Recombinant VLPs empower RBM peptides showing no immunogenicity in native SARS-COV-2 protein to elicit a robust neutralizing antibody response재조합 VLP는 천연 SARS-COV-2 단백질에서 면역원성을 나타내지 않는 RBM 펩타이드를 강화하여 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-04-012022-09-11 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Antigen antigenicity Antisera candidate carrier protein core antigen coronavirus demonstrated effective delivery elicit epitope Epitopes HBcAg immunization in vitro inactivated indicate KLH linear mice motif Multi-epitope vaccine Neutralizing activity neutralizing antibody Neutralizing antibody response New overlapping Particle peptide peptide epitope peptides Protein RBM reactivity receptor binding motif receptor-binding motif Receptor-binding motif (RBM) recombinant respiratory robust S1 protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Vaccine variants virus virus infection virus mutation Virus-like particle virus-like particles Virus-like particles (VLPs) VLP VLPs [DOI] 10.1016/j.nano.2022.102527 PMC 바로가기 [Article Type] Article
Combined Subcutaneous-Intranasal Immunization With Epitope-Based Antigens Elicits Binding and Neutralizing Antibody Responses in Serum and Mucosae Against PRRSV-2 and SARS-CoV-2에피토프 기반 항원과 결합된 피하-비강내 면역화는 PRRSV-2 및 SARS-CoV-2에 대한 혈청 및 점막의 결합 및 중화 항체 반응을 유도합니다Article Published on 2022-03-312022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Administered Against animal antibodies antibody Antigen antigens Antiviral approaches asymptomatic infection baculovirus binding binding antibody Combination Combined Concentration conserved elicit emerging and re-emerging viruses envelope protein epitope epitope-based antigens evaluate evaluated expressed fluids generate GP5 Humoral response immunization immunization strategy immunized induce Infection inhibited inoculated Interaction intranasal intranasally investigated Local memory response mucosal mucosal antibodies Mucosal immunization nasal Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody New Prevent produced promoted Protein RBD-ACE2 receptor-binding motif recombinant baculovirus recombinant proteins recombinant proteins. reduce response responses SARS-CoV-2 serum serum antibody serum sample subcutaneously the S protein Transmission vaccinated individuals Vaccine design vaginal swabs virus [DOI] 10.3389/fimmu.2022.848054 PMC 바로가기 [Article Type] Article
Improved Binding Affinity of Omicron’s Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence인간 안지오텐신 전환 효소 2 수용체에 대한 오미크론 스파이크 단백질의 향상된 결합 친화도는 독성 증가의 핵심입니다Article Published on 2022-03-212022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Amino acid amino acid residue amino acids angiotensin Antiviral agents binding binding free energies binding free energy characterized complex contribute coronavirus country D38 domain electrostatic interaction enzyme exhibited free energy genomic region hACE2 hACE2 receptor Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human angiotensin-converting enzyme 2 (hACE2) hydrogen hydrogen bonding Improved Increased information Interaction investigated mode molecular molecular dynamics Molecular dynamics simulation Molecular mechanics molecular mechanics-generalized Born surface area (MM-GBSA) mutated Mutation omicron Omicron variant Other pi-stacking RBD receptor Receptor-binding domain Receptor-binding domain (RBD) receptor-binding motif Receptor-binding motif (RBM) residue resulting salt bridges SARS-CoV-2 SARS-CoV-2 RBD Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) spike Spike protein surface area the RBD the spike protein Transmissibility tyrosine variant variant of SARS-CoV-2 virus wild type [DOI] 10.3390/ijms23063409 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responsesArticle Published on 2022-02-032022-10-31 Journal: Cell [Category] COVID-19, [키워드] Abstract ACE2 ACE2 binding ACE2 binding site ameliorated Analysis antibody Beta binding Booster vaccine change changes in comprehensive analysis convalescent convalescent patient COVID-19 pandemic Delta driven by Evolution facilitate failure Gamma Immune escape immune evasion mAb monoclonal antibody Mutation neutralization neutralization titers neutralize Neutralizing antibody response new SARS-CoV-2 omicron pandemic RBD receptor receptor interaction receptor-binding motif reduce reduced reduction in reported reveal SARS-CoV-2 selective sequence sera spike subject the SARS-CoV-2 titer vaccinated individual vaccine dose vaccinee vaccinees Vaccines variant variants virus viruses widespread [DOI] 10.1016/j.cell.2021.12.046 PMC 바로가기 [Article Type] Article
Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 교차 변형 중화 사이트 매핑Coronaviruses Published on 2022-01-242022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses antibody approved B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 bind binding biochemical Combination comparable conserved coronavirus cryo-EM decrease effective vaccine Efficacy epitope Epitopes evaluate exhibit exhibits Guidance identify loop mAbs mapping monoclonal antibodies monoclonal antibody neutralization neutralize Neutralizing potency pseudoviruses raised RBD Receptor-binding domain receptor-binding motif respiratory SARS-CoV-2 SARS-CoV-2 spike protein SD1 significantly Spike protein target tested the receptor-binding domain the SARS-CoV-2 the spike protein therapeutic Therapies Vaccine variant variants variants of concern Virological [DOI] 10.1080/22221751.2021.2024455 PMC 바로가기 [Article Type] Coronaviruses
