COVIDOSE: A Phase II Clinical Trial of Low-Dose Tocilizumab in the Treatment of Noncritical COVID-19 PneumoniaCOVIDOSE: 비임계 COVID-19 폐렴 치료를 위한 저용량 토실리주맙의 2상 임상 시험Clinical Trial Published on 2021-03-012022-09-12 Journal: Clinical Pharmacology and Therapeutics [Category] MERS, SARS, 임상, 진단, [키워드] 48 hours abrogation bacterial superinfection C-reactive protein (CRP clinical clinical recovery conducted contribute coronavirus disease COVID-19 CRP dose Drug administration evaluated Evidence Fever Follow-up Hospitalized hospitalized patient hyperinflammation IL-6 IL-6 pathway interquartile range Laboratory laboratory measure low-dose majority median time monoclonal antibody Mortality Patient patients patients died patients with COVID-19 phase Prospective trial pulmonary infiltrate Radiographic randomized, controlled trial reported Result significantly lower single-arm Tocilizumab Trial with COVID-19 [DOI] 10.1002/cpt.2117 PMC 바로가기 [Article Type] Clinical Trial
Low-Dose Radiation Therapy for COVID-19: Promises and PitfallsCommentary Published on 2021-02-192022-10-31 Journal: JNCI Cancer Spectrum [Category] COVID-19, MERS, SARS, [키워드] caused coronavirus COVID-19 Cytokine storm Healthcare system immunological low-dose majority Mortality pandemic patients Perspective promise Prospective trial pulmonary complication Pulmonary infection radiation therapy respiratory compromise SARS-CoV-2 therapeutic viable treatment viral infection [DOI] 10.1093/jncics/pkaa103 PMC 바로가기 [Article Type] Commentary
Thrombotic complications in 2928 patients with COVID-19 treated in intensive care: a systematic reviewArticle Published on 2021-02-142022-10-30 Journal: Journal of Thrombosis and Thrombolysis [Category] COVID-19, MERS, [키워드] addressed Anticoagulant anticoagulation clinical suspicion Cohort Complication conducted coronavirus Critical care Deep venous thrombosis demographics Diagnosis dose Embolism high mortality hospitalized patients ICU identify incidence Intensive intensive care management observational study occurred outcomes Patient patients patients with COVID-19 Prevalence Prospective trial prothrombotic state recommendation reported Severe COVID-19 Infection severe disease significantly higher supplementary material systematic review Thromboembolism Thromboprophylaxis thrombosis thrombotic complication Thrombotic complications Thrombotic events treated venous Venous thrombosis [DOI] 10.1007/s11239-021-02394-7 PMC 바로가기 [Article Type] Article
A pilot trial of human amniotic fluid for the treatment of COVID-19Clinical Trial Published on 2021-01-222022-10-27 Journal: BMC Research Notes [Category] COVID-19, MERS, [키워드] adverse event amniotic Amniotic fluid C-reactive protein Case series case sery clinical outcomes coronavirus COVID-19 COVID-19 patient determine discharge dose enrolled hospitalized patient Human Inflammation Inflammatory response inherent intravenous IRB limitation objective Observing Patient Prospective trial Randomized reductions in Registration Result scaled severe hypoxia Study design survived the disease therapy for COVID-19 Treatment Trial ventilatory support vertical transmission virus with COVID-19 women [DOI] 10.1186/s13104-021-05443-9 PMC 바로가기 [Article Type] Clinical Trial
A pilot trial of human amniotic fluid for the treatment of COVID-19COVID-19 치료를 위한 인간 양수의 파일럿 시험Clinical Trial Published on 2021-01-222022-09-10 Journal: BMC Research Notes [Category] 바이오마커, 임상, [키워드] adverse event adverse events amniotic Amniotic fluid C-reactive protein Case series case sery clinical outcomes coronavirus COVID-19 COVID-19 patient determine discharge dose enrolled hospitalized patient hospitalized patients Human hypoxia Inflammation Inflammatory response inherent intravenous IRB limitation objective Observing one patient Patient Prospective trial Randomized reductions reductions in Registration Result SARS CoV SARS CoV-2 scaled severe hypoxia Study design survived the disease therapy for COVID-19 Treatment Trial ventilatory support vertical transmission virus with COVID-19 women [DOI] 10.1186/s13104-021-05443-9 PMC 바로가기 [Article Type] Clinical Trial
Oral Bacteriotherapy in Patients With COVID-19: A Retrospective Cohort StudyNutrition Published on 2021-01-112022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] age Analysis antivirals bacteriotherapy cardiovascular event complementary COVID-19 CRP death died Effect Evidence Gut highlight Hospitalization Host Hydroxychloroquine ICU implication increased risk independent infecting Inflammation intestinal epithelial cells investigated low molecular weight management microbial flora microbiota modulation Mortality Mounting Observational cohort study oral oral bacteriotherapy Patient patients patients hospitalized patients treated patients with COVID-19 Pneumonia Prospective trial reduced risk regimen retrospective SARS-CoV-2 Severe COVID-19 pneumonia subject therapeutic therapy Treatment was used [DOI] 10.3389/fnut.2020.613928 PMC 바로가기 [Article Type] Nutrition
