Impact of Immunotherapies on SARS-CoV-2-Infections and Other Respiratory Tract Infections during the COVID-19 Winter Season in IBD PatientsArticle Published on 2022-08-242022-11-15 Journal: Canadian journal of gastroenterology & hepatology [Category] SARS, 진단, [키워드] addition age analysed association Cohort collected Course COVID-19 COVID-19 infection death died Evidence First wave Frame General population Germany hospital hotspot IBD ICU Immunoglobulin immunomodulator Immunotherapy Impact increased risk infection risk Inflammatory bowel disease inhibitor majority medication Munich occurred Older age Other Oxygen treatment Patient patients patients died positive Prevent problem protective role question receive reduced respiratory respiratory tract respiratory tract infection Respiratory tract infections SARS-CoV-2 SARS-COV-2 infection season severe COVID-19 significantly subject Support susceptible symptomatic tested the healthy therapy TNF tract Treatment Winter [DOI] 10.1155/2022/3469789 PMC 바로가기
Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural IntegritySARS-CoV-2와 결합된 니코틴은 세포 생존, 염증 반응 및 미세구조 완전성에 영향을 미칩니다Article Published on 2022-08-222022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] A549 A549 cell analyzed caused Cell cellular damage characterized chromatin Combination COVID-19 cytokine production Cytokines Cytopathic effect cytopathic effects cytoplasmic cytosol cytotoxicity decrease dose Endoplasmic reticulum expression level extracellular space feature granules human lung human lung adenocarcinoma A549 cells IL10 IL6 IL8 infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines integrity LPS mechanism of action membrane rupture Modification modifications modulate necroptosis Nicotine poly(I:C) positive proinflammatory proinflammatory cytokines protective role pyroptosis response SARS-CoV-2 TNFα Vero E6 cell were used [DOI] 10.3390/ijms23169488 PMC 바로가기 [Article Type] Article
Survival of Vaccine-Induced Human Milk SARS-CoV-2 IgG, IgA and SIgA Immunoglobulins across Simulated Human Infant Gastrointestinal Digestion인간 유아 위장 소화를 통한 백신 유도 모유 SARS-CoV-2 IgG, IgA 및 SIgA 면역글로불린의 생존Article Published on 2022-08-172022-09-12 Journal: Nutrients [Category] SARS, 진단, [키워드] adenovirus-based antibody Breastfeeding breastmilk COVID-19 COVID-19 pandemic Degradation digestion dose evaluated Evidence Gastrointestinal GI Tract help Human human milk IgA IgA antibody IgG Immunoglobulin immunoglobulins in vitro Inconclusive Infant information intestinal lactating milk mother mRNA-based vaccine natural infection passive immunity persistence Pfizer/BioNTech produced PROTECT protective role protocol recent reduced reduction SARS-CoV-2 SARS-CoV-2 IgG secretory IgA SIgA the SARS-CoV-2 virus the spike protein the vaccine transfer vaccination Vaccine women [DOI] 10.3390/nu14163368 PMC 바로가기 [Article Type] Article
Heterologous immunity induced by 1st generation COVID-19 vaccines and its role in developing a pan-coronavirus vaccineArticle Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] acute respiratory syndrome adaptive addition COVID-19 COVID-19 pandemic COVID-19 vaccine cross-reactive develop Evolution Heterologous heterologous immunity highlight Hospitalization illnesses Immunity immunization individual Infection mechanism Mortality MOST mutated mutated variant other coronaviruses pan-coronavirus vaccine pandemic Prevent PROTECT protective role Protein SARS-CoV-2 SARS-CoV-2 antigens T cell the Spike understanding universal vaccine development. Vaccine Vaccine development variant viral strains virulent virus strain [DOI] 10.3389/fimmu.2022.952229 PMC 바로가기
Antibodies against Spike protein correlate with broad autoantigen recognition 8 months post SARS-CoV-2 exposure, and anti-calprotectin autoantibodies associated with better clinical outcomesArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute COVID-19 Anti-RBD antibody anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies antibody Antibody Response associations autoantibodies autoantibody autoantigen Autoantigens Autoimmune Autoimmunity baseline breadth Clinical outcome Cohort controls convalescent correlation COVID-19 COVID-19 disease COVID-19 infection cross-reactive Future healthcare worker healthy highlighting human protein IgG IgG antibody Immunity individual moderate omicron pathology PCR plasma positive correlation post infection Post-infection protective role Protein Receptor binding domain response SARS-CoV-2 SARS-CoV-2 antigen shown significantly higher spike subunit sustained symptom severity target the healthy uninfected control variant spike Wuhan-Hu-1 [DOI] 10.3389/fimmu.2022.945021 PMC 바로가기