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift Research Published on 2022-01-112022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 amino acid substitution antigenic antigenic site bind conserved convalescent individual dose Effectiveness ENCODE epitope fraction human ACE2 immune evasion in vitro individual less magnitude monoclonal antibody MOST neutralized Neutralizing Neutralizing activity neutralizing antibody neutralizing monoclonal antibody omicron overcome pandemic plasma pseudovirus raising RBD receptor-binding motif recognize reductions in sarbecovirus SARS-CoV-2 SARS-CoV-2 variant the receptor-binding domain the spike protein Vaccine variant Wuhan-Hu-1 zoonotic [DOI] 10.1038/s41586-021-04386-2 [Article Type] Research
A SARS-CoV-2 Delta Variant Case Manifesting as Extensive Placental Infection and Fetal TransmissionArticle Published on 2022-01-012022-11-15 Journal: Gynecologic and obstetric investigation [Category] SARS, 변종, 치료기술, [키워드] analyzed Apoptosis B.1.167.2 Cell COVID-19 Delta delta variant determine dominant exhibited Extensive Ferroptosis fetal fixed higher infectivity Infection membrane membranes mother Mutation Necrosis Placenta placental Placental infection placental tissue positive Pregnancy Premature Probability receptor-binding motif rupture SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection Spike protein tested Transmission umbilical variant Vascular endothelium vertical transmission Viral RNA with COVID-19 [DOI] 10.1159/000524905 PMC 바로가기
A scalable and highly immunogenic virus-like particle-based vaccine against SARS-CoV-2SARS-CoV-2에 대한 확장 가능하고 면역원성이 높은 바이러스 유사 입자 기반 백신Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] added addition antibody Antibody Response Antibody responses Bacterial booster booster injections candidate vaccine caused centrifugation classical convalescent COVID-19 cross-reactive dose effective hand human sera hygiene immunogenic immunologically in some induce Injections long term Masks mice mutant Neutralizing Pandemics purification RBD RBM receptor-binding motif RNA SARS-CoV-2 stability the SARS-CoV-2 the vaccine Vaccine vaccine candidate Vaccines variants variants of concern virus virus-like particles wearing masks while yield [DOI] 10.1111/all.15080 PMC 바로가기 [Article Type] Article
The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviourCommunications Published on 2021-12-112022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract ACE2, angiotensin-converting 2 enzyme Affect Alter binding binding pocket binding site CD, connector domain CH, central helix change conformational Contact D614G FA, fatty acid fatty FP, fusion peptide FPPR, fusion-peptide proximal region functional furin cleavage site Genetic variation host cell HR1, heptad repeat 1 human ACE2 receptor identify LA, linoleic acid Ligand MD, molecular dynamics membrane fusion MERS, Middle East respiratory syndrome modulate Molecular dynamics simulation motif mutant Mutation NTD, N-terminal domain Protein RBD, receptor binding domain RBM, receptor-binding motif receptor-binding motif Region regions removal RMB, receptor binding motif SARS-CoV-2 spike protein SARS-CoV-2, severe acute respiratory syndrome 2 SARS, Severe acute respiratory syndrome Science significantly Simulation Spike protein the SARS-CoV-2 the SARS-CoV-2 virus transmitted variant [DOI] 10.1016/j.csbj.2021.12.011 PMC 바로가기 [Article Type] Communications
Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms백신 접종 전 단계에서 멕시코에서 SARS-CoV-2의 계통유전체학 및 인구유전체학은 관심 변이 B.1.1.28.4 및 B.1.1.222 또는 B.1.1.519 및 증상과 관련된 뉴클레오캡시드 돌연변이 S194L을 나타냅니다Research Articles Published on 2021-11-302022-09-10 Journal: Microbial Genomics [Category] MERS, SARS, 변종, 치료기술, 치료법, [키워드] adaptive addition allelic Analysis Asymptomatic Asymptomatic carriers baseline carrier clades Clinical data complementary COVID-19 pandemic disease dual E484K Effect Evolution Evolution of SARS-CoV-2 fixed Follow-up Frequency Genetic Genome genomes help highlight Host lack Mexico mitigate Mutation N-terminal domain nucleocapsid nucleocapsid protein Nucleocapsid proteins nucleotide pandemic phenotypic Phylogenomics population genomics pre-vaccination Prevalence Protein quantitative PCR raising receptor-binding motif Region reveal SARS-CoV-2 SARS-CoV-2 virus Single nucleotide variant single nucleotide variants spike and nucleocapsid proteins spike glycoprotein Spike protein Symptom symptomatic and asymptomatic Symptomatic patients T478K the SARS-CoV-2 virus understanding vaccination variant variants variants of interest virus [DOI] 10.1099/mgen.0.000684 PMC 바로가기 [Article Type] Research Articles