Bilateral basal ganglia ischemia associated with COVID-19: a case report and review of the literatureCase Report Published on 2021-11-222022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Asian Asymptomatic Bilateral Brain caused Confusion coronavirus coronavirus disease Coronavirus disease 2019 cough Effect effective event Fever ganglia Infection Ischemia lower limb management multi-organ dysfunction Neuroimaging neurological sign NEUROLOGY Pain Patient prothrombotic state radiology reported SARS-CoV-2 Shortness of breath [DOI] 10.1186/s13256-021-03165-x PMC 바로가기 [Article Type] Case Report
Incidence and Predictors of Thrombotic Complications in 4742 Patients with COVID-19 or Other Acute Infectious Respiratory Diseases: A Propensity Score-Matched StudyArticle Published on 2021-10-262022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute infectious respiratory disease administration adverse impact age Anticoagulant bleeding cause clinical clinical variable Complication COVID-19 COVID-19 group cumulative Cytokine storm Diabetes Mellitus diagnosed Diagnosis disease etiological excessive inflammation high risk hypoxia In-hospital incidence no significant difference occurred Other Patient patients with COVID-19 predictor Prognosis prothrombotic state respiratory Respiratory disease SARS-COV-2 infection severe COVID-19 significant difference solid cancer stroke subpopulation Thromboembolic event Thromboembolic events thrombosis thrombotic event treated two group two groups venous Venous thrombosis with COVID-19 [DOI] 10.3390/jcm10214973 PMC 바로가기 [Article Type] Article
Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19Tie2 활성화는 COVID-19의 혈전성 내피 기능 장애로부터 보호합니다Research Article Published on 2021-10-222022-09-10 Journal: JCI Insight [Category] SARS, 유전자 메커니즘, [키워드] accompany Activation AKB-9778 alteration angiopoietin Anticoagulant Antithrombotic assessment Autopsy changes in circulating Coagulation Cohort Concentration COVID-19 demonstrated disease severity Disruption dysfunction endothelial Endothelial cell endothelial cells Endothelial dysfunction endothelial marker Endothelial markers expression Genes highest highlight Inflammation inhibit inhibited Microvascular thrombosis Mild moderate Patient patients with COVID-19 Pharmacologic phenotypic plasma procoagulant promoted property PROTECT prothrombotic prothrombotic state rationale receptor released reversed severe COVID-19 Signaling small molecule survival therapy These data thrombosis treated Trial upregulated Vascular Biology [DOI] 10.1172/jci.insight.151527 PMC 바로가기 [Article Type] Research Article
Combined anticoagulant and antiplatelet therapy is associated with an improved outcome in hospitalised patients with COVID-19: a propensity matched cohort studyObservational Study Published on 2021-10-012022-10-05 Journal: Open Heart [Category] SARS, 임상, [키워드] 95% CI adjusted Admission all-cause mortality Anticoagulant anticoagulation antiplatelet Antithrombotic clinical cohort study Combined component COVID-19 COVID-19 infection Cox regression analysis disease Efficacy evaluate hospitalised patient ICU ICU admission identify implicated In-hospital in-hospital mortality increase in Infection intensive care Invasive mechanical ventilation less management mechanical ventilation microvascular angina Observational cohort study Occurrence outcome Patient patient population patients with COVID-19 Pharmacology Primary outcome Prophylactic prothrombotic state randomised controlled trial reduced risk Respiratory disease retrospective risk secondary outcome statistically significant difference subgroup TAC therapeutic anticoagulation therapy Thromboembolic events thrombotic treat Treatment university hospital was performed with COVID-19 [DOI] 10.1136/openhrt-2021-001785 PMC 바로가기 [Article Type] Observational Study
The Cross-Talk between Thrombosis and Inflammatory Storm in Acute and Long-COVID-19: Therapeutic Targets and Clinical CasesCase Report Published on 2021-09-232022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activate Activation acute phase acute respiratory syndrome addition Adhesion Molecule administration adopted alteration anti-inflammatory properties Anticoagulant anticoagulant therapy Anticoagulants blood chemistry cardiovascular risk Cell characterized circulating clinical clinical expression Coagulation coagulation cascade Coagulation factors coagulation parameter Coagulopathy complicate component Coronavirus-2 COVID-19 COVID-19 patient COVID-19 patients criteria cross-talk cytokine cytokine expression Cytokines death rate Disseminated intravascular coagulation DOAC DOACs Efficacy endothelial damage evaluate factor Xa Growth factors IMPROVE Inflammation Inflammatory inhibit leucocyte LMWH Local long-COVID-19 oral anticoagulant outcomes PARs Patient patients persistence PF4 Platelet promote inflammation prothrombotic state receptor SARS-CoV-2 storm suggested Survivors Symptom syndrome target thrombin Treatment Venous Thromboembolism VTE [DOI] 10.3390/v13101904 PMC 바로가기 [Article Type] Case Report
