Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 네이티브, 엔지니어링 및 드노보 디자인 리간드Review Published on 2022-10-012022-09-12 Journal: Biotechnology advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome affinity Affinity ligands antibody binding Cell concerning Contact coronavirus coronavirus disease de novo de novo design. develop diagnostic diagnostics hACE2 Host human Angiotensin-converting enzyme in vivo infect Interaction lesson Ligand ligands molecular Native natural pandemic Pandemics Patient Prophylactic Protein public health receptor reported responsible S-protein SARS-CoV-2 SARS-CoV-2 proteins Scientific community spike Spike protein the SARS-CoV-2 therapeutic therapy Vaccine virus yielding [DOI] 10.1016/j.biotechadv.2022.107986 PMC 바로가기 [Article Type] Review
Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trialRandomized Controlled Trial Published on 2022-10-012022-10-04 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 임상, [키워드] absence Administered analysed Anti-spike clinical clinical symptom clinical trial co-morbidity Community Course COVID-19 COVID-19 pandemic double blind Effect Efficacy and safety eligibility criteria evaluate Evaluating healthcare Immunoglobulin Infection nasal offer participant Placebo placebo-controlled placebo-controlled trial positive primary end point Prophylactic Prophylaxis random randomised Randomised trial Randomized reduced Result Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. significantly subject tested the primary endpoint the spike protein Treatment vaccination [DOI] 10.1016/j.jcv.2022.105248 PMC 바로가기 [Article Type] Randomized Controlled Trial
Therapeutic and palliative role of a Unani herbal decoction in COVID-19 and similar respiratory viral illnesses: Phytochemical & pharmacological perspectiveReview article Published on 2022-10-012022-10-05 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] Administered anti-bacterial Anti-inflammatory Anti-viral articles Ayurveda caused classical co-morbidities co-morbidity Complication complications Cordia coronavirus disease-2019 COVID-19 COVID-19 incidence develop drug Effect effective Efficacy English Government of India gut microbiota healthy help Home isolation Homeopathy Influenza influenza viruses information ingredient Joshānda mechanism Medicine mild patient mitigate morbidity and mortality observation Occurrence offer organ pathological change Perspective pharmacological physiological functions phytochemical Prevent Prophylactic proportion Protective reduce Regulation Research respiratory respiratory infections respiratory tract respiratory viral respiratory viral infection respiratory viral infections searched self-care severe disease Siddha the disease therapeutic therapeutic activity therapeutic benefits Unani decoction website were excluded yoga [DOI] 10.1016/j.jep.2022.115526 [Article Type] Review article
Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RAArticle Published on 2022-10-012022-11-15 Journal: RMD Open [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Analysis anti-S IgG level anti-SARS-CoV-2 anti-SARS-CoV-2 vaccine antiviral activity assessment benefit comparable correlation COVID-19 declined demonstrated HCs healthy control identify IFN-γ ELISPOT IgA IgG IgG antibody IgG level IgG response IgM isotype IgM response IgM responses immune response mRNA neutralisation assay neutralisation assays neutralising Neutralising activity Patient performed potent predict Prophylactic Receptor binding domain regimen response Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 pseudovirus T cell response titre two-dose regimen vaccination. vaccine dose Viral protein [DOI] 10.1136/rmdopen-2022-002575 PMC 바로가기
Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19Review article Published on 2022-10-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 acute respiratory syndrome alteration angiotensin-converting enzyme 2 Biomarker caused changes in Coagulation coagulation cascade coagulation factor Coagulation parameters Coagulopathy coronavirus Coronaviruses COVID-19 Cytochrome P450 enzymes cytokine Effect elevated Endothelial dysfunction enzyme In-hospital Infection Inflammation involved mechanism melatonin Mortality outcomes Patient Platelet Prophylactic RAS regulate reported risk factor SARS-CoV-2 SARS-COV-2 infection secreted severity Stress suggested the cytokine storm [DOI] 10.1016/j.lfs.2022.120866 [Article Type] Review article