SARS-CoV-2 infection in cancer patients on active therapy after the booster dose of mRNA vaccinesmRNA 백신 추가 접종 후 활성 요법을 받는 암 환자의 SARS-CoV-2 감염Article Published on 2022-08-012022-09-11 Journal: European journal of cancer (Oxford, England : 1990 [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] active treatment anti-Spike IgG booster booster dose Booster vaccine cancer patient Cancer patients center Cohort COVID-19 Delta dose Follow-up geometric mean geometric mean titer geometric mean titers Health care Health care worker healthy subject healthy subjects indicate investigated Italy lowest malignancies median value microneutralization Microneutralization assay mRNA vaccine mRNA vaccines Nasopharyngeal swab Neutralizing antibodies neutralizing antibody Occurrence occurrence of COVID-19 omicron Omicron variants outbreak Patient positive potential risk proportion protective role required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants serological Siena solid malignancies solid malignancy solid tumor solid tumors tested the median the SARS-CoV-2 therapy Treatment tumors Type university Vaccine variants [DOI] 10.1016/j.ejca.2022.05.018 PMC 바로가기 [Article Type] Article
A Complementary Union of SARS-CoV2 Natural and Vaccine Induced Immune ResponsesSARS-CoV2 자연 및 백신 유도 면역 반응의 상호 보완적 연합Review Published on 2022-07-132022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] benefit booster contributed COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines death deaths effective immune immune imprinting immune response immune responses Immunity individual induced infected individuals Infection less maintain natural natural immunity Neutralizing neutralizing antibody omicron pandemic progressed Protective protective role reducing Reinfection response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV2 union vaccination Vaccine Vaccines variant [DOI] 10.3389/fimmu.2022.914167 PMC 바로가기 [Article Type] Review
Evaluation of Bi-Lateral Co-Infections and Antibiotic Resistance Rates among COVID-19 Patients in Lahore, PakistanObservational Study Published on 2022-07-062022-10-05 Journal: Medicina [Category] 임상, [키워드] Acinetobacter antibiotic Antibiotic resistance antibiotic stewardship Bacteria Bacterial bacterial co-infection Bacterial infections carbapenem resistant Enterobacteriaceae Care clinical sample collected Complication conducted coronavirus COVID-19 COVID-19 patient Critically ill cultures diagnosed diagnostic methods diffusion E. coli Enterobacteriaceae Enterococcus Escherichia coli gold standard highest hospital hospital acquired infections. Hospital admission illnesses increase in Infection infections Influenza inhibitory concentration isolate isolates material methicillin morbidity and mortality MRSA National oxygen Patient positive Prevalence protective role Rate resistance Result Risk factors shown Staphylococcus aureus susceptibility tested Treatment viral respiratory [DOI] 10.3390/medicina58070904 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation예방 접종 또는 감염 후 유도된 SARS-CoV-2 스파이크 및 핵단백질 특이적 항체는 고전적 보체 활성화를 촉진합니다Article Published on 2022-07-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] activated Activation antibodies antibody Antibody responses Antigen binding C1q C1q binding C3b cascade classical classical pathway complement Complement activation Complement cascade complement components Complement pathway component components convalescent COVID-19 COVID-19 patient COVID-19 patients deposition disease status downstream Effect ELISA assay groups hospitalised IgG1 induced median N antigen NHC non-hospitalised non-infected not differ nucleocapsid presence of antibody protective role Protein Protein binding response responses SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera severe COVID-19 specific antigen spike spike glycoprotein subject the disease vaccination Vaccine vaccinees Variability Viral Viral antigen viral antigens [DOI] 10.3389/fimmu.2022.838780 PMC 바로가기 [Article Type] Article
Role of IgM Memory B Cells and Spleen Function in COVID-19COVID-19에서 IgM 기억 B 세포와 비장 기능의 역할Review Published on 2022-06-302022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, 치료기술, [키워드] administration Algorithm B cell Care Cell clinical impact Clinical outcome condition contribute COVID-19 dysfunction Evidence Evolution Follow-up follow-up study function Germinal center Hospital admission hyposplenism IgM IgM memory B cell immune Infection infections management memory B memory B cell memory B cells memory response mucosal other coronaviruses outlined Patient patients with COVID-19 Plasma cells Prognosis protective role reduced resulting role SARS-CoV-2 spleen subset Support Vaccine virus [DOI] 10.3389/fimmu.2022.889876 PMC 바로가기 [Article Type] Review