Oral cavity infection by the SARS-CoV-2: emphasizing the essence of masking and peptide therapeuticsCorrespondence Published on 2022-01-102022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] ACE2 ACE2 receptor binding blood pressure homeostasis carried cathepsin L cellular cleavage conformational change COVID-19 cytoplasm disease epithelial function functions glycoprotein healthcare high expression level high risk host’s body human ACE2 receptor Infection information inhibit nucleocapsid oral cavity oral mucosa other proteases peptide Protease inhibitor Protein proteolytic cleavage Regulation Saliva SARS-CoV-2 secretion supplementary material therapeutic TMPRSS2 viral loads viral spike [DOI] 10.1186/s43042-022-00213-z PMC 바로가기 [Article Type] Correspondence
Emerging SARS‐CoV‐2 variants can potentially break set epidemiological barriers in COVID‐19Review Published on 2021-11-292022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] absence accumulating ACE2 acute respiratory syndrome age antibodies antigenic sites binding causing changes in Comorbidities coronavirus coronavirus disease COVID‐19 COVID‐19 demographic disease severity driven by ENhance enzyme epidemiological Epidemiology Evidence expression female glycosylation greater Harbor Health healthy individual healthy individuals induce Infection interactions mechanisms Mutation mutations neutralization other proteases outcome pandemic prolonged viral shedding Proteases proteolytic cleavage RBD recent receptor receptor‐binding domain reduced repeated Replication resulting SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 variants sequence severe disease severe inflammation Sex show significant changes in Spike protein symptomatic the disease the RBD the spike protein tissue injury Transmissibility vaccination Vaccine vaccine breakthrough infection variant variants Viral load viral loads viral spike protein virus virus–host interaction Waves widespread women [DOI] 10.1002/jmv.27467 PMC 바로가기 [Article Type] Review
Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 ( TMPRSS2 ) and SARS-CoV-2인간 막 횡단 프로테아제 세린 2 (TMPRSS2) 및 SARS-COV-2에서의 미스 센스 변이체의 계산 분석Research Article Published on 2021-10-192022-09-10 Journal: BioMed Research International [Category] 변종, [키워드] 3D structure activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADP-ribosylation association cleaving conserved ConSurf coronavirus decrease Deleterious deleterious effect deleterious effects Effect evaluated facilitate Human identify missense variant mutant posttranslational modification PROCHECK progression Prostate cancer protease Protein proteolytic cleavage PROVEAN PTMs Ramachandran plot respiratory S protein SARS-CoV-2 Serine serine 2 severe acute respiratory syndrome Coronavirus SIFT stability susceptibility target cell target cells Template tested the S protein TMPRSS2 transmembrane variant Viral viral entry [DOI] 10.1155/2021/9982729 PMC 바로가기 [Article Type] Research Article
Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 ( TMPRSS2 ) and SARS-CoV-2Research Article Published on 2021-10-192022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] 3D structure activating acute respiratory syndrome ADP-ribosylation association cleaving conserved ConSurf coronavirus decrease Deleterious deleterious effect Effect evaluated facilitate Human identify missense variant mutant posttranslational modification progression Prostate cancer protease Protein proteolytic cleavage PROVEAN Ramachandran plot SARS-CoV-2 serine 2 SIFT stability susceptibility target cell tested the S protein TMPRSS2 transmembrane variant viral entry [DOI] 10.1155/2021/9982729 PMC 바로가기 [Article Type] Research Article
Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses리포터 발현 바이러스를 이용한 생체 내 SARS-CoV-2 감염 역학 분석423 Published on 2021-10-122022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme antibody causative agent coronavirus COVID-19 COVID-19 pandemic CoVs cultured cell deleted deleting dissemination dynamic effective enzyme exhibited expressed expressing expression level fluorescent followed by Frame Genes hACE2 high stability identify in vitro in vivo in vivo imaging Infection K18 locus lung MONITOR neutralize noninvasive nucleocapsid Open reading frame ORF Pathogenesis pathogenicity Protein proteolytic cleavage public health replaced REPLACED BY Replication reporter reporter expression reporter gene reporter genes reporter viruses respiratory retained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance the SARS-CoV-2 the viral nucleocapsid therapeutic intervention therapeutic interventions threat transgenic mice Treatment upstream Venus Viral viral infection viral replication virus viruses whole organism wild-type [DOI] 10.1073/pnas.2111593118 PMC 바로가기 [Article Type] 423
