Prospective clinical trial – Page 2 – Communicable Diseases Research

The future is now: our experience starting a remote clinical trial during the beginning of the COVID-19 pandemic

Randomized Controlled Trial

Published on 2021-09-072022-10-04
Journal: Trials [Category] SARS, 임상,

Mometasone furoate nasal spray in the treatment of patients with COVID-19 olfactory dysfunction: A randomized, double blind clinical trial

Randomized Controlled Trial

Published on 2021-09-012022-10-05
Journal: International immunopharmacology [Category] 임상, 치료법,

[키워드] Analysis analyzed Anosmia assigned baseline both group change Clinical characteristics clinical trial Combination Corticosteroids COVID-19 demographics double blind dysfunction evaluate identification interval Loss of Smell Mometasone furoate nasal no significant difference not significant olfactory olfactory dysfunction Patient patients with COVID-19 Primary outcome Prospective clinical trial Randomized Randomly recruited severity significant difference Smell Sodium chloride statistically significant difference subject Test Treatment two group University of Pennsylvania Visual were used
[DOI] 10.1016/j.intimp.2021.107871 PMC 바로가기 [Article Type] Randomized Controlled Trial

Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines

COVID-19 mRNA 백신에 대한 아나필락시스의 잠재적 메커니즘

Review

Published on 2021-06-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 유전자 메커니즘,

[키워드] Activation allergic Allergic reactions allergy anaphylactic anaphylaxis antibody Antigen applicability atopic cell activation clinically complement component Contact coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA vaccine COVID-19 vaccine effector cells Genetic glycol Health crisis hydrophilic hypersensitivity in vitro individual individuals less Lipid nanoparticle Lipid nanoparticles marker mast cell Mast cells mechanism messenger Messenger RNA mRNA mRNA vaccine nucleic acid packaged pandemic Pathogenesis Patient PEGylated liposome Polyethylene glycol polyethylene glycol. Polymer Potential predict Predictive Predictive value predisposition Prospective clinical trial public health crisis reaction reactivity risk severe allergic reactions suffered Vaccine vaccine administration vaccine production
[DOI] 10.1016/j.jaci.2021.04.002 PMC 바로가기 [Article Type] Review

Efficacy of the combination of modern medicine and traditional Chinese medicine in pulmonary fibrosis arising as a sequelae in convalescent COVID-19 patients: a randomized multicenter trial

회복기 COVID-19 환자의 후유증으로 발생하는 폐 섬유증에 대한 현대 의학 및 한약 조합의 효능: 무작위 다기관 시험

Clinical Trial

Published on 2021-03-182022-09-10
Journal: Infectious Diseases of Poverty [Category] SARS, 임상, 치료제,

[키워드] (pirfenidone acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Administered affected affecting age arising candidate caused Chinese Chinese Clinical Trial Registry clinical clinical manifestation clinical manifestations Combination conducted control group control groups convalescent coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 cases Critical critical condition deficiency determine Effectiveness eligible expiratory expiratory vital capacity feasible fibrosis IMPROVE Inclusion indicated infected patient infected patients lead life Lung function manifestation modern medicine mortalities Mortality multicenter Multicenter trial parallel-group participant Patient patients Pirfenidone Placebo Prospective clinical trial Prospective trial Psychology pulmonary pulmonary fibrosis Quality of life Randomized receive recorded reducing Registered registry reported respiratory SARS-CoV-2 SARS-COV-2 infection SASR-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly syndrome TCM the disease Traditional Chinese medicine Treatment treatment group Trial registration two groups vital capacity Well-being
[DOI] 10.1186/s40249-021-00813-8 PMC 바로가기 [Article Type] Clinical Trial

BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers

Observational Study

Published on 2021-01-192022-10-05
Journal: The Journal of Clinical Investigation [Category] 임상,

[키워드] acute respiratory syndrome age and sex Analysis anti-SARS-CoV-2 IgG BCG BCG vaccination Care caused Clinical characteristics clinical symptom Cohort collected coronavirus coronavirus disease COVID-19 death decrease determine develop Effects HCW HCWs Health Health care worker incidence Influenza information Innate Innate immunity Los Angele multisite nonspecific participant pneumococcal Prospective clinical trial Protective protective effect Questionnaires Randomized reported retrospective SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 seroprevalence Seroconversion Seroprevalence Therapeutic strategies vaccination Vaccine Vaccines
[DOI] 10.1172/JCI145157 PMC 바로가기 [Article Type] Observational Study

