Proinflammatory response – Page 2 – Communicable Diseases Research

Immune characterization of a Colombian family cluster with SARS-CoV-2 infection

SARS-COV-2 감염을 가진 콜롬비아 가족 군집의 면역 특성

Case Reports

Published on 2021-10-152022-09-01
Journal: Biomédica [Category] MERS, SARS, 바이오마커, 진단,

[키워드] acute phase alteration anti-SARS-CoV-2 antibodies antibodies, neutralizing antibody Antibody Response anticuerpos neutralizantes células asesinas naturales CD107a CD38 CD56 CD8+ T cell CD8+ T cells Cell cells characterized clinical feature Clinical features Cluster co-expression comprehensive analysis Coronavirus infections COVID-19 cytokine Cytokines described ELISA evaluate evaluated exhibited flow cytometry Frequency functional granzyme B hallmark healthy controls HLA-DR IL-10 immune change immune changes immune marker immunofluorescence Immunotherapy indirect immunofluorescence infecciones por coronavirus infected individual infected individuals inflamación Inflammation killer cells, natural linfocitos T marker material NK cell NK cells outcome peptides perforin phenotype phenotypic plaque reduction neutralization proinflammatory cytokines Proinflammatory response reduced required RT-PCR SARS- CoV-2 SARS-COV-2 infection stimulated T cell T cells T-cell T-cells T-lymphocytes the antibody response viral peptide viral peptides were assessed
[DOI] 10.7705/biomedica.5976 PMC 바로가기 [Article Type] Case Reports

Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine storm

COVID-19 관련 사이토 카인 폭풍 관리를위한 STAT3에 대한 억제제의 컴퓨터 보조 예측

Article

Published on 2021-10-012022-08-31
Journal: Computers in biology and medicine [Category] 신약개발,

Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2

SARS-CoV-2에 대한 중간엽 줄기세포의 세포외 소포에서 Micrornas의 잠재적 치료 효과

Article

Published on 2021-09-122022-09-11
Journal: Cells [Category] SARS, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter anti-SARS-CoV-2 anti-viral response binding cellular physiology complementary components conserved coronavirus COVID-19 Cytokine storm Cytopathic effect cytopathic effects differentiation Effect EVs expressed expression extracellular vesicle Extracellular vesicles FIVE human gene human genes immune response immune responses infected cell infected cells Infection inhibiting membrane-bound mesenchymal stem cell micro-RNA microenvironment miR-181a-5p miR-23a-3p miRNA miRNAs mRNAs mutated myriad nucleic acids peptides Potential Proinflammatory response proliferation Proteins Region regulate released rescue respiratory RNAs SARS-CoV-2 SARS-CoV-2 virus sequence severe acute respiratory syndrome Coronavirus STEM suppression tested therapeutic agent therapeutic agents UTR variant variety Vesicle vesicles Viral viral gene viral genome viral infection viral replication
[DOI] 10.3390/cells10092393 PMC 바로가기 [Article Type] Article

Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2

Review

Published on 2021-08-232022-10-30
Journal: The Journal of Venomous Animals and Toxins Including Tropical Diseases [Category] COVID-19,

Characterization of the SARS-CoV-2 Host Response in Primary Human Airway Epithelial Cells from Aged Individuals

Article

Published on 2021-08-122022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

G6pd-Deficient Mice Are Protected From Experimental Cerebral Malaria and Liver Injury by Suppressing Proinflammatory Response in the Early Stage of Plasmodium berghei Infection

G6pd 결핍 마우스는 Plasmodium berghei 감염 초기 단계에서 염증 반응을 억제하여 실험적 뇌 말라리아와 간 손상으로부터 보호받는다.

Original Research

Published on 2021-08-112024-08-08
Journal: Frontiers in immunology [Category] 말라리아,

[키워드] Acute liver injury experimental cerebral malaria G6PD deficiency Plasmodium berghei Proinflammatory response
[DOI] 10.3389/fimmu.2021.719189 PMC 바로가기 [Article Type] Original Research

Effect of BCG vaccination on proinflammatory responses in elderly individuals

Research Article

Published on 2021-08-042022-10-28
Journal: Science Advances [Category] COVID-19, MERS, SARS,

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

SARS-CoV-2 N 단백질은 NLRP3 inflammasome 활성화를 촉진하여 과염증을 유도합니다

Article

Published on 2021-08-022022-09-10
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 치료법,

[키워드] accelerate activated Activation Acute inflammation aggravate ASC binding blocked caspase-1 COVID-19 COVID-19 severity cultured cell cultured cells cytokine cytokine production Cytokine storm Cytokines death facilitate hyperinflammation IL-1β IL-6 induce Infection Inflammasome inflammasomes Inflammatory response Inflammatory responses inhibitor interact Interaction Lung injury maturation mechanism mice Mouse models N protein NLRP3 NLRP3 inflammasome NLRP3 inflammasome assembly Proinflammatory cytokine proinflammatory cytokines Proinflammatory response promote Protein resulting reveal SARS-COV-2 infection SARS-CoV-2 N protein Sepsis severe symptom severe symptoms severity shown specific inhibitor Viral Viral host response with COVID-19
[DOI] 10.1038/s41467-021-25015-6 PMC 바로가기 [Article Type] Article

Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19

ACE2 및 지오텐신 1형 수용체에 대한 자가항체는 코로나19의 중증도를 증가시킵니다

Article

Published on 2021-08-012022-09-12
Journal: Journal of autoimmunity [Category] MERS, SARS, 진단,

[키워드] ACE2 affecting angiotensin Angiotensin II association AT1 autoantibody Autoimmunity blocker clinical Comorbidity Control controls COVID-19 COVID-19 group COVID-19 patient COVID-19 severity defined Diagnosis discharge disease ENhance enzyme-linked immunosorbent assays females increase in Ligand LIGHT male Mild Mild disease moderate Necrosis non-infected outcome Outcome prediction Patient Pearson positive correlation Proinflammatory response Protective RAS receptor receptors reducing renin-angiotensin system SARS-CoV-2 scale serum Serum level severe patients severity of COVID-19 significant difference significantly higher significantly lower the WHO Treatment were measured
[DOI] 10.1016/j.jaut.2021.102683 PMC 바로가기 [Article Type] Article

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism

Immunology

Published on 2021-06-252022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] 48 hour ACE2 ANPEP Apoptosis Autoimmune disease cancers cardiovascular comorbidity cardiovascular disease CEACAM1 cell death changes in complexes contribute controls coronavirus Coronavirus infection Coronaviruses COVID-19 CSF1 CSF3 CVD Cytokine storms DAMP DAMPs dataset death DPP4 Endothelial cell enzyme Epigenetic ER stress examined Express expressed expression facilitate Factor Ferroptosis hours post-infection Human hyperlipidemia IL6 Immunity Inflammation innate immune innate immune responses LPS majority marker MERS-CoV Microarray mitochondrial mitotic modulated monocyte Myelopoiesis Nrf2 nucleic acid oxidative phosphorylation PAMP Proinflammatory cytokine Proinflammatory response protein complex pyroptosis receptor regulate ROS stimulated Stimulation storm Stress subsequent Thromboembolism thrombosis TMPRSS2 TNFα trained immunity transcriptomic upregulated upregulation Viremia virus entry
[DOI] 10.3389/fimmu.2021.653110 PMC 바로가기 [Article Type] Immunology