Differential Ubiquitination as an Effective Strategy Employed by the Blood-Brain Barrier for Prevention of Bacterial Transcytosis혈액-뇌 장벽이 세균의 세포간 이동을 예방하기 위해 사용하는 효과적인 전략으로서의 차별적 유비퀴틴화Article Published on 2022-01-182024-08-24 Journal: Retinal cases & brief reports [Category] 폐렴구균 감염증, [키워드] autophagy blood-brain barrier K48-ubiquitination K63-ubiquitination proteasomal degradation proteasome Streptococcus pneumoniae ubiquitin topology ubiquitination
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19Article Published on 2021-11-152022-10-28 Journal: Biology [Category] COVID-19, [키워드] “COVID-19 “cytokine storm” 20S proteasome acute respiratory syndrome addition analyzed ARDS association AUC Biomarker blood draw cause clinical clinical picture collected Coronavirus-2 Course COVID-19 COVID-19 disease COVID-19 patients COVID-2019 Critical critical appraisal demonstrated described disease disintegration Disseminated intravascular coagulation elevated endpoints evidenced Heat shock help high-risk patient higher risk hospital Hospital admission HSP27 Human hyperinflammation identify immune immune system immunological in-hospital mortality independent indicated Infection Inflammatory Inflammatory cytokine Interpretation invasive ventilation investigated mechanism Mortality notable outbreak oxygen support pandemic pathophysiology Patient patients with COVID-19 plasma Prognostic factor Prognostic factors proteasome Protein Relevance remained Research risk SARS-CoV-2 Sepsis septic patient serological data serum serum sample simple sST2 ST2 subsequent therapeutic interventions undergo Ventilation with COVID-19 [DOI] 10.3390/biology10111186 PMC 바로가기 [Article Type] Article
Proteasomal activator 28 gamma stabilizes hepatitis B virus X protein by competitively inhibiting the Siah-1-mediated proteasomal degradationArticle Published on 2021-11-122023-06-11 Journal: Biochemical and Biophysical Research Communication [Category] B형 간염, [키워드] HBx Hepatitis B virus PA28γ proteasome Siah-1. [DOI] 10.1016/j.bbrc.2021.09.028
COVID-19 in multiple-myeloma patients: cellular and humoral immunity against SARS-CoV-2 in a short- and long-term view다발성 골수종 환자의 코로나19: 단기 및 장기 관점에서 SARS-CoV-2에 대한 세포 및 체액 면역Case Reports Published on 2021-10-182022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] MERS, SARS, 진단, 치료기술, [키워드] Affect affecting anti-SARS-CoV-2 antibody antibody levels Antibody titer Antibody titers CD4+ T-cell cell activation cellular Cellular immune response Clinical management Combination Continuous Course COVID-19 Decision-making deficiency detectable diagnosed with COVID-19 Disease progression help humoral Humoral immunity Hypogammaglobulinemia IgA IgG antibodies IgM IgM and IgG immune response Immunity immunodeficiency immunological immunomodulatory drugs Immunosuppression infections information inhibitors Innate immunity Isolation lenalidomide Measures memory monoclonal antibodies monoclonal antibody Multiple Multiple myeloma Myeloma neutralizing antibody titers neutropenia Patient performed positive proteasome receiving recommendation remained robust SARS-CoV-2 supplementary material supportive therapy T cell T cell activation T-cell tested the patient therapy treated Treatment underlying disease virus-neutralizing virus-neutralizing antibody [DOI] 10.1007/s00109-021-02114-x PMC 바로가기 [Article Type] Case Reports
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection시겔라 유비퀴틴 리가제 IpaH7.8은 가스더민 D를 분해 대상으로 삼아 파이로ptosis를 방지하고 감염을 가능하게 한다.Article Published on 2021-10-132024-08-22 Journal: Cell Host & Microbe [Category] 세균성이질, [키워드] GSDMD Inflammasome proteasome pyroptosis Shigella ubiquitin ligase virulence
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasomeArticle Published on 2021-09-282024-08-28 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] antimalarial drug cryo-EM peptide boronate Plasmodium proteasome
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entryTMPRSS2 발현을 위한 고처리량 스크린으로 SARS-CoV-2 진입을 제한할 수 있는 FDA 승인 화합물 식별Article Published on 2021-06-232022-09-10 Journal: Nature Communications [Category] MERS, SARS, 비임상, [키워드] 2019-nCoV ACE2 breath Cell cell entry cell surface receptor clinical trial Compound compounds Concentration concentrations coronavirus COVID-19 disease COVID-19 infection DCAF1 DDB1 Degradation dependent on drug E3 ubiquitin ligase Effect entry of SARS-CoV-2 epithelial cells expression global pandemic halofuginone help High-throughput screening homoharringtonine Host host protease host proteases human clinical trial human clinical trials Human plasma identify in vitro library limit lung epithelial cell modulate pathogenic coronavirus pharmacokinetic data proteasome Protein reduce reducing responsible SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 glycoprotein SARS-COV-2 infection Screen Serine serine protease serine protease TMPRSS2 small molecule Small molecules spike stability surface expression surface receptor the cell TMPRSS2 TMPRSS2 expression TMPRSS2 level TMPRSS2 levels TMPRSS2 protein [DOI] 10.1038/s41467-021-24156-y PMC 바로가기 [Article Type] Article
High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As AntimalarialsArticle Published on 2021-06-112024-08-28 Journal: ACS Infectious Diseases [Category] 말라리아, [키워드] High Throughput Screening malaria drug discovery nonpeptidomimetic inhibitors Plasmodium falciparum proteasome
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized MiceArticle Published on 2021-04-192024-08-28 Journal: Angewandte Chemie (International Ed. in English) [Category] 말라리아, [키워드] inhibitors malaria proteasome selectivity Therapeutics
Phase 1b trial of isatuximab, an anti‐CD38 monoclonal antibody, in combination with carfilzomib as treatment of relapsed/refractory multiple myelomaClinical Trials Published on 2021-03-182024-09-04 Journal: Cancer [Category] 대상포진, [키워드] Carfilzomib immunomodulatory Isatuximab monoclonal antibody pharmacokinetics proteasome [DOI] 10.1002/cncr.33448 PMC 바로가기 [Article Type] Clinical Trials