Discovery and characterization of SARS-CoV-2 reactive and neutralizing antibodies from humanized CAMouseHG mice through rapid hybridoma screening and high-throughput single-cell V(D)J sequencingArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome antibodies antibody antibody humanized mice antibody repertoire Antibody Response assays can be used caused Cell clone complementary coronavirus coronavirus disease cynomolgus macaques death deficiency develop diagnostic effective Efficacy evade fully human antibody Genes humanized humans IGHV6-1 immune response immunization immunized Infection Measures medium mice MOST mutate Neutralizing neutralizing antibody pandemic patients with COVID-19 platform produced Prophylactic Protective reactive reactive and neutralizing antibodies Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD binding SARS-CoV-2 virus Sequencing Sequencing analysis significantly single-cell single-cell sequencing. the antibody therapeutic variant Virus neutralization [DOI] 10.3389/fimmu.2022.992787 PMC 바로가기
Management of dermatomyositis patients amidst the COVID-19 pandemic: Two case reportsArticle Published on 2022-09-232022-11-15 Journal: Medicine [Category] SARS, 치료제, [키워드] Anti-inflammatory therapy anti-inflammatory treatment anticoagulation Antiviral treatment Case report Characteristics Chest China coronavirus coronavirus disease cough COVID-19 COVID-19 infection dermatomyositis diagnosed diagnosed with COVID-19 Diagnosis discharged Diseases effective Epidemic Fever glucocorticoid Increased infected with COVID-19 Interstitial lung disease laboratory result male management negative PCR test Oxygen therapy pathogenic Patient patients with COVID-19 plasma Prophylactic real-time reverse-transcriptase polymerase-chain-reaction repeated RT-PCR SARS-CoV-2 Shortness of breath Spread Symptom the SARS-CoV-2 virus therapy Treatment Wuhan [DOI] 10.1097/MD.0000000000030634 PMC 바로가기
Design of Three Residues Peptides against SARS-CoV-2 InfectionArticle Published on 2022-09-222022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] amino acid sequence analyzed Antiviral approach binding biochemical coronavirus coronavirus COVID-19 pandemic cultured cell docking dose-dependent manner Effect Efficiency entry inhibitors erythrocyte Genome HCoV-OC43 human serum Infection inhibit inhibitor investigated molecular docking nucleotide nucleotide sequence Pathogens peptide peptides Prophylactic Proteases Protein SARS-CoV-2 Spike protein spike protein. Spread suggested tested the Coronaviridae the RBD the Spike the synthetic peptide therapeutic Toxicity Treatment viral infection viral infections [DOI] 10.3390/v14102103 PMC 바로가기
Issues regarding COVID-19 in kidney transplantation in the ERA of the Omicron variant: a commentary by the ERA Descartes Working GroupArticle Published on 2022-09-222022-11-15 Journal: Nephrology, dialysis, transplantation : official p [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome ambulatory patients Antiviral Antiviral agents antiviral drug Breakthrough infection Clinical practice concerning coronavirus coronavirus disease COVID-19 criteria Deceased depleting Developing dominant donors drug-to-drug interactions education Efficacy European group immunization Immunosuppression implementation Infection issue kidney kidney donation kidney transplant recipient kidney transplant recipients kidney transplantation. management omicron Prophylactic question raised recommendation risk SARS-CoV-2 Science severe disease shielding T cell transplantation Treatment treatment strategy vaccination variant widespread with COVID-19 working [DOI] 10.1093/ndt/gfac203 PMC 바로가기
SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected miceArticle Published on 2022-09-192022-11-15 Journal: PLoS Pathogens [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome Ad5-hACE2 administration antibody Antigen applied characterized control group Coronavirus-2 disease edema Efficacy evaluated Evidence examined experiments hemorrhage Human immunization Immunoglobulin increased survival induce inflammatory cell infiltration injected intranasal lung mice Mild morbidity non-specific plaque reduction neutralization Prophylactic Protective Recombinant SARS-CoV-2 RBD reduced required safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SDS-PAGE severe disease variants virus [DOI] 10.1371/journal.ppat.1010782 PMC 바로가기