COVID-19—The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection

Review

Published on 2021-01-172022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

[키워드] ACE2 expression acute lung injury acute respiratory distress Acute respiratory infection androgen receptor antagonist animal models ARDS ARDS (Acute Respiratory Distress Syndrome) benefit caused Clinical course complications of COVID-19 concerning coronavirus coronavirus disease COVID-19 COVID-19 infection Effect evaluate Future global pandemic highest inhibitor medication MRS pandemic Patient patients with COVID-19 pleiotropic pleiotropic effect Pneumonia potassium canrenoate Potential Prevent Prospective clinical trial Pulmonary edema pulmonary fibrosis RAAS receptor reducing reduction in risk Safe SARS-CoV-2 severe pneumonia shown spironolactone syndrome the disease Therapeutic benefit therapeutic potential TMPRSS2 transmembrane serine protease WHO World Health Organization
[DOI] 10.3390/ph14010071 PMC 바로가기 [Article Type] Review

Obstacles and Considerations Related to Clinical Trial Research During the COVID-19 Pandemic

Medicine

Published on 2020-12-232022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] affecting approvals arising article Cancer catastrophic caused clinical Clinical research clinical trial Clinical trial design clinical trials Community compassionate use Confusion control groups COVID-19 COVID-19 crisis COVID-19 pandemic Data analysis data integrity Diseases effective Efficiency effort endpoints ethical concern Ethics Factor faster feasibility flexible fraction Health help include information maintain media medications misinformation multicenter trials obstacle off-label pandemic press Prospective clinical trial raised randomization released releases remote monitoring Research SARS-CoV-2 Scientific community subject Treatment Trial urgency virus
[DOI] 10.3389/fmed.2020.598038 PMC 바로가기 [Article Type] Medicine

A Prospective Study on Rapidly Declining SARS‐CoV‐2 IgG Antibodies Within One to Three Months of Testing IgG Positive: Can It Lead to Potential Reinfections?

Allergy/Immunology

Published on 2020-12-022022-10-31
Journal: Cureus [Category] COVID-19,

Promising effects of tocilizumab in COVID-19: A non-controlled, prospective clinical trial

Research article

Published on 2020-11-012022-10-05
Journal: International immunopharmacology [Category] SARS, 임상,

[키워드] Activation acute respiratory distress Administered Adverse drug reactions adverse effect analyzed C-reactive protein changes in Clinical improvement coronavirus COVID-19 Critical death dose Effect eligibility evaluate the effect evaluated IL-6 IL-6 antagonist inflammatory cascade Inflammatory cytokine initiated interleukin 6 intravenous Invasive mechanical ventilation invasive ventilation Lungs median age Mild symptom outcome Oxygenation Patient patients patients died plasma predominant Prospective clinical trial radiological released required Result SARS-CoV-2 SARS-COV-2 infection secondary severe complications Severe infection single dose SPSS software Support syndrome the median Tocilizumab tocilizumab administration
[DOI] 10.1016/j.intimp.2020.106869 [Article Type] Research article

Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?

고압산소가 COVID-19의 항염증 치료제로 안전하게 사용될 수 있습니까?

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses [Category] 비임상,

[키워드] activate acute respiratory distress acute respiratory distress syndrome Affect Anecdote anti-inflammatory treatment ARDS attenuation breath Can Case report change chemokines Clinical practice compassionate use consequence COVID-19 CT-scan cytokine Cytokines evaluated HBO Hypothesis hypoxia Inflammatory inflammatory cascade inflammatory condition inflammatory conditions Inflammatory response innate immune response innate immune system lung Mild symptom mild symptoms Organ failure oxygen Patient Pneumonitis Prevent Prospective clinical trial pulmonary CT randomized clinical trial reduce reduce mortality respiratory distress safe and reduce SARS-CoV-2 syndrome Tolerance treat Viral
[DOI] 10.1016/j.mehy.2020.110224 PMC 바로가기 [Article Type] Article