Drug repositioning: Progress and challenges in drug discovery for various diseases약물 재배치 : 다양한 질병에 대한 약물 발견의 진보 및 도전Review Published on 2022-04-152022-08-31 Journal: European journal of medicinal chemistry [Category] 신약개발, [키워드] addition antimicrobial Antiviral benefit Cancer candidate Candidates Clinical efficacy Combination comprehensive analysis COVID-19 pandemic de novo different disease different diseases disease Diseases drug Drug discovery drug repositioning Effect Efficiency Follow-up indication indications mechanism mechanism of action Neurological diseases other diseases Progress public health emergency Research synergistic synergistic effect [DOI] 10.1016/j.ejmech.2022.114239 PMC 바로가기 [Article Type] Review
Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory CompoundsSARS-CoV-2 3CLpro 억제제에 대한 진행 상황: SARS-CoV 3CLpro 펩티드 모방체 및 소분자 항염 화합물에서 영감Review Published on 2022-04-082022-09-11 Journal: Drug design, development and therapy [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3CLpro accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory agents anti-inflammatory effect Anti-inflammatory effects Antiviral antiviral target caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Health inhibitor inhibitors inspiration life cycle pathophysiological peptidomimetics Progress protease protease inhibitors Protein proteinase SARS-CoV SARS-CoV-2 sequence homology Sequencing severe acute respiratory syndrome Coronavirus similarity small-molecule inhibitors. viral life cycle whole-genome sequencing [DOI] 10.2147/DDDT.S359009 PMC 바로가기 [Article Type] Review
Progress in Assays of HMGB1 Levels in Human Plasma-The Potential Prognostic Value in COVID-19인간 혈장의 HMGB1 수준 분석 진행 - COVID-19의 잠재적 예후 가치Review Published on 2022-04-052022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome approach Autoimmune Autoimmune disorders Cancer Cell cells COVID-19 disease severity Diseases ELISA EMSA explain Extracellular Extracellular HMGB1 Health HMGB1 Human Human plasma immunosensor induce Inflammatory response Inflammatory responses inflammatory storm Level Occurrence outbreak Patient plasma/serum. Potential Progress Protein Rapid recent release of HMGB1 released respiratory SARS-CoV-2 virus Sepsis Severe acute respiratory syndrome survival the SARS-CoV-2 virus therapeutic window Treatment value [DOI] 10.3390/biom12040544 PMC 바로가기 [Article Type] Review
Efficacy and Sustainability of Diabetes-Specific Meal Replacement on Obese and Overweight Type-2 Diabetes Mellitus Patients: Study Approaches for a Randomised Controlled Trial and Impact of COVID-19 on Trial ProgressRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] approval baseline biochemical both group changes clinical clinical trial Compliance control groups Controlled Cost effectiveness COVID-19 COVID-19 pandemic diabete diabetes diet modification Efficacy evaluate evaluated Follow-up glycaemic control glycemic glycemic control handling HbA1c Health Impact Intervention intervention group management material meal meal replacement MONITOR obese obesity Other outcome outcomes overweight participant patients primary endpoint Progress Quality of life randomised randomised controlled receive reduction Registered registry replacement secondary endpoint Study design sustainability weight loss [DOI] 10.3390/ijerph19074188 PMC 바로가기 [Article Type] Randomized Controlled Trial
Plasmodium vivax transmission-blocking vaccines: Progress, challenges and innovationResearch article Published on 2022-04-012022-10-05 Journal: Parasitology International [Category] 비임상, [키워드] accelerate clinical development clinical trial Controlled human malaria infection (CHMI) develop Efficacy effort humans implementation malaria measure morbidity morbidity and mortality P. falciparum phase Plasmodium falciparum Plasmodium vivax Progress reached reduced reduction Research Significant significantly tested Transmission-blocking vaccine (TBV) Vaccine Vaccine development Vaccines Wheat germ cell-free protein synthesis system (WGCFS) [DOI] 10.1016/j.parint.2021.102525 [Article Type] Research article
Progress and Challenges Toward Generation and Maintenance of Long-Lived Memory T Lymphocyte Responses During COVID-19Immunology Published on 2022-02-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Activation acute respiratory syndrome B cell response CD4 CD8 cell-mediated immune challenge characterized consequence coronavirus coronavirus disease Coronavirus infection COVID-19 Cytokine storm dysfunction effective Generation identify Immunological memory Immunopathogenesis immunopathological imperative individual individuals Infection lymphocyte Lymphocytes lymphopenia maintenance memory memory response memory T cell response Neutrophils outbreak pandemic Progress reduced response SARS-CoV-2 SARS-COV-2 infection T cell T cell response T cells T memory cell Therapeutic strategies [DOI] 10.3389/fimmu.2021.804808 PMC 바로가기 [Article Type] Immunology
Implementing healthy food environment policies in New Zealand: nine years of inactionResearch Published on 2022-01-152022-10-31 Journal: Health Research Policy and Systems [Category] Coronavirus, SARS, [키워드] accountability Action applied approach COVID-19 Critical Environment evaluate Evidence expert food Food environments food insecurity Government Government policy Health healthy implementation Implementing IMPROVE increase in index INFORMAS International less lockdown majority mandatory monitoring National network New nine nutrition Obesity prevention overcome participated Policy Progress public health recommendation reflected Result resulting social determinant stimulate supplementary material Support [DOI] 10.1186/s12961-021-00809-8 PMC 바로가기 [Article Type] Research
Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugsReview article Published on 2022-01-012022-10-05 Journal: European journal of medicinal chemistry [Category] 비임상, [키워드] activity Anticoagulants Antithrombotic Antithrombotic drugs approved drug AstraZeneca bleeding blood clot candidate Cardio-cerebrovascular diseases category cause Compound COVID disease drug effective effort Factor Health high risk inhibitor mechanism Myocardial infarction onset of action Platelet Population Prevalence Progress promote receiving reported Research stroke therapeutic window thromboembolic disease thrombosis thrombotic disorder thrombotic disorders Thrombus thrombus formation unstable angina Vaccine [DOI] 10.1016/j.ejmech.2021.114035 [Article Type] Review article
Progress, pitfalls, and path forward of drug repurposing for COVID-19 treatmentArticle Published on 2022-01-012022-11-15 Journal: Therapeutic Advances in Respiratory Disease [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome antivirals approach approved Baricitinib clinical trials Compound conditions coronavirus coronavirus disease COVID-19 death Dexamethasone drug drug combination Drug repurposing effective effective drug Epidemic Evidence food growth indication International mechanism of action molnupiravir multiorgan disease patients Progress progression public health emergency Remdesivir Repurposed drug SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient selected suppress tested Tocilizumab Treatment turn viral outbreak WHO World Health Organization [DOI] 10.1177/17534666221132736 PMC 바로가기
Progress on global hepatitis elimination targets글로벌 간염 퇴치 목표 진행 상황Article Published on 2021-12-212022-09-11 Journal: World journal of gastroenterology [Category] B형 간염, SARS, 치료제, [키워드] adopted affected Blood donations coronavirus disease Coronavirus disease 2019 death deaths Donor effort global health harm reduction HBV HCV Hepatitis hepatitis B Hepatitis B vaccination Hepatitis B virus hepatitis C hepatitis C virus Hepatitis elimination incidence incidence rate Injections Mortality pandemic Progress receiving reduce Safe injections. sector Strategy target targets time Treatment Viral hepatitis World Health Assembly [DOI] 10.3748/wjg.v27.i47.8199 PMC 바로가기 [Article Type] Article