Randomized study of rivaroxaban vs. placebo on disease progression and symptoms resolution in high-risk adults with mild COVID-19Randomized Controlled Trial Published on 2021-09-152022-10-04 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, [키워드] 1:1 95% CI age Anticoagulant black body mass index Comorbidities Comorbidity coronavirus Course COVID COVID-19 COVID-19 progression Critical Day Disease progression effective therapy Endpoint enrolled female Gate groups Hispanic Infection inhibitor interim analysis investigated Mild moderate MRI participant Patient Placebo Pneumonia Prevent primary efficacy endpoint progression progressive disease prothrombotic state public health Randomized reduce Result risk rivaroxaban SARS-CoV-2 SARS-COV-2 infection severe disease stratified Symptom symptomatic [DOI] 10.1093/cid/ciab813 PMC 바로가기 [Article Type] Randomized Controlled Trial
Endothelial Cell Activation by SARS-CoV-2 Spike S1 Protein: A Crosstalk between Endothelium and Innate Immune CellsArticle Published on 2021-09-142022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] “cytokine storm” activated Activation addressed adhesion molecules alteration amplify cell activation chemokine chemokines Coagulopathy Combination conditioned contributing to COVID-19 Crosstalk CXCL10/IP-10 Cytokines decrease endothelial activation Endothelial cell endothelial cells Endothelial dysfunction Endothelium Evidence expression human lung human monocyte-derived macrophage hyperinflammatory state ICAM-1 impairment increased expression Infection Inflammatory response Innate Macrophage macrophages MDM mechanism medium multi-organ failure occur Pathogenesis pro-inflammatory mediator pro-inflammatory mediators Protein prothrombotic state released S1 protein SARS-CoV-2 severe COVID-19 spike spike S1 protein THBD the disease the S1 protein the SARS-CoV-2 the spike protein tissue Vascular vascular homeostasis VCAM-1 [DOI] 10.3390/biomedicines9091220 PMC 바로가기 [Article Type] Article
Two Different Clinical Presentations of Acute Limb Ischemia Caused by Acute Thrombotic Events in COVID-19Cardiology Published on 2021-09-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Acute limb ischemia Arterial thrombosis caused clinical Coronavirus disease 2019 COVID-19 COVID-19 diagnosis diagnosed Endotheliitis global pandemic Hypercoagulable state Infection initial Ischemia limb lower limb manifested men Patient presentation prothrombotic state Severe case thrombosis with COVID-19 [DOI] 10.7759/cureus.17916 PMC 바로가기 [Article Type] Cardiology
Myocardial Pathology in COVID-19-Associated Cardiac Injury: A Systematic ReviewReview Published on 2021-09-082022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] abstracts ACE2 Acute heart failure Affect age Analysis analyzed Angiotensin-converting enzyme Autopsy cardiac caused CD3+ CD68+ macrophages CD8+ changes in clinical assessment conducted consequence Coronavirus disease 2019 COVID-19 COVID-19 patients database death died diffusion disease emerging disease heart heart failure histologic inclusion criteria infiltration inflammatory state information interquartile range IQR item lymphocyte men myocarditis Myocardium Necrosis offer organ organs pathological change pathological finding pathological findings Patient Perspective positive Postmortem Protein prothrombotic state reflected Reporting Research Respiratory failure review risk SARS-CoV-2 searched systematic review systemic inflammatory response tested the SARS-CoV-2 virus variable vessel women [DOI] 10.3390/diagnostics11091647 PMC 바로가기 [Article Type] Review
COVID-19, cardiovascular diseases and cardiac troponins코로나19, 심혈관 질환 및 심장 트로포닌Review Published on 2021-09-032022-09-11 Journal: Future Cardiology [Category] MERS, 바이오마커, [키워드] Biomarker cardiac troponin cardiovascular disease cardiovascular diseases Clinical outcome coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cTn cytokine Cytokine storm elevated Endothelium Evidence evidence of hypercoagulable hyperinflammatory state Hypoxemia include Injury mechanism mechanism of injury microangiopathy Myocardial infarction myocardial injury myocarditis Myocardium pathological mechanism Patient Prognostic factor prothrombotic state serum significantly subsequent suggested susceptibility utility Viral viral invasion while [DOI] 10.2217/fca-2021-0054 PMC 바로가기 [Article Type] Review