Infections and Immunotherapy in Lung Cancer: A Bad Relationship?Review Published on 2020-12-222022-10-29 Journal: International Journal of Molecular Sciences [Category] B형 간염, COVID-19, MERS, [키워드] administration affecting Analysis Antibiotic therapy anticancer Antiretroviral therapy Bacterial infections Cancer cancer patient Clinical practice clinical trial complex correlation COVID-19 described disease Evidence excluded HBV HCV Hepatitis HIV Immune checkpoint inhibitors immune system Immunotherapy impairing implication Infection Infectious disease lung cancer lung cancer patient lung cancer patients management microbiota Mortality Non-small cell lung cancer outcome Patient patient subgroup patients patients treated performed Prognosis prognostic Prospective trial reported retrospective risk of COVID-19 safety profile suggested therapy Thoracic toxicities Treatment trials viral infection viral infections virus with HIV [DOI] 10.3390/ijms22010042 PMC 바로가기 [Article Type] Review
Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial코로나19 폐렴 환자를 위한 토실리주맙. 단일군 TOCIVID-19 전향적 시험Research Published on 2020-10-212022-08-13 Journal: Journal of Translational Medicine [Category] MERS, SARS, 임상, [키워드] Analysis baseline blocks pro-inflammatory activity cause of death co-primary endpoints Cohort coronavirus COVID-19 COVID-19 patients dataset death death in COVID-19 drug toxicity effective enrolled EudraCT evaluated expected exploratory greater IL-6 intention-to-treat Interaction interleukin interleukin-6 involved ITT lethality rate lethality rates mechanical respiratory Mortality multicenter multivariable logistic regression NCT04317092 negatively affected null hypothesis Older age PaO2/FiO2 ratio Pathogenesis Patient patients patients with COVID-19 Phase 2 Pneumonia pro-inflammatory activity prognostic variable prognostic variables prospective cohort Prospective trial reduced Registration reported respiratory Respiratory Support Result Safety single-arm statistically significant Steroids subject Support survival Tocilizumab TOCIVID-19 Toxicity Trial use of steroid was used [DOI] 10.1186/s12967-020-02573-9 PMC 바로가기 [Article Type] Research
Low dose anti-inflammatory radiotherapy for the treatment of pneumonia by covid-19: A proposal for a multi-centric prospective trialResearch article Published on 2020-09-012022-10-05 Journal: Clinical and Translational Radiation Oncology [Category] 치료법, [키워드] adhesion molecules Anti-inflammatory anti-inflammatory cytokine anti-inflammatory effect caused contagious control arm control group COVID COVID-19 cytokine release dose Efficacy Efficiency evaluate evaluated experimental arm exploratory expression feasibility Health include increase in Inflammatory inflammatory cascade interfere interstitial pneumonia low-dose lung mechanism morbidity Non-invasive overall mortality oxidative stress paO2/fiO2 PaO2/FiO2 ratio patients patients with COVID-19 pharmacological treatment Pneumonia primary end-point Prospective clinical trial Prospective Study Prospective trial radiation therapy Radiotherapy receive reducing resources respiratory complication Respiratory function Secondary objective severity the patient therapy Treatment viral infection [DOI] 10.1016/j.ctro.2020.06.005 [Article Type] Research article
Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review코로나19 폐렴 치료를 위한 저선량 방사선치료: 증례보고, 절차, 문헌고찰Review Published on 2020-08-202022-09-01 Journal: Strahlentherapie Und Onkologie [Category] MERS, 신약개발, 진단, 치료제, [키워드] Administered approach Case report country COVID-19 COVID-19 pandemic COVID-19 pneumonia Cytokine storm decrease deficit described Disinfection dose Effectiveness emergency services Inflammatory marker intensive care intubation invasive respiratory support literature review low dose low-dose Low-dose radiotherapy outbreak oxygen oxygen support Patient Pneumonia Practitioner practitioners presenting Prevent procedure Prospective trial Radiotherapy reported respiratory serum Toxicity Transport Treatment treatment planning ventilator ventilatory Viral pneumonia Volume with COVID-19 [DOI] 10.1007/s00066-020-01675-z PMC 바로가기 [Article Type] Review