Synthesis and antimalarial and anticancer evaluation of 7-chlorquinoline-4-thiazoleacetic derivatives containing aryl hydrazide moietiesarticle Published on 2021-07-312024-09-01 Journal: Archiv der Pharmazie [Category] 말라리아, [키워드] antimalarial antiproliferative Apoptosis hydrazides quinoline thiazol [Article Type] article
Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analoguesArticle Published on 2021-07-012023-07-01 Journal: Antiviral Research [Category] SARS, [키워드] Antiviral Chloroquine coronavirus COVID-19 quinoline [DOI] 10.1016/j.antiviral.2021.105127 PMC 바로가기 [Article Type] Article
New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2Article Published on 2021-06-232023-07-01 Journal: Bioorganic chemistry [Category] SARS, [키워드] click chemistry molecular docking quinoline SARS-CoV-2 triazole [DOI] 10.1016/j.bioorg.2021.105117 PMC 바로가기 [Article Type] Article
Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitorsarticle Published on 2021-01-312024-09-01 Journal: European Journal of Medicinal Chemistry [Category] 말라리아, [키워드] malaria P. falciparum PfDHODH Pyrazolopyrimidine quinoline triazolopyrimidine [Article Type] article
Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ Analogues바이러스 감염 중 MAPK 캐스케이드에 대한 분자적 통찰력: HCQ와 HCQ 유사체 간의 잠재적인 누화Review Published on 2020-12-312022-09-10 Journal: BioMed Research International [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus analogue analogues antimalarial approach approved attacks cascade cause claimed Combination coronavirus country COVID-19 COVID-19 pandemic Critical Crosstalk deaths Defense disease Diseases drugs Efficacy Extracellular HCQ highlight Host host defense Hydroxychloroquine in viral indicated Infection inhibitor insight MAPK mechanism mitogen mitogen-activated protein kinase molecular mechanisms molecular pattern molecular patterns Pandemics pathway Potential Protein quinoline receptor respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Transcription transducing Treatment variety Viral viral infection viral infections Virus Disease [DOI] 10.1155/2020/8827752 PMC 바로가기 [Article Type] Review
Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Applicationarticle Published on 2020-12-312024-09-01 Journal: Current Topics in Medicinal Chemistry [Category] 말라리아, [키워드] Antiplasmodial activity Chloroquine cytotoxicity P. falciparum quinoline β-HI activity. [Article Type] article
Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 InfectionCOVID-19 감염 상황에서 클로로퀸과 하이드록시클로로퀸의 약동학 및 약리학적 특성Review Published on 2020-12-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] SARS, 말라리아, 임상, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome addition administration approved Azithromycin Chloroquine Clinical efficacy clinical pharmacology Clinical studies clinical study Combination Context coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 derivative effective Effectiveness Evidence healthy Hydroxychloroquine information malaria mechanism mechanism of action medication Patient Pediatric patient Pediatric patients pharmacokinetics Planning property Prophylaxis provide quinoline Randomized respiratory distress severe acute respiratory distress syndrome Support syndrome treat Treatment Viral viral infections [DOI] 10.1002/cpt.1993 PMC 바로가기 [Article Type] Review
Could Respiratory Fluoroquinolones, Levofloxacin and Moxifloxacin, Prove to be Beneficial as an Adjunct Treatment in COVID-19?호흡기 플루오로퀴놀론, 레보플록사신 및 목시플록사신이 COVID-19의 보조 치료제로 유용할 수 있습니까?Article Published on 2020-10-012022-09-11 Journal: Archives of medical research [Category] SARS, 신약개발, 치료제, [키워드] adjunct adjuncts anti-inflammatory drug Anti-inflammatory drugs Antibiotics antimicrobial agents antiretroviral drug Antiviral antiviral action antiviral activity attenuation binding broad spectrum characterized Chloroquine ciprofloxacin CMV community-acquired pneumonia comparable Concentration COVID-19 COVID-19 pandemic Cytokines derivative effective therapy exhibiting Fluoroquinolone HCV HIV HSV-1 immunomodulatory immunomodulatory properties in silico Infection Inflammatory response inhibit SARS-CoV-2 levofloxacin Lungs management moxifloxacin nelfinavir papovavirus pharmacokinetic Pneumonia pro-inflammatory cytokines prodrome protease Protease inhibitor quinoline Replication researcher respiratory respiratory infections safety profile SARS-CoV-2 SARS-CoV-2 replication shown therapeutic agent therapeutic agents treat Treatment vaccinia virus [DOI] 10.1016/j.arcmed.2020.06.004 PMC 바로가기 [Article Type] Article
New hybrid trifluoromethylquinolines as antiplasmodium agentsArticle Published on 2019-03-152024-08-28 Journal: Bioorganic & Medicinal Chemistry [Category] 말라리아, [키워드] amodiaquine hybrids malaria mefloquine P. falciparum quinoline
Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylateArticle Published on 2018-02-152024-08-27 Journal: Bioorganic & Medicinal Chemistry [Category] 말라리아, [키워드] Cancer Chloroquine leukemia malaria quinoline