pro-inflammatory cytokines – Page 2 – Communicable Diseases Research

The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19

코로나19의 산화 스트레스 지수와 내피 기능 장애에 대한 알로퓨리놀의 전향적 효과

Article

Published on 2022-08-012022-09-11
Journal: Inflammation
[Category] COVID19(2023년), SARS, 바이오마커,

Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation

인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses
[DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article

Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients

입원한 SARS-CoV-2 감염 환자의 조기 퇴원 예측인자로 기준선에서의 임상, 실험실 데이터 및 염증성 바이오마커

Article

Published on 2022-07-142022-09-11
Journal: PLoS ONE
[Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] Admission AUC baseline Beta C-reactive protein category CD25 clinical collected Corticosteroid Corticosteroids cytokine Cytokines D-dimers dehydrogenase Determination discharge discharged Factor group help hospital Hospitalization Hospitalized hospitals identify IMPROVE independent Inflammatory Inflammatory biomarker interferon interleukin laboratory data laboratory parameter Lactate lactate dehydrogenase logistic regression models Macrophage Male sex Mild mild patient mild patients Negative predictive value neutrophil NLR not need NPV oxygen oxygen saturation Oxygen therapy Patient performed plasma plasma sample plasma samples Positive predictive value PPV predict Predictive Predictive value predictor pro-inflammatory cytokine pro-inflammatory cytokines Protein receptor Regression model SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 pandemic sensitivity severity Spanish specificity Transmission Treatment variable virus worsening
[DOI] 10.1371/journal.pone.0269875 PMC 바로가기 [Article Type] Article

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

예방 접종 없이 SARS-CoV-2 Omicron에 대한 제한된 교차 변이 면역

Article

Published on 2022-07-012022-09-11
Journal: Nature
[Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단,

[키워드] Activation arise Brain brains Breakthrough infection cause Cytokines Delta disease elicited ENhance expression human ACE2 receptor humans humoral immune response Immunity individual individuals induce Infection infections lead Limited lung Lung disease Lungs mice Mild Mild disease neutralization neutralize omicron other variant overexpressing pandemic pre-existing immunity pro-inflammatory cytokine pro-inflammatory cytokines question reduced replicate risk SARS-CoV-2 SARS-CoV-2 delta sera Symptoms T cells titre vaccinated individual vaccinated individuals vaccination Vaccine variant variants of concern WA1 widespread
[DOI] 10.1038/s41586-022-04865-0 PMC 바로가기 [Article Type] Article

Long COVID and long chain fatty acids (LCFAs): Psychoneuroimmunity implication of omega-3 LCFAs in delayed consequences of COVID-19

Review article

Published on 2022-07-012022-10-05
Journal: Brain, behavior, and immunity
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] accelerate accumulating acute respiratory syndrome addition Brain changes in chronic inflammation CNS Coagulation system Cognition Complication consequence coronavirus coronavirus disease COVID COVID-19 Depression disorder dysfunction dysregulated Effect EPA Evidence Fatty acid favorable effect heterogeneous HPA Immunity Impact Inflammation Intervention Long Long COVID mechanism metabolite metabolites modulating molecular mechanism mood multifactorial n-3 PUFAs Neuropsychiatric neurotransmitter offer omega-3 omega-3 PUFA Omega-3 PUFAs oxidative stress pandemic Polyunsaturated pro-inflammatory cytokines Prophylaxis Psychosocial stress PUFAs reducing SARS-CoV-2 SARS-COV-2 infection shown Sickness Spread Stage systematic review systemic inflammation tissue damage tissue homeostasis
[DOI] 10.1016/j.bbi.2022.04.001 [Article Type] Review article

K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration Research

K18- 및 CAG-hACE2 형질전환 마우스 모델 및 SARS-CoV-2: 신경변성 연구에 대한 시사점

Review

Published on 2022-06-282022-09-11
Journal: Molecules
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Autopsy Brain brain regions brain tissue CAG-hACE2 transgenic mice caused cells Central nervous system Confusion Consequences coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines demonstrated develop direct infection disorder disorders dissect Encephalitis entry receptor enzyme evaluate glial cell global pandemic hACE2 helping human Angiotensin-converting enzyme Human brain increase in infected with SARS-CoV-2 Inflammation K18 K18-transgenic mice leukocyte leukocyte infiltration life manifestation mechanism Meningitis Mental Model molecular mouse Mouse models mucosa neuroinvasion. neurological Neurological complication Neurological complications neuronal neurons olfactory Patient periphery pro-inflammatory cytokine pro-inflammatory cytokines provoke Quality of life reported responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus suggested survivor therapy transgenic Transgenic mouse Vaccine development
[DOI] 10.3390/molecules27134142 PMC 바로가기 [Article Type] Review

The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection

세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다

Review

Published on 2022-06-272022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 치료제,

[키워드] addition Administered analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine vaccine. viral replication X-linked
[DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review

Identification of COVID-19-Associated DNA Methylation Variations by Integrating Methylation Array and scRNA-Seq Data at Cell-Type Resolution

세포 유형 분해능에서 메틸화 어레이 및 scRNA-Seq 데이터를 통합하여 COVID-19 관련 DNA 메틸화 변이 식별

Article

Published on 2022-06-212022-09-11
Journal: Genes
[Category] MERS, 바이오마커,

D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir

D,L-리신-아세틸살리실레이트 + 글리신(LASAG)은 SARS-CoV-2 복제를 감소시키고 렘데시비르와 함께 추가 효과를 나타냅니다

Article

Published on 2022-06-212022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 신약개발, 치료제,

[키워드] Acetylsalicylic acid acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Additive additive effect adverse effect adverse effects Antiviral approach approved Aspirin cell culture system chip model Coagulation factors Combination complex coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cytokines disease Effect Efficacy expression glycine Healthcare system Healthcare systems in vitro inhibitory effect investigated L-lysine LASAG medication medications other diseases Patient pro-inflammation pro-inflammatory cytokine pro-inflammatory cytokines Remdesivir remdesivir. repurposing salt SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus show Therapeutic strategies therapeutic strategy these compound these compounds Vaccine viral infection while
[DOI] 10.3390/ijms23136880 PMC 바로가기 [Article Type] Article

Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia

중증 COVID-19 폐렴 노인 환자의 분자 및 세포 면역 특징

Article

Published on 2022-06-162022-09-12
Journal: Communications Biology
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] activated activated macrophage age aging anti-RBD anti-S anti-viral response antibodies CD4 CD56 Cell cellular central memory circulating Clinical outcome collagen concerning Cytokines difference disease severity elderly exacerbate feature fibrosis follicular helper T cell IgG3 immature immune immune characteristics immunological change individuals Infection Inflammation less lung macrophages monocyte mononuclear cells Patient patients percentage Peripheral blood plasma plasmablasts pro-inflammatory cytokines pro-inflammatory monocytes promote proportion reduced reported risk factor SARS-CoV-2 severe COVID-19 Severe COVID-19 pneumonia severe SARS-CoV-2 specific antibody subject T cell T cells Transcriptome transcriptomic profile
[DOI] 10.1038/s42003-022-03537-z PMC 바로가기 [Article Type] Article