism network Open-label Patient Placebo primary outcome measure psilocybin Randomized controlled trial robust sustained therapeutic action therapy Treatment Trial trials was recorded [DOI] 10.1038/s41591-022-01744-z [Article Type] Research
Cumulative incidence of SARS-CoV-2 and associated risk factors among healthcare workers: a cross-sectional study in the Eastern Cape, South Africa의료 종사자의 SARS-CoV-2 누적 발생률 및 관련 위험 요인: 남아프리카 이스턴 케이프의 횡단면 연구Article Published on 2022-03-182022-09-11 Journal: BMJ Open [Category] SARS, 치료기술, 치료법, 치료제, [키워드] 95% CI addition adjusted Analysis Black race blood sample Cape Characteristics Cluster Cohort community transmission COVID-19 cross-sectional cross-sectional study cumulative cumulative incidence cumulative incidence rate defined First wave HCW HCWs Health health & healthcare healthcare worker Healthcare workers HIV hospital hospitals IgG antibodies IgG antibody incidence incidence rate Infection infection control Infection prevention infection rate infection rates logistic regression model majority medium metabolic conditions mitigate no significant difference Nurse Nurses obese overweight participant PCR positive result positive SARS-CoV-2 PCR Prevention and control primary outcome measure Protein recruit risk factor Safety SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 PCR secondary outcome South Africa the epidemic the SARS-CoV-2 was used were recorded with HIV with infection women yielding [DOI] 10.1136/bmjopen-2021-058761 PMC 바로가기 [Article Type] Article
High mortality among hospitalized adult patients with COVID-19 pneumonia in Peru: A single centre retrospective cohort studyResearch Article Published on 2022-03-082022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] adjusted age association C-reactive protein cohort study Corticosteroid country COVID-19 COVID-19 patient D-dimer death rate demonstrated described Diabetes Mellitus diagnosis of SARS-CoV-2 ferritin greater highest hospital Hospitalized hypertension in-hospital mortality increased mortality inflammatory markers lactate dehydrogenase leukocytes males Mortality multivariate model National Oxygen requirement Oxygen requirements patients hospitalized patients with COVID-19 Pneumonia primary outcome measure Result retrospective cohort study single-center [DOI] 10.1371/journal.pone.0265089 PMC 바로가기 [Article Type] Research Article
Impact of personal protective equipment on neonatal resuscitation procedures: a randomised, cross-over, simulation studyRandomized Controlled Trial Published on 2022-03-012022-10-04 Journal: Archives of disease in childhood. Fetal and neonat [Category] SARS, 임상, [키워드] 95% CI Chest clinical impact cross-over healthcare worker Impact intubation limitation mean difference Neonatal resuscitation neonatology Pandemics participant Participants Personal protective equipment positive pressure ventilation PPE PPV primary outcome measure randomised randomised controlled reported Resuscitation secondary outcome measure significant difference the timing tracheal Transmission Trial [DOI] 10.1136/archdischild-2021-322216 PMC 바로가기 [Article Type] Randomized Controlled Trial
Convalescent plasma in the treatment of moderate to severe COVID-19 pneumonia: a randomized controlled trial (PROTECT-Patient Trial)중등도 내지 중증의 코비드 -19 폐렴의 치료에서의 회복기 혈장 : 무작위 대조 시험 (보호 환자 시험)Clinical Trial Published on 2022-02-152022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, 치료제, [키워드] 1:1 95% CI anti-SARS-CoV-2 antiviral activity benefit blueprint clinical Clinical improvement Clinical trial design clinical trials clinically contribute Controlled trial convalescent plasma convalescent plasma group COVID-19 COVID-19 pneumonia COVID-19 severity Data and Safety Monitoring Board double-blinded effective therapy Efficacy enrolment Evidence feasibility futility Grade 1 HIV HIV positive hospital hospital discharge hospitalized patient hospitalized patients improvement indications individuals investigated median moderate multicenter neutralizing antibody Non-invasive observational studies observational study occurred Ordinal Scale oxygen participant Participants performed placebo group plasma Pneumonia Premature Prevalence Primary outcome primary outcome measure public sector Randomized Randomized controlled trial Randomized controlled trials receive recommendation reducing Relative risk risk Safety Safety Monitoring Board saline solution scale severe COVID-19 South Africa suggested Support the placebo group therapeutic option titre transfusion-related adverse event Treatment Trial with COVID-19 World Health Organisation [DOI] 10.1038/s41598-022-06221-8 PMC 바로가기 [Article Type] Clinical Trial
