COVID-19 in patients with B cell immune deficiencyArticle Published on 2022-11-012022-11-16 Journal: Journal of Immunological Methods [Category] SARS, 변종, [키워드] approach B cell B cell immunodeficiency clinical feature clinical manifestation COVID-19 COVID-19 in patient deficiency develop disease immune Isolation management Patient PIDD Precaution Prophylaxis Prospective clinical trial risk factor SARS-CoV-2 unique vaccination Vaccine with COVID-19 [DOI] 10.1016/j.jim.2022.113351 PMC 바로가기
Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease용도 변경 항암 표피 성장 인자 수용체 억제제: 알츠하이머 병에서 신경 보호 효과의 메커니즘Review Published on 2022-09-012022-09-11 Journal: Neural Regen Res [Category] 비임상, [키워드] Alzheimer's disease Alzheimer’s disease animal model autophagy breath caused disease Disease progression downstream signaling pathway downstream signaling pathways drug drug re-positioning Effect effective enhancement epidermal epidermal growth factor epidermal growth factor receptor Evidence examined explained growth factor human epidermal growth factor receptor-2 kinase inhibitors mechanism modulation molecular mechanism neurodegeneration neurodegenerative Neurodegenerative diseases Neuroinflammation neurological manifestation neurological manifestations Numerous oxidative oxidative stress Perspective positioning Prospective clinical trial recent receptor receptor inhibitor Research shown signaling pathways Therapeutic approach tyrosine tyrosine kinase inhibitors [DOI] 10.4103/1673-5374.332132 PMC 바로가기 [Article Type] Review
Potential Cardiotoxic Effects of Remdesivir on Cardiovascular System: A Literature Review심혈관계에 대한 렘데시비르의 잠재적인 심장독성 효과: 문헌 검토Review Published on 2022-03-012022-09-11 Journal: Cardiovascular toxicology [Category] 치료제, [키워드] Abnormalities action potential adenosine amplitude Atrial fibrillation authorization binding bradycardia Cardiac arrest cardiotoxic effects Cardiotoxicity cardiovascular cardiovascular diseases Cell Chloroquine Complete Corona Corona virus COVID-19 COVID-19 disease cytotoxic effect disease dose-dependent manner Effect Effects Emergency Emergency use authorization followed by Hypotension induce inhibit Intravenous remdesivir literature metabolite mitochondrial mitochondrial RNA nucleotide nucleotide prodrug occur pandemic Patient polymerase Potential prolonged QT interval Prospective clinical trial QTC prolongation refractoriness Remdesivir review safety profile significantly sinus bradycardia Spread Treatment ventricular ventricular fibrillation Viral RNA viral RNA synthesis [DOI] 10.1007/s12012-021-09703-9 PMC 바로가기 [Article Type] Review
Hydroxychloroquine in the treatment of coronavirus disease 2019: Rapid updated systematic review and meta-analysisReview Published on 2022-03-012022-10-04 Journal: Reviews in Medical Virology [Category] SARS, 신약개발, [키워드] 95% confidence interval acute respiratory syndrome all-cause mortality Arm Care caused Clinical improvement conducted control arm coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient disease drugs effective ENhance evaluated Evidence expressed HCQ HCQ therapy Hydroxychloroquine Infection Meta-analysis methodology Mortality no significant difference not reduce pandemic Patient patients with COVID-19 Prospective clinical trial random-effects model randomised controlled trial Randomly Rapid reduction in Research risk risk of bia Safe Serious Adverse Event Spread Standard of care systematic review therapy Toxicity Treatment [DOI] 10.1002/rmv.2276 PMC 바로가기 [Article Type] Review
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individualsSARS-CoV-2에 대한 타액 IgG는 혈청 전환을 나타내며 mRNA 백신 접종 면역 저하된 개인의 혈청 중화와 상관 관계가 있습니다Article Published on 2022-02-112022-09-12 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome ALF Allogeneic Analysis Anti-SARS-CoV-2 S antibody Antigen AUC Cancer CAR-T caused center CLL CLL patient comparable coronavirus correlated Council COVID-19 disease dose Elecsy entire cohort foundation group healthy control HIV Human immunodeficiency virus IgG IgG response IgG titer immunocompromised individual immunodeficiency Immunoglobulin immunosuppressants indicate individual Infection Innovation Knut leukemia Medical Research Council mRNA BNT162b2 mRNA BNT162b2 vaccine multiplex neutralizing capacity parameter participated Patient PID Positive predictive value PPV predictive power Primary Immunodeficiency primary site Prospective clinical trial reactivity receiver operating characteristic receptor Region response responses revaccination Saliva salivary SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike antigen Seroconversion serum Serum Neutralization solid organ transplantation SOT spike IgG Stem cell transplantation Stockholm County susceptible Swedish T cell therapy transplantation vaccination vaccine response Vaccine-induced immunity were measured [DOI] 10.1016/j.medj.2022.01.001 PMC 바로가기 [Article Type] Article
