Reactive Oxygen Species Induction by Hepatitis B Virus: Implications for Viral Replication in p53-Positive Human Hepatoma CellsArticle Published on 2024-06-152024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] HBx Hepatitis B virus p53 proteasome reactive oxygen species Siah-1 [DOI] 10.3390/ijms25126606 PMC 바로가기 [Article Type] Article
Chronic Administration of Non-Constitutive Proteasome Inhibitor Modulates Long-Term Potentiation and Glutamate Signaling-Related Gene Expression in Murine Hippocampus비구성 프로테아좀 억제제의 만성 투여가 생쥐 해마에서 장기 강화 및 글루타메이트 신호 전달 관련 유전자 발현을 조절한다.Article Published on 2023-05-032024-08-19 Journal: International Journal of Molecular Sciences [Category] 파상풍, [키워드] non-constitutive proteasomes ONX-0914 proteasome proteasome inhibitor synaptic plasticity.
E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structureArticle Published on 2023-02-102024-09-05 Journal: Structure (London, England : 1993) [Category] update2024, [키워드] AlphaFold biomolecular condensates E3 ligase E6AP proteasome UBE3A UBQLN1/2 [DOI] 10.1016/j.str.2023.01.012 PMC 바로가기 [Article Type] Article
Tumor Suppressor p53 Inhibits Hepatitis B Virus Replication by Downregulating HBx via E6AP-Mediated Proteasomal Degradation in Human Hepatocellular Carcinoma Cell LinesArticle Published on 2022-10-212023-06-12 Journal: Viruses [Category] B형 간염, [키워드] E6-associated protein HBx Hepatitis B virus p53 proteasome [DOI] 10.3390/v14102313 PMC 바로가기
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome InhibitorsArticle Published on 2022-10-182024-08-29 Journal: Med Instrum [Category] 말라리아, [키워드] antimalarial agents Plasmodium falciparum proteasome
GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virusGanoderma microsporum의 단백질인 GMI는 SARS-CoV-2 Spike-pseudotyped 바이러스의 감염을 완화하기 위해 ACE2 분해를 유도합니다Article Published on 2022-08-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression activating addition alleviate bafilomycin blocking Cell cell viability cells cloned Cytometry deaths Degradation determined by downregulated dynamin Effect Efficacy examined exhibit expressing flow cytometry fluorescence microscopy fluorescent function Fungal immunomodulatory proteins fungal protein GFP GMI green fluorescent protein HEK293T host cells Human immunomodulatory immunomodulatory functions in vitro induce infecting Infection inhibited inhibiting Interaction lentiviral lung epithelial lung tissue lysosome macrophages mechanism MG132 mice MTT nebulizer not affect overexpressing pandemic Prevent prevention proteasome Protein protein level pseudovirus reduced rescued respiratory responsible S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection Severe acute respiratory syndrome spike Spike protein Therapeutic strategies triggered Type Vaccine viability viral infection virus was determined western blot [DOI] 10.1016/j.phymed.2022.154215 PMC 바로가기 [Article Type] Article
The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9bDeubiquitinase USP29는 ORF9b의 프로테아좀 분해를 방지하여 SARS-CoV-2 독성을 촉진합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Antiviral biological processes canonical carboxyl caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense Degradation deubiquitinase deubiquitination. develop E3 ubiquitin ligase E3 ubiquitin ligases effort eGFP enhancement Evidence Health healthy help Host host defense hosts IFN IFN-I IKKɑ Immunity inhibit inhibiting innate immune response Intensive interact Interaction IκB mechanisms Modification mRNA level NF-κB NF-κB activation Orf9b Particles pathogen pathogenicity pathway Prevent Preventing proliferation proteasomal proteasome Protein regulate Regulation Replication replication-competent SARS-CoV-2 restrict resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Signaling subsequent Transcription Type I IFN type I interferon ubiquitin USP29 viral infections virulence [DOI] 10.1128/mbio.01300-22 PMC 바로가기 [Article Type] Article
Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screenCRISPR/Cas9 화면을 통한 SARS-CoV-2의 제한 요인으로 DAXX 식별Article Published on 2022-05-042022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antiviral activity basal Cell culture CRISPR cytoplasmic DAXX Degradation dependent on DNA virus DNA viruses domain expression Factors functional human cells identification identify independent independent of Infection inhibitor interferon life cycle limit Localization mechanism nuclear over-expression Papain-like protease pathway PLPro PML promote proteasome Protein Replication replication of SARS-CoV-2 restrict restriction factor retroviruses SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle SARS-CoV-2 replication scaffold protein the SARS-CoV-2 Trigger turn [DOI] 10.1038/s41467-022-30134-9 PMC 바로가기 [Article Type] Article
Fast and Effective Prediction of the Absolute Binding Free Energies of Covalent Inhibitors of SARS-CoV-2 Main Protease and 20S ProteasomeSARS-CoV-2 주요 프로테아제 및 20S 프로테아좀의 공유 억제제의 절대 결합 자유 에너지의 빠르고 효과적인 예측Article Published on 2022-05-042022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accelerated activities Amino acid applicability approach binding affinities binding affinity binding free energy cause computational method covalent bond COVID-19 COVID-19 pandemic Degradation drug Effect effective electrophilic energetics energy enzyme evaluate exploration Free globe inhibitor inhibitors inhibitors of SARS-CoV-2 interactions M pro modulation powerful tool prediction protease proteasome Protein protocol public health emergency reaction reservation robust SARS-CoV-2 shown significantly target Therapeutic strategies variant warhead water [DOI] 10.1021/jacs.2c00853 PMC 바로가기 [Article Type] Article
Transcriptome Analysis of Peripheral Blood Mononuclear Cells in SARS-CoV-2 Naïve and Recovered Individuals Vaccinated With Inactivated Vaccine비활성화 백신 접종을 받은 SARS-CoV-2 미경험 및 회복된 개인의 말초 혈액 단핵 세포의 전사체 분석Cellular and Infection Microbiology Published on 2022-02-032022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Analysis Antibody detection approval Booster vaccine choice correlation COVID-19 COVID-19 vaccine dose Genes global public health help Host immune response immune system inactivated Inactivated vaccine individual innate immune pathway mechanism molecular multiple dose multiple doses naïve individual performed peripheral proteasome reaction mechanism recovered reduce Research RNA-Seq SARS-CoV-2 serum IgG single dose strong immune response the epidemic transcriptome analysis transcriptomics vaccination Vaccination strategy [DOI] 10.3389/fcimb.2021.821828 PMC 바로가기 [Article Type] Cellular and Infection Microbiology