Cell Entry of Animal CoronavirusesReview Published on 2021-10-012022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] animal Animal coronaviruses attachment factor binding Cell cell binding cell entry component CoV CoVs disease effective effort ENhance highlight Host host range host restriction factor humans Infection inhibit interactions involved knowledge membrane fusion molecular mechanism outbreak over pandemic Pathogenesis positive-sense proteolytic cleavage provide recent finding receptor Research restriction factor RNA virus SARS-CoV SARS-CoV-2 Spike protein stimulated therapeutic strategy tissue tropism virus entry virus infection [DOI] 10.3390/v13101977 PMC 바로가기 [Article Type] Review
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potentialSARS-CoV-2 감염 중 단백질 분해를 특성화하여 치료 가능성이 있는 바이러스 절단 부위 및 세포 표적 식별Article Published on 2021-09-212022-09-10 Journal: Nature Communications [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] Anti-viral Antibody testing Antigen benefit biology of SARS-CoV-2 causative agent cell line cellular cellular protease cleavage cleavage site cleavage sites COVID-19 COVID-19 pandemic death dose-dependent reduction drugs targeting event identify in vitro infections inhibit inhibit SARS-CoV-2 mass spectrometry MYLK Papain pathogen protease Protease activity Proteases Protein proteolysis proteolytic cleavage provide resource responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease SARS-CoV-2 replication shown significant increases in siRNA SRC substrate target targets therapeutic potential titres treat tyrosine vaccinate Vaccine Viral viral infection Viral proteins [DOI] 10.1038/s41467-021-25796-w PMC 바로가기 [Article Type] Article
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro포도상구균 장독소 B 초항원에 대한 단일 클론 항체는 시험관 내에서 SARS-CoV-2 진입을 억제합니다Comment Published on 2021-09-022022-09-12 Journal: Structure (London, England : 1993) [Category] MERS, SARS, 진단, [키워드] 6D3 assays caused CDR2 Cell children common cold COVID-19 cytokine Cytokine storm explain furin furin-cleavage site furin-like cleavage site high affinity human coronavirus in vitro Infection Inflammatory inhibit Live virus mAb MIS-C monoclonal antibody motif Neutralizing Neutralizing antibodies overlap polybasic Prevent protease proteolytic activity proteolytic cleavage PRRA S1/S2 cleavage site SARS-CoV-2 entry SEB severe COVID-19 patients Spike protein staphylococcal staphylococcal enterotoxin B superantigen syndrome the cytokine storm the SARS-CoV-2 TMPRSS2 treating COVID-19 utility viral entry [DOI] 10.1016/j.str.2021.04.005 PMC 바로가기 [Article Type] Comment
SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective ImmunityS1/S2 절단 부위에서 돌연변이를 갖는 SARS-CoV-2는 약화된 독성을 나타내고 보호 면역을 부여합니다Research Article Published on 2021-08-242022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] activate affecting airway animal model attenuation B.1.1.7 Bearing body weight Body weight loss cause cell tropism cellular entry cleavage cross-react exhibited furin furin cleavage site furin protease growth hamster hamsters Host immunogens infected with SARS-CoV-2 Infection Inflammatory response inoculated investigated Lineage lineages Mild motif mutant mutants Mutation Neutralizing antibodies P.1 parental Pathogenesis pathogenic pathway polybasic potential benefit potential benefits protective neutralizing antibodies protective neutralizing antibody proteolytic cleavage respiratory S gene S1/S2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Site spike Spike protein subsequent the spike protein tissue variant Viral viral growth weight loss [DOI] 10.1128/mBio.01415-21 PMC 바로가기 [Article Type] Research Article
A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein ActivationReview Article Published on 2021-07-242022-10-28 Journal: Scientifica [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affecting angiotensin-converting enzyme 2 applied assumption cellular entry Computational approaches coronavirus Coronavirus infections COVID-19 pandemic develop epithelial cell expressed expression facilitated groups Host host cell host cell membrane Infection infection rate inhibiting inhibition inhibitor membrane membrane fusion MERS Middle East pathological protease Proteases proteolytic cleavage recent receptor reducing responsible review SARS-CoV-2 severity sex- shown spike Spike protein subsequent syndrome the SARS-CoV-2 therapy TMPRSS2 transmembrane serine protease Variation virus [DOI] 10.1155/2021/2706789 PMC 바로가기 [Article Type] Review Article