Significant changes in follicular fluid phthalate metabolite levels reflect the lifestyle changes brought about by the strict COVID-19 lockdown in IndiaResearch article Published on 2022-08-012022-10-05 Journal: F&S science [Category] 유전자 메커니즘, [키워드] absence accumulated age analyzed BMI Care change changes in collected contributed coronavirus COVID-19 COVID-19 lockdown COVID-19 pandemic decrease Defense detect dibutyl phthalate Effect endocrine-disrupting chemicals evaluate flexible Follicular fluid group hospital human behavior hygiene in vitro In vitro fertilization include increase in India initiated injection lifestyle changes lockdown median metabolite metabolites objective Oocyte Personal protective equipment phthalates processed promoted reflect responsible screened seeking setting Significant significantly higher the median Treatment women [DOI] 10.1016/j.xfss.2022.06.001 [Article Type] Research article
Neutralizing SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Give Patients with X-Linked Agammaglobulinemia Limited Passive Immunity to the Omicron VariantArticle Published on 2022-08-012022-11-15 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] agammaglobulinemia antibody appear collected Concentration COVID-19 Donor Immunity Immunoglobulin immunoglobulin replacement therapy in vitro individual infections Karolinska University Hospital Limited neutralize neutralizing capacity observation omicron original virus strain pandemic Passive passive immunity Patient plasma plasma concentration Prevent Primary Immunodeficiency product Protective reflect remained Sample SARS-CoV-2 SARS-CoV-2 antibody symptomatic the SARS-CoV-2 therapy unit variant were assessed X-linked agammaglobulinemia X-linked agammaglobulinemia. XLA [DOI] 10.1007/s10875-022-01283-9 PMC 바로가기
The impact of COVID-19 on antimicrobial stewardship programme implementation in hospitals – an exploration informed by the Consolidated Framework for Implementation ResearchResearch article Published on 2022-08-012022-10-05 Journal: The Journal of hospital infection [Category] 신약개발, 치료제, [키워드] activity analysed Antimicrobial stewardship approach ASP caused CFIR changes in conducted contributing to Coronavirus disease 2019 