The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19INVENT COVID 시험: COVID-19에 의해 유발된 급성 호흡곤란 증후군이 있는 피험자를 대상으로 정맥 이마티닙 메실레이트(Impentri®)의 효능과 안전성을 조사하는 무작위 대조 시험을 위한 구조화된 프로토콜Study Protocol Published on 2022-02-162022-09-10 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] 1:1 28-day mortality acute respiratory distress acute respiratory distress syndrome Admission ARDS Berlin criteria bis in die Chain Reaction changes in characterized clinical trial coronavirus disease Coronavirus disease 2019 COVID COVID-19 death decrease demonstrated discharge disease severity double-blind edema Efficacy and safety endothelial Endothelial dysfunction Estimated Extravascular lung water hypoxemic Hypoxemic respiratory failure ICU Imatinib imatinib mesylate immune response include increase in index Inflammation inflammatory conditions inhibitor intensive care intensive care unit intravenous Invasive mechanical ventilation IV infusion Kinase inhibitor life-threatening lung Lungs mechanical ventilation mechanically ventilated mesylate moderate-severe Mortality multicenter Older outcome Oxygenation pandemic parallel-group parameter parameters participant pharmacokinetics Placebo placebo-controlled polymerase chain polymerase chain reaction positive Prevent protocol Pulmonary edema randomization Randomized Randomized controlled trial recruitment reduce reduction in reflected respiratory distress Respiratory failure SARS-CoV2 secondary study period subject syndrome therapy Tolerability Trial registration tyrosine tyrosine kinase inhibitor Vascular vascular permeability Ventilation ventilator-free day Ventilator-free days water widespread [DOI] 10.1186/s13063-022-06055-9 PMC 바로가기 [Article Type] Study Protocol
Development of computer-aided model to differentiate COVID-19 from pulmonary edema in lung CT scan: EDECOVID-net폐 CT 스캔에서 코로나19와 폐부종을 구별하는 컴퓨터 지원 모델 개발: EDECOVID-netArticle Published on 2022-02-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy acetazolamide addition Administered Algorithm automatically benefit breathing carbon dioxide Computer-aided detection system (CADs) Consequences COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom COVID-19 symptoms CT images detection system development diagnosing early stages edema effort Features Hypotension knowledge Lung CT lung CT scan Lung CT scans machine machine learning matching mathematical Patient Perfusion Prevent pulmonary Pulmonary edema risk spread of COVID-19 systemic hypotension systemically the patient Transport treat Ventilation with COVID-19 Work of breathing worsening [DOI] 10.1016/j.compbiomed.2021.105172 PMC 바로가기 [Article Type] Article
Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via FerroptosisResearch Article Published on 2022-01-182022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACSL4 coronavirus Coronaviruses death Encephalitis enterovirus family FDA-approved drugs Ferroptosis Formation genome-wide CRISPR screen genome-wide CRISPR screens Host in viral indicated induce Infection inhibitor inhibitors involved mechanism member Meningitis MOST myocarditis neurological organelle pathway poliomyelitis programmed cell death Pulmonary edema Replication severe complications Synthetase viral infection Viral load [DOI] 10.1128/mbio.02717-21 PMC 바로가기 [Article Type] Research Article
Noninvasive respiratory support for COVID-19 patients: when, for whom, and how?Review Published on 2022-01-152022-10-30 Journal: Journal of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress syndrome (ARDS) Acute respiratory failure (ARF) addition advanced disease Algorithm Analysis Continuous positive airway pressure (CPAP) contraindication COPD COVID-19 COVID-19 patient COVID-19 patients CPAP disease Effect etiology H1N1 HCW healthcare worker HFNC High flow nasal cannula (HFNC) Hypoxemic respiratory failure IMV include indication intubation Invasive mechanical ventilation Invasive mechanical ventilation (IMV) lung MERS mild respiratory mortality rate NIRS NIV noninvasive respiratory Noninvasive respiratory support (NIRS) Noninvasive ventilation (NIV) outcome outcomes Pandemics Patient patient selection Potential treatment predictor Protective Pulmonary edema question recommendations reduce Research resource Respiratory failure Respiratory mechanics Respiratory Support risk SARS Self-Inflicted Lung Injury severe COVID-19 supplementary material Support Ventilation ventilator virus worsening [DOI] 10.1186/s40560-021-00593-1 PMC 바로가기 [Article Type] Review
