Molecular Docking and In-Silico Analysis of Natural Biomolecules against Dengue, Ebola, Zika, SARS-CoV-2 Variants of Concern and Monkeypox VirusArticle Published on 2022-09-222022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, 치료제, [키워드] Amino acid AMP AMPs antimicrobial peptide Antiviral antiviral drug Antiviral treatment AutoDock vina B.1.617.2 Bacterial bacterial AMPs binding energy Biomolecule biomolecules Cell cell receptor cell surface receptors concern Control Dengue dengue virus determine develop docking docking score Ebola Ebola virus Effective vaccines envelope protein Evolution in silico increase in indicated Modification molecular molecular docking Monkeypox monkeypox. mutant natural Occurrence P.1 pathogenic viruses positive proline Protein receptors SARS-CoV-2 Secondary Metabolite specific neutralizing antibody tested the SARS-CoV-2 the spike protein therapeutic agents variant variants of SARS-CoV-2 viral cell viral surface virus virus was performed Zika Zika virus [DOI] 10.3390/ijms231911131 PMC 바로가기
A study protocol for a double-blind randomised placebo-controlled trial evaluating the efficacy of carrageenan nasal and throat spray for COVID-19 prophylaxis-ICE-COVIDArticle Published on 2022-09-152022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] 1:1 applied carrageenan clinical trial COVID-19 COVID-19 infection COVID-19. demonstrated double-blind double-blinded Effect effective Efficacy expressed General population host cell surface host cells in vitro activity include Infection infections initial viral load iota-carrageenan kappa-carrageenan nasal Non-COVID-19 nose and throat occur outcome participant penetrate Placebo placebo-controlled placebo-controlled clinical trial placebo-controlled trial polysaccharide positive PCR Prophylactic Prophylaxis purified questionnaire randomised receptors reduce Research risk SARS-CoV-2 secondary Seroconversion severity severity of COVID-19 shown Sodium chloride Study protocol subsequent Swab Symptom symptom onset thought treatment arm Trial upper respiratory tract utility vaccination Vaccine variant viral entry virus [DOI] 10.1186/s13063-022-06685-z PMC 바로가기
Photochemical Identification of Auxiliary Severe Acute Respiratory Syndrome Coronavirus 2 Host Entry Factors Using μMapArticle Published on 2022-09-142022-11-16 Journal: Journal of the American Chemical Society [Category] SARS, 변종, [키워드] ACE2 ACE2 expression acute respiratory syndrome auxiliary cell entry complex coronavirus coronavirus 2 COVID-19 pandemic Critical Delta eight engage ENhance enzyme expression facilitate Factor Genetic Host human cell identification identify identifying labeling lymphocyte membrane fusion pathophysiology platform powerful tool Protein receptor receptors respiratory SARS-CoV-2 significantly spike variant systemically the spike protein tissues transmembrane serine protease viral entry Wuhan [DOI] 10.1021/jacs.2c06806 PMC 바로가기
The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
The regulation of ISG20 expression on SARS-CoV-2 infection in cancer patients and healthy individualsArticle Published on 2022-09-132022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] analyzed anti-SARS-CoV-2 anticancer Bone marrow Cancer cancer cell cancer cell lines cancer patient Cancer patients chemokine combating cordycepin cordycepin (CD). correlated COVID-19 COVID-19 pandemic domain exhibited expression functional healthy healthy individual highest immune Immune cell infiltration immune infiltration individuals information inhibit Invasion ISG20 ISG20 expression isoform less Lymphocytes lymphoid tissues marker Methylation MHC molecule mRNA expression mutant N6 N6-dimethyladenosine (m 6 2A) outcome overexpression promoter receptors Regulation SARS-CoV-2 SARS-COV-2 infection significantly significantly increased significantly lower small molecule survival survival rate susceptibility the median therapeutic potential tissue tissues traditional Chinese medicines treat tumorigenesis underlie virus were used [DOI] 10.3389/fimmu.2022.958898 PMC 바로가기
Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methodsArticle Published on 2022-09-022022-11-16 Journal: Medicine [Category] SARS, 유전자 메커니즘, [키워드] A549 cell activated Activation acute respiratory syndrome addition Analysis Atypical candidate caused characterized CLC complications CoV COVID COVID-19 COVID-19 infection cytokine deaths DEGs Determining differentially expressed gene disease drug effective experimental validation Gene Expression Omnibus gene signatures Genomics GEO GSE147507 human-to-human transmission identify IFNβ IL-17 IL-1β Illumina in silico In silico method influenza A Interaction interferon beta interferon regulatory factor IRF3 IRF9 JQ1 knowledge mechanism Methylprednisolone mock-treated pathology pathway Pneumonia Prednisolone Quality control receptors RNA RNA sequencing RNA sequencing data SARS CoV-2 signaling pathway signaling pathways small molecule STAT2 the Coronaviridae the disease therapy Transcription Treatment underlying disease upstream Viral protein virus infection was used with COVID-19 Wuhan, China [DOI] 10.1097/MD.0000000000029554 PMC 바로가기
Treatment of COVID-19-induced refractory status epilepticus by tocilizumab토실리주맙에 의한 COVID-19 유발 불응성 간질 지속 상태의 치료Case Reports Published on 2022-09-012022-09-12 Journal: European journal of neurology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome block caused coronavirus correlated COVID-19 COVID-19 infection disease IL-6 IL-6 inhibitor immune system increasingly Infection Infectious disease inhibitor of IL-6 interleukin 6 nervous system Neurological complication Patient receptors reported SARS-CoV-2 Seizure Seizures severity of symptoms Signal transduction status epilepticus symptomatic the cytokine storm Tocilizumab tocilizumab. Treatment treatment with tocilizumab Unverricht-Lundborg disease [DOI] 10.1111/ene.15440 PMC 바로가기 [Article Type] Case Reports
Mechanisms of COVID-19 pathogenesis in diabetes당뇨병에서 COVID-19 발병 기전의 메커니즘Review Published on 2022-09-012022-09-11 Journal: American journal of physiology. Heart and circulat [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 cardiovascular cardiovascular disease caused Comorbidities coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pathogenesis Cytokine storm diabete diabetes Disease progression Effect enzyme global pandemic heart failure Host host cell host cells hypertension Inflammation Inflammation. mechanism multiorgan failure Mutation outcomes Patient receptor receptors resulting risk of infection SARS-CoV-2 SARS-CoV-2 spike proteins severe acute respiratory syndrome Coronavirus therapeutic approaches variety virus [DOI] 10.1152/ajpheart.00204.2022 PMC 바로가기 [Article Type] Review
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors Toll-like receptors. understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
In silico evaluation of food-derived carotenoids against SARS-CoV-2 drug targets: Crocin is a promising dietary supplement candidate for COVID-19Article Published on 2022-09-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ADP-ribose antioxidant B.1.351 binding affinity binding energy carotenoid carotenoids clinical trial complex component COVID-19 COVID-19 pandemic crocin dietary supplement dietary supplement candidates docking experiment docking result drug target effective exhibited Favipiravir food-derived carotenoids globe Healthcare system Helicase in silico inhibitors inhibitory effect Inhibitory effects Ivermectin Lineage molecular molecular docking Molecular dynamics simulation multitarget inhibitors. mutant mutant spike protein performed phosphatase Preliminary data Prophylaxis protease provide receptor receptors Remdesivir Replication SARS-CoV-2 SARS-CoV-2 drug Spike protein stability suggested target target protein tested therapy Treatment variants of concern [DOI] 10.1111/jfbc.14219 PMC 바로가기