A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice강력한 백혈구 변환 차단제 : GT-73은 마우스에서 LPS- 유도 된 ARD에 대한 보호 효과를 나타냈다.Article Published on 2021-07-292022-08-31 Journal: Molecules [Category] SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome addition Adhesion Molecule affecting applied ARDS BALF bind biochemical blocked blocker Blood blood cell Bronchoalveolar lavage fluid caused cell adhesion molecule covalent inhibitor COVID-19 patient COVID-19 patients Critical Cytokine storm derivatives drug candidate Effect Endothelial cell evaluate finding histological IL-1β IL-6 infiltrating Inflammation investigated leukocyte leukocyte transmigration leukocytes lung Lungs MCP-1 Migration molecule Mortality mouse model PECAM-1 peripheral tissues Platelet potent prodrug rationale reduced respiratory distress Respiratory distress syndrome responsible Showed significantly syndrome TERT transendothelial migration transmigration Treatment unique was tested was used White blood cell [DOI] 10.3390/molecules26154583 PMC 바로가기 [Article Type] Article
Decoding molnupiravir-induced mutagenesis in SARS-CoV-2SARS-CoV-2에서 몰누피라비르 유발 돌연변이 유발 해독Editors' Pick Highlight Published on 2021-06-092022-09-10 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] antiviral drug biochemical clinical trial clinical trials COVID-19 COVID-19 therapy COVID-19, coronavirus infectious disease 2019 demonstrated involved lethal mutagenesis mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular mechanism molecular mechanisms molnupiravir Mutagenesis NHC NHC, β-D-N4-hydroxycytidine nucleoside prodrug RdRp, RNA-dependent RNA polymerase RNA polymerase RNA synthesis rNTP, ribonucleoside triphosphate SARS-CoV-2 SARS-CoV, severe acute respiratory syndrome coronavirus Template therapy Viral Viral RNA Virological evidence [DOI] 10.1016/j.jbc.2021.100867 PMC 바로가기 [Article Type] Editors' Pick Highlight
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions약물 용도 스크린 스크린은 Covid-19 개입의 개발을위한 화학 기관을 식별합니다.Article Published on 2021-06-032022-08-31 Journal: Nature Communications [Category] MERS, SARS, 변종, 신약개발, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity block Calu-3 calu-3 cells candidate caused Cell cell line cell lines class combination therapies Compound compounds coronavirus COVID-19 direct-acting antiviral Direct-acting antivirals drug library Drug repurposing expressing hamsters HeLa cell HeLa cells high-content imaging High-throughput screening Host host cell identify in vitro activity Infection inhibiting inhibitors inhibitors of SARS-CoV-2 Intervention lung epithelial mechanism nelfinavir pandemic parent pharmacokinetic primary cell prodrug profiles Prophylactic receptor ACE2 reduce respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 replication sensitivity targets therapeutic drug Viral viral infection virus entry [DOI] 10.1038/s41467-021-23328-0 PMC 바로가기 [Article Type] Article
Hybrid physiologically-based pharmacokinetic model for remdesivir: Application to SARS-CoV-2렘데시비르에 대한 하이브리드 생리학적 기반 약동학 모델: SARS-CoV-2에 적용Article Published on 2021-05-012022-09-11 Journal: Clinical and translational science [Category] SARS, 치료제, [키워드] anti-SARS-CoV-2 Antiviral agents application can be used catastrophic caused Concentration condition conducted coronavirus disease Coronavirus disease 2019 COVID-19 determine effective Extracellular half-maximal effective concentration Health humans hybrid impacted imperative in vitro indicated lung Lungs metabolite mononuclear cell Multiple-dose Novel coronavirus pandemic parameter patients Peripheral blood Peripheral blood mononuclear cells pharmacokinetic prodrug profiles ranged RDV regimen regimens Remdesivir reported SARS-CoV-2 sensitivity analysis Severe acute respiratory syndrome target tissues Therapeutic treatment tissue [DOI] 10.1111/cts.12975 PMC 바로가기 [Article Type] Article
Remdesivir for COVID-19: Why Not Dose Higher?COVID-19에 대한 렘데시비르: 왜 더 높은 용량을 사용하지 않습니까?Comment Published on 2021-03-182022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 치료제, [키워드] Abstract COVID-19 drug metabolism GS-441524 metabolism prodrug Remdesivir [DOI] 10.1128/AAC.02713-20 PMC 바로가기 [Article Type] Comment
Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-( E )-2-Methyl-but-2-Enyl Nucleoside Phosphonate ProdrugsArticle Published on 2021-03-092022-10-30 Journal: Molecules [Category] Coronavirus, SARS, [키워드] antiviral activity antiviral properties approach Cell culture Compound copper-catalyzed azide-alkyne cycloaddition (CuAAC) cross cytotoxicity evaluated HBV HepG2 cells HIV Huh7 nucleoside nucleosides olefin cross metathesis Phosphonate POC prodrug SARS-CoV-2 synthesis Ultrasound [DOI] 10.3390/molecules26051493 PMC 바로가기 [Article Type] Article
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19Antiviral Agents Published on 2021-02-082022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] acute respiratory syndrome Administered Antiviral approved AT-511 AT-527 AT-9010 cells Concentration coronavirus Coronavirus-2 Coronaviruses COVID-19 cytotoxicity distribution dose effective FDA Guanosine HCoV-OC43 hepatitis C virus Huh-7 cells human airway epithelial human lung in vitro activity incubated inhibit lung metabolite nasal epithelial cell nucleotide oral pharmacokinetic pharmacokinetic data potent predict prodrug Remdesivir replication of SARS-CoV-2 required Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown subject subjects tissue treat Treatment triphosphate [DOI] 10.1128/AAC.02479-20 PMC 바로가기 [Article Type] Antiviral Agents
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19Antiviral Agents Published on 2021-02-082022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, SARS, [키워드] acute respiratory syndrome Administered Antiviral approved AT-511 AT-527 AT-9010 cells Concentration coronavirus Coronavirus-2 Coronaviruses COVID-19 cytotoxicity distribution dose effective FDA Guanosine HCoV-OC43 hepatitis C virus Huh-7 cells human airway epithelial human lung in vitro activity incubated inhibit lung metabolite nasal epithelial cell nucleotide oral pharmacokinetic pharmacokinetic data potent predict prodrug Remdesivir replication of SARS-CoV-2 required Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown subject subjects tissue treat Treatment triphosphate [DOI] 10.1128/AAC.02479-20 PMC 바로가기 [Article Type] Antiviral Agents
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19구아노신 뉴클레오티드 유사체의 이중 전구약물인 AT-527은 시험관 내 SARS-CoV-2의 강력한 억제제이자 COVID-19 치료를 위한 유망한 경구 항바이러스제입니다Antiviral Agents Published on 2021-02-082022-08-31 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Administered Antiviral approved AT-511 AT-527 AT-9010 causative agent cells Concentration coronavirus Coronavirus-2 Coronaviruses COVID-19 cytotoxicity distribution dose effective epithelial cells FDA Guanosine half-life HCoV HCoV-OC43 hepatitis C hepatitis C virus Huh-7 cells human airway epithelial human coronavirus human lung in vitro activity incubated inhibit lung metabolite nasal epithelial cell nucleotide OC43 oral pharmacokinetic pharmacokinetic data potent predict prodrug Remdesivir Replication replication of SARS-CoV-2 required respiratory Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown subject subjects tissue treat Treatment triphosphate [DOI] 10.1128/AAC.02479-20 PMC 바로가기 [Article Type] Antiviral Agents
Remdesivir: A Closer Look at Its Effect in COVID-19 Pandemic렘데시비르: 코로나19 팬데믹에 미치는 영향 자세히 살펴보기Review Published on 2021-01-012022-09-11 Journal: Pharmacology [Category] 변종, 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine affected Antiviral broad spectrum Bronchoalveolar lavage fluid cell cultures clinical evidence Clinical improvement clinical trial conducted coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic death disease Effect etiology infections inhibited life Middle East mortality rate New nucleotide oxygen Patient positive result prodrug pulmonary infiltrate Recovery time reduced Remdesivir respiratory SARS-CoV-2 selectivity index severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant effect Spread syndrome variant variants variants of SARS-CoV-2 Viral Viral load viral replication virus was tested [DOI] 10.1159/000518440 PMC 바로가기 [Article Type] Review