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individualsNK 세포 빈도, 기능 및 BNT162b2 mRNA 항 SARS-CoV-2 예방 접종을 받은 건강하고 면역이 약한 개인에서 백신 결과와 상관 관계Research Article Published on 2022-02-082022-09-12 Journal: Molecular Medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adaptive immune responses anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 mRNA vaccine Cancer characterized clinical material clinical trial Course COVID-19 Day description Effect EudraCT frequencies Frequency healthy healthy individuals immune cells immune response immune responses Immunocompromised immunocompromised individual Immunocompromised patient Immunocompromised patients in healthy individual Innate immune cells Innate immunity mRNA mRNA vaccination mRNA vaccine mRNA-based NK cell NK cells NKG2C non-randomized Open-label outcome Peripheral blood Phenotypes positive correlation preserved Prospective clinical trial Registered Result SARS-CoV-2 supplementary material Trial registration vaccination Vaccine vaccine trial viral infections [DOI] 10.1186/s10020-022-00443-2 PMC 바로가기 [Article Type] Research Article
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer암 환자에서 COVID-19 백신에 대한 면역 반응 약화를 증가시키는 부스터 용량의 효능Article Published on 2022-01-102022-09-12 Journal: Cancer cell [Category] MERS, SARS, 진단, 치료기술, [키워드] anti-Spike IgG booster booster dose COVID-19 vaccine Efficacy immune response Immunity inhibitor Patients with cancer Prospective clinical trial reduced seroconverted seronegative patient significant increases in therapy vaccination Vaccine were assessed [DOI] 10.1016/j.ccell.2021.11.006 PMC 바로가기 [Article Type] Article
Carbon Ion Radiotherapy Acts as the Optimal Treatment Strategy for Unresectable Liver Cancer During the Coronavirus Disease 2019 CrisisPublic Health Published on 2021-12-092022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, SARS, [키워드] Act acute respiratory syndrome amplified carbon carbon ion radiotherapy Care caused China Chinese Cochrane Library collected Community coronavirus coronavirus disease COVID-19 COVID-19 crisis COVID-19 pandemic crisis database Effectiveness evaluate evaluated FIVE hospital Hospitalization IMPROVE indicated Infection International introduced Ion Liver cancer liver neoplasms Local medical resource Non-invasive pandemic Patient performed physical distance Prospective clinical trial Radiotherapy risk risk of death SARS-CoV-2 SARS-COV-2 infection searched significantly Strategy survival systematic review TACE Telemedicine therapeutic Transmission Treatment Web of Science [DOI] 10.3389/fpubh.2021.767617 PMC 바로가기 [Article Type] Public Health
A naturopathic treatment approach for mild and moderate COVID-19: A retrospective chart reviewResearch article Published on 2021-12-012022-10-05 Journal: Complementary therapies in medicine [Category] SARS, 치료법, [키워드] adverse event approach case reports changes in clinical benefit Complementary therapies conducted consecutive patient coronavirus disease correlated COVID COVID-19 COVID-19 cases COVID-19 vaccination Delay diagnosed duration of illness herbal medicine Hospitalized illness duration immune system incidence Infection integrative medicine intravenous infusions manuscript measure Mild Minerals moderate Moderate COVID-19 morbidity and mortality Naturopathic medicine Nutrition therapy objective one patient Orthomolecular therapy outcome pandemic Patient phytotherapy primary care Primary outcome progression Prospective clinical trial provided reported resolution of symptom Result retrospective SARS-CoV-2 secondary outcome seeking severe COVID-19 Side effect Symptom symptom onset Symptoms Therapeutic approach therapeutic option time Treatment vitamins with COVID-19 [DOI] 10.1016/j.ctim.2021.102788 [Article Type] Research article
Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial5 개의 면역 저하 환자 및 전향 적 개방형 임상 시험에서 건강한 대조군에서 SARS-COV-2에 대한 mRNA BNT162B2 백신의 안전성 및 효능Research paper Published on 2021-11-302022-08-13 Journal: EBioMedicine [Category] MERS, SARS, 임상, [키워드] Adverse adverse events Adverse reaction Allogeneic allogeneic hematopoietic stem cell transplantation Antibody titre antibody titres BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination CAR T, Chimeric antigen receptor T CAR-T Cell Cell therapy certain immunocompromised patient groups chronic lymphocytic leukemia clinical trial clinical trials CLL CLL, Chronic lymphocytic leukemia Control controls Council COVID-19, Coronavirus disease 2019 disorder Efficacy event excluded finding FIVE five group foundation funding generally mild group healthy control healthy controls Hematopoietic stem cell highlight HIV HIV, Human immunodeficiency virus HSCT, Allogeneic hematopoietic stem cell transplantation Human immunodeficiency virus human stem-cell transplantation Ibrutinib Immunity Immunocompromised Immunocompromised patient immunocompromised patient group Immunocompromised patients immunodeficiency disorder immunodeficiency disorders IMPROVE Infection ITT, Intention to treat Knut leukemia Lymphocytic leukemia mPP, Modified per protocol mRNA BNT162b2 vaccine mRNA vaccination mycophenolate mycophenolate mofetil occurred of BNT162b2 Open-label organ transplantation organization organizations Patient patient group patient groups PID, Primary immunodeficiency disorders PP, Per protocol primary endpoint Primary Immunodeficiency Prospective clinical trial Rate Region Safe Safety SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 second dose secondary endpoint Secondary endpoints selected serious adverse reaction Seroconversion seroconversion rate seroconverted solid organ solid organ transplantation SOT SOT, Solid organ transplantation stem cell subgroups subject Swedish T cell therapy Treatment vaccination against COVID-19 vaccine dose virus infection [DOI] 10.1016/j.ebiom.2021.103705 PMC 바로가기 [Article Type] Research paper