A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infectionResearch Article Published on 2022-01-072022-11-01 Journal: Science Advances [Category] COVID-19, [키워드] acute respiratory illness acute respiratory syndrome animal model BALB/c mice C57BL/6 caused characterized coronavirus description Diffuse alveolar damage Eosinophilic European immune response immunization immunopathology Infection Lineage mice Neutralizing antibodies neutralizing antibody pathogenesis of SARS-CoV-2 Pulmonary edema Recombinant spike protein Respiratory disease SARS-CoV-2 SARS-COV-2 infection T helper cell the disease Vaccine development vaccine-associated enhanced disease [DOI] 10.1126/sciadv.abh3827 PMC 바로가기 [Article Type] Research Article
Vasculopathy in COVID-19Research article Published on 2022-01-052022-10-05 Journal: Blood [Category] COVID19(2023년), SARS, 바이오마커, [키워드] activated acute respiratory syndrome addressed Affect arise Biomarker change changes in Complication complications of COVID-19 consequence coronavirus COVID-19 dysfunction Effect endothelial Endothelial cell Endothelium help infect Infection Inflammation Inflammatory information molecular organ system outcomes Pathogenesis pathway phenotype predict prothrombotic Pulmonary edema receptor Respiratory illness response SARS-CoV-2 SARS-COV-2 infection severe respiratory disease Therapeutic approach therapy thrombosis unique Vascular vascular beds vasculature Vasculopathy virus with COVID-19 [DOI] 10.1182/blood.2021012250 [Article Type] Research article
Effect of the COVID-19 pandemic on complications and mortality of patients with cardiac surgeryReview Published on 2021-12-312022-10-30 Journal: Journal of Cardiothoracic Surgery [Category] COVID-19, SARS, [키워드] Admission affected age aortic dissection baseline biochemical cardiac function cardiovascular disease caused changes in Complication complications control group COVID-19 pandemic Critically ill patient death demonstrated disease Effect enrolled exhibited Factor Factors family Follow-up hospital Hospitalization ICU infected patients IQR median men Mortality mortality rate objective observation Patient patient population patients postoperative Prognosis Pulmonary edema Result retained risk factor ROC analysis severity Severity of disease significant decrease significant increase significantly increased survival analysis valvular women [DOI] 10.1186/s13019-021-01744-z PMC 바로가기 [Article Type] Review
Pulmonary Edema in COVID-19 Treated with Furosemide and Negative Fluid Balance (NEGBAL): A Different and Promising ApproachArticle Published on 2021-11-282022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] “cytokine storm” Acute myocardial infarction Admission Analysis angiotensin-converting enzyme 2 approach balance Blood Chest correlation COVID-19 COVID-19 patient critically ill patients decrease demonstrated diuretic edema Evidence furosemide increase Laboratory mechanical ventilation negative NEGBAL pathophysiological Patient patients died promote pulmonary Pulmonary edema required Respiratory failure SARS-CoV2 Sepsis several limitations standard treatment statistically significant tomography Trigger vena Volume volume overload [DOI] 10.3390/jcm10235599 PMC 바로가기 [Article Type] Article
Immunomodulation and Regenerative Capacity of MSCs for Long-COVIDLong-COVID에 대한 MSC의 면역 조절 및 재생 능력Review Published on 2021-11-172022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ARDS Capacity clinical clinical trial clinical trials Cytokine storm death edema Effect effective drug effective drugs eventually death immunomodulation immunomodulator include Inflammation long-COVID lung lung injuries Lung injury mesenchymal stem cell Mesenchymal stem cells MSC MSCs Mutation patients with COVID-19 Post-COVID-19 patients promote provided Pulmonary edema reduce regeneration regenerative regenerative properties respiratory distress SARS-CoV-2 virus severity syndrome the disease the SARS-CoV-2 virus therapy Treatment Trial Usage [DOI] 10.3390/ijms222212421 PMC 바로가기 [Article Type] Review
Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDSResearch Published on 2021-11-152022-11-01 Journal: Critical Care [Category] COVID-19, MERS, 신종인플루엔자, [키워드] alteration Amino acid Analysis analyzed ARDS Biomarker cause characteristic characterized Conference Coronavirus disease 2019 COVID-19 COVID‐19 defined Diagnosis distress etiologies Glycolysis groups H1N1 influenza identify induce Inflammatory intensive care involved lipid metabolism Lung inflammation maintain management metabolic pathway metabolism metabolomic metabolomics multivariate NMR noradrenaline oxidative stress pathway Pathways Patient patients with ARDS patients with COVID-19 Pneumonia Prognosis Pulmonary edema Regulation resonance Respiratory failure responses Result serum sample severe cases specificity Spectroscopy supplementary material Support syndrome was performed were used [DOI] 10.1186/s13054-021-03810-3 PMC 바로가기 [Article Type] Research