Old drug, new Trick? The rationale for the treatment of COVID-19 with activated protein C오래된 약, 새로운 트릭? 활성화된 단백질 C로 코로나19를 치료하는 근거Article Published on 2021-04-012022-09-11 Journal: Medical Hypotheses [Category] 치료법, 치료제, [키워드] activated activated protein C adaptive Antiviral agents antiviral treatments apixaban approach Aspirin clinical trial Coagulation consequence convalescent plasma COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 therapeutics COVID-19 therapeutics. current described dysregulated immune response evaluated followed by heparin heparins Hope Hypothesis identify immune immune response immunomodulator immunomodulators Infection Inflammatory mechanism monoclonal antibodies Protein protein C researcher steroid Steroids therapeutic interventions therapeutic target Therapies therapy treating COVID-19 patient Treatment [DOI] 10.1016/j.mehy.2021.110537 PMC 바로가기 [Article Type] Article
SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lungSARS-CoV-2는 폐에서 항응고제 및 섬유소 용해 유전자 발현을 억제합니다Research Article Published on 2021-03-082022-09-10 Journal: eLife [Category] SARS, 유전자 메커니즘, 진단, [키워드] Analysis Anticoagulant BALF Blood coagulation bronchoalvelolar Bronchoalveolar lavage fluid C1-Inhibitor circulating clearance Coagulation Coagulopathies Coagulopathy COVID-19 COVID-19 patient COVID-19 patients driver Drivers endothelial examined expression Extensive FIBRIN fibrinolysis fibrinolytic Gene Expression Human identify inflammatory disorders initiate Kinin limit Local lung Lungs molecular mechanism molecular mechanisms mRNA level mRNA levels not increased pathway Pathways promote Protein protein C receptor reduced SARS-CoV-2 significantly suppresse thrombomodulin tissue Tissue Factor transcript transcriptional profile transcriptional profiles transcripts urokinase while [DOI] 10.7554/eLife.64330 PMC 바로가기 [Article Type] Research Article
Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation패혈증 상태의 내피병증: 혈관 내 응고에 대한 기계적 통찰력Review Published on 2021-03-082022-09-11 Journal: Critical Care [Category] 임상, [키워드] activated Activation Anticoagulant Antithrombin Cell Coagulation coagulation factor Coagulation factors coagulation pathway conditions COVID-19 decrease Disseminated intravascular coagulation (DIC) domain Endothelial cell endothelial cells endotheliopathy example expression Extracellular histones function In vitro studies inhibitor intravascular coagulation Lipopolysaccharide (LPS) pathophysiology pathway Phosphatidylserine physiological plasma plasma membrane proof Protein protein C Proteins recombinant thrombomodulin resulting Sepsis septic supplementary material suppressed thrombomodulin thrombosis tissue Tissue Factor [DOI] 10.1186/s13054-021-03524-6 PMC 바로가기 [Article Type] Review
Coagulation profile of COVID-19 patients admitted to the ICU: An exploratory studyICU에 입원한 COVID-19 환자의 응고 프로파일: 탐색적 연구Research Article Published on 2020-12-152022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 치료기술, [키워드] abnormality addressed alteration anticoagulation Antithrombin aPTT baseline both groups change characterized Coagulation coagulation tests complex Conventional COVID-19 patient D-dimer Day decrease exploratory study fibrinogen Fibrinogen levels fibrinolysis fibrinolytic groups hypercoagulability ICU in both group in both groups INR Laboratory test Laboratory tests less Longitudinal evaluation magnitude median objective organ dysfunction Patient plasma plasminogen Platelet Protein protein C protein S remained Result severity slight increase SOFA SOFA score study period two groups were measured with COVID-19 [DOI] 10.1371/journal.pone.0243604 PMC 바로가기 [Article Type] Research Article
Circulating Biomarkers of COVID-19-Triggered Endotheliopathy: From Conjecture to CertaintyConference abstract Published on 2020-11-042022-10-05 Journal: Blood [Category] 바이오마커, [키워드] Activation acute phase reactants Admission affecting analyzed appear Biomarker Blood board Boehringer Ingelheim certainty chest imaging circulating clinical collected complement Complication Conjecture contribute Control controls coronavirus Course COVID-19 COVID-19 patient COVID-19 patients Critical Culture Degradation detection diagnostic disease download dsDNA elevated ELISA test endothelial Endothelial cell endothelial damage endothelial function endothelial injury evaluated figure form funding healthy donor Hoffmann-La Roche Hospitalization identify immunofluorescence Inflammatory information Injury janssen Jazz Lancet Level marker Mortality multiple organs Nasopharyngeal swab NET NETs Neutrophil extracellular trap no significant difference non-critically ill patient non-infectious not differ notable Novartis pathophysiology Patient plasma Pneumonia positive potentially life-threatening prognostic protein C pulmonary complication radiological reduced responsible Result Science Septic shock Sharp Siemens Healthineers significantly significantly higher significantly increased significantly lower speaker Stress syndrome systemic inflammatory response Takeda the disease therapeutic intervention Therapeutics thrombotic vWF were assessed were measured were used [DOI] 10.1182/blood-2020-142311 [Article Type] Conference abstract
Role of Both Protein C and Antithrombin III as Predictors of Stage of Liver Disease in Chronic Viral Hepatitis B or C Infected PatientsArticle Published on 2020-01-012023-06-13 Journal: Endocrine, metabolic & immune disorders drug targets [Category] B형 간염, [키워드] Anticoagulants antithrombin III chronic liver disease hepatitis B hepatitis C protein C [DOI] 10.2174/1871530319666190529092555
EPCR and Malaria Severity: The Center of a Perfect Stormarticle Published on 2017-04-302024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] cytoadhesion EPCR malaria PfEMP1 Plasmodium protein C [Article Type] article
The role of EPCR in the pathogenesis of severe malariaarticle Published on 2016-05-312024-09-01 Journal: Chang Gung Med J [Category] 말라리아, [키워드] endothelial protein C receptor malaria Plasmodium falciparum protein C Vascular endothelium [Article Type] article
High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in BeninArticle Published on 2015-05-012024-08-29 Journal: Nanoscale [Category] 말라리아, [키워드] cerebral malaria EPCR Plasmodium protein C sEPCR.