Virtual Arm Boot Camp (V-ABC): study protocol for a mixed-methods study to increase upper limb recovery after stroke with an intensive program coupled with a grasp count deviceVirtual Arm Boot Camp(V-ABC): 파악 카운트 장치와 결합된 집중 프로그램으로 뇌졸중 후 상지 회복을 증가시키기 위한 혼합 방법 연구를 위한 연구 프로토콜Study Protocol Published on 2022-02-082022-09-10 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] acceptability analysed Analysis Arm Arm use assist baseline Boot Capacity collected conducted conjunction Controlled trial COVID-19 determine Efficacy Encouraging feature feedback function greater hand Impact IMPROVE include individual information intensity Intensive Intervention movement outcome participant Patient Perspective post-intervention primary outcome measure Program promote Qualitative qualitative data random random allocation Randomized controlled trial recruited rehabilitation scale secondary Secondary outcomes Seven strength stroke Study protocol Test therapist Trial Trial registration Upper extremity upper limb Wearable sensor [DOI] 10.1186/s13063-022-06047-9 PMC 바로가기 [Article Type] Study Protocol
Experiences and well-being of healthcare professionals working in the field of ultrasound in obstetrics and gynaecology as the SARS-CoV-2 pandemic were evolving: a cross-sectional survey studyObstetrics and Gynaecology Published on 2022-02-042022-10-28 Journal: BMJ Open [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] agency Analysis Anxiety association Combination country criteria cross-sectional survey Depression experience greater gynaecology HADS hcp Healthcare professional high-risk area high-risk patient highest infected patient International less moderate MOST National objective obstetrics pandemic participant Patient Personal protective equipment physician PPE Prevalence primary outcome measure Prospective public health raised reported Result SARS-CoV-2 SARS-CoV-2 pandemic Satisfaction scale setting Spain surgical the SARS-CoV-2 Ultrasonography Ultrasound were used [DOI] 10.1136/bmjopen-2021-051700 PMC 바로가기 [Article Type] Obstetrics and Gynaecology
Internet-based guided self-help comprehensive behavioral intervention for tics (ICBIT) for youth with tic disorders: a feasibility and effectiveness study with 6 month-follow-upRandomized Controlled Trial Published on 2022-02-012022-10-05 Journal: European child & adolescent psychiatry [Category] COVID19(2023년), SARS, 임상, [키워드] active control group assigned assist Child Child tic disorders clinically Comorbidity comparable Comprehensive Comprehensive behavioral intervention for tics COVID-19 COVID-19 pandemic demonstrated disorder effect size Effectiveness evaluated Evidence face-to-face delivery feasibility feasible follow-up period Gain Guided self-help impairment Internet-based CBIT. Intervention parent participant post-intervention Practice primary outcome measure Randomly ranged receive receiving reductions in Result scale severity significantly Support The effect size TIC Treatment treatment trial Youth youths [DOI] 10.1007/s00787-020-01686-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effectiveness of non-bedside teaching during the COVID-19 pandemic: a quasi-experimental studyRandomized Controlled Trial Published on 2022-01-312022-10-04 Journal: BMC Medical Education [Category] SARS, 임상, [키워드] approach assigned Bayesian benefit Clinical Competence Contact control group Course COVID-19 COVID-19 pandemic Effect Effectiveness ENhance group improvement Interpretation knowledge less neurological NEUROLOGY not differ pandemic Patient physician potential risk primary outcome measure provided question Randomly Result significantly social distancing Still student Teaching university hospital was performed [DOI] 10.1186/s12909-022-03141-z PMC 바로가기 [Article Type] Randomized Controlled Trial
The MITRE trial protocol: a study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapyMITER 시험 프로토콜 : 면역 체크 포인트 억제제 요법을받는 암 환자에서 효능 및 독성의 바이오 마커로서 미생물 군집을 평가하는 연구Study Protocol Published on 2022-01-242022-09-10 Journal: BMC Cancer [Category] 비임상, [키워드] advanced disease adverse event antibody Antigen association Bacterial Biomarker Biomarkers biopsy breath buffy coat Cancer cancer patient Cell collected correlation COVID-19 CTCAE disease Disease progression drug during treatment Efficacy evaluate Exploratory analyses genomic Gut gut microbiome help identify immune Immune checkpoint inhibitor Immune checkpoint inhibitors immunological Immunotherapy implicated IMPROVE include information inhibitor limit longitudinal lung cancer patient marker Melanoma microbial Microbiome mononuclear cell mononuclear cells mouse model non-responder Non-small cell lung cancer observation organ outcome outcomes Patient patient selection PBMCs Peripheral blood Peripheral blood mononuclear cells plasma predict Predictive primary outcome measure Prospective Study receive receiving recruited recurrence Registered Relapse renal Renal cancer responders responsible RNA secondary Secondary outcomes Stool supplementary material survival therapeutic therapeutic potential therapy tissue Toxicity transfer Treatment Treatment response Trial Whole blood [DOI] 10.1186/s12885-021-09156-x PMC 바로가기 [Article Type] Study Protocol