Deep transfer learning for the recognition of types of face masks as a core measure to prevent the transmission of COVID-19Research article Published on 2022-08-012022-10-05 Journal: Applied Soft Computing [Category] 치료기술, [키워드] Accuracy appear caused COVID-19 deep deep learning detection system effective Experimental result Face mask Face masks highest Infection lowest measure Prevent Recognition spread of COVID-19 surgical transfer transfer learning Transmission virus virus transmission [DOI] 10.1016/j.asoc.2022.109207 [Article Type] Research article
Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infectionOmicron BA.1 돌발성 감염 후 기존 교차 반응성 B 세포 기억 회상Article Published on 2022-07-292022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody Response B cell B cell memory B cell response Breakthrough infection characterized conserved coronavirus cross-reactive Donor donors facilitate feature Heterologous immune response immune responses immunodominance Infection memory B cells Messenger RNA Neutralizing antibodies neutralizing antibody omicron Preexisting immunity proportion RBD Receptor binding domain Recognition respiratory S2 subunit SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shift understanding Vaccines VOCs [DOI] 10.1126/sciimmunol.abq3511 PMC 바로가기 [Article Type] Article
Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition억제되지 않은 HIV 감염은 SARS-CoV-2 감염에 대한 T 세포 반응을 손상시키고 T 세포 교차 인식을 폐지합니다Article Published on 2022-07-262022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] abrogate abrogation Beta Beta variant CD4 CD8 correlated COVID-19 disease COVID-19 epidemic Cytometry determine diminishe epitope epitope specificity explain First wave Flow flow cytometry greater highlight HIV HIV infection Human identify immunodominance immunology impair in some individual Infection Inflammation instances mechanism mononuclear cell Mutation peptide peptide pools Peripheral blood PLWH Protein Recognition SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants second wave severe COVID-19 severe COVID-19 disease significantly South Africa specificity Spike protein susceptibility T cell T cell activation T cell response T cell responses the Spike variant was used with HIV [DOI] 10.7554/eLife.78374 PMC 바로가기 [Article Type] Article
Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution바이러스 진화 중 SARS-CoV-2 수용체 결합 도메인의 돌연변이 제약 조건 이동Article Published on 2022-07-222022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus Affect Alpha Amino acid angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Beta coronavirus Delta domain Effect epistasis Eta Evolution example facilitate Interpretation modulating Mutation N501Y occur omicron performed phenomenon RBD RBDs receptor Recognition respiratory SARS-CoV-2 SARS-CoV-2 evolution severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike receptor-binding domain subsequent Substitution substitutions the SARS-CoV-2 variant variants viral evolution Wuhan-Hu-1 [DOI] 10.1126/science.abo7896 PMC 바로가기 [Article Type] Article
Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibodySpike S2 도메인 특이적 인간 중화 단일클론 항체의 직접적인 호흡기 투여에 의해 매개되는 강력한 보편적인 베타-코로나바이러스 치료 활성Article Published on 2022-07-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta acute respiratory syndrome acute respiratory syndrome coronavirus-2 Administered administration antibody Beta beta-coronavirus check conserved convalescent coronavirus coronavirus vaccine Delta demonstrated determine dose Epsilon Gamma hACE2 hamster hamsters Human human monoclonal antibodies Human monoclonal antibody IgG Immune escape in vivo infected with SARS-CoV-2 Infection infection with SARS-CoV-2 intranasal K18 Lineage mAb mAbs MERS-CoV mice monoclonal antibody Mortality Mutation neutralize SARS-CoV neutralized Neutralizing omicron plasma potent pre-fusion Prevent Prophylactic Recognition recognize reduced respiratory respiratory viral S1 and S2 S2 domain SARS-CoV Urbani SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 spike screened Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 significantly spike subject subjects tested therapeutic activity therapeutic potential Vaccine variants of concern Viral virus weight loss β-coronavirus [DOI] 10.1371/journal.ppat.1010691 PMC 바로가기 [Article Type] Article
Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19심장대사 바이오마커의 단백질체 분석 및 COVID-19로 입원한 환자의 심각한 결과 예측 모델링Article Published on 2022-07-212022-09-11 Journal: Cardiovascular Diabetology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerate ACE2 ADAMTS13 Admission Analysis association Biomarker Biomarkers cardiometabolic Cardiometabolic biomarkers cardiometabolic disease Care circulating Clinical data collected Comorbidity COVID-19 COVID-19 severity death First wave heterogeneity high-risk patient High-risk patients higher risk identify IL-1ra IL6 implicated intensive care intensive care unit likelihood lower risk outcome outcomes pandemic Patient patients patients hospitalized performed plasma sample plasma samples predict Predictive Predictive model Predictive modeling predictive models Protein proteomic Proteomic analysis proteomics Recognition Risk factors Seven severe COVID-19 severity severity of COVID-19 shown susceptible Symptom the disease Treatment VEGFD with COVID-19 [DOI] 10.1186/s12933-022-01569-7 PMC 바로가기 [Article Type] Article
An Electrostatically-steered Conformational Selection Mechanism Promotes SARS-CoV-2 Spike Protein Variation정전기로 조종되는 구조적 선택 메커니즘은 SARS-CoV-2 스파이크 단백질 변이를 촉진합니다Article Published on 2022-07-152022-09-11 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 amino acids Analysis analyzed collected conformational conformational change conformational changes COVID-19 COVID-19 pandemic Critical Cross-species transmission epidemiological epidemiological surveillance Evolution fusion global public health global public health emergency HADDOCK heterogeneity host cell host cell receptor hydrophobicity identify immune evasion IMPROVE local interaction local interactions MOST outbreak promote Protein protein–protein interactions Recognition recorded reducing Region replacing risk S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Selection sequence variation spike Substitution substitutions Surveillance the S protein trimer vaccination Vaccine development variant [DOI] 10.1016/j.jmb.2022.167637 PMC 바로가기 [Article Type] Article
Development of COVID-19 therapies: Nonclinical testing considerationsCOVID-19 치료법 개발: 비임상 테스트 고려 사항Article Published on 2022-07-012022-09-12 Journal: Regulatory toxicology and pharmacology : RTP [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료제, [키워드] agency antibody authorization Candidates COVID-19 development Emergency EUA mAb monoclonal monoclonal antibody neutralization Nonclinical occurred pathway Patient performed pharmacokinetic platform Recognition reduced Regulatory Result SARS-CoV-2 small molecule Small molecules the spike protein therapy Toxicity Treatment USA utility vaccination Vaccine Vaccines [DOI] 10.1016/j.yrtph.2022.105189 PMC 바로가기 [Article Type] Article
Mobile sensors based platform of Human Physical Activities Recognition for COVID-19 spread minimizationResearch article Published on 2022-07-012022-10-05 Journal: Computers in biology and medicine [Category] 치료기술, [키워드] accelerometer Accuracy activities activity Activity classification activity recognition Classifier collected computation concerning Contact tracing continuous monitoring COVID-19 COVID-19 pandemic dataset determine Diseases effective Effectiveness evaluate EWS feature GPS Gyroscope highest Human human behavior Infection infection risk Long Mobile pandemic platform prevalent Probability random Recognition recognize Research risk smartphone sensors Spread Support System tracing [DOI] 10.1016/j.compbiomed.2022.105662 [Article Type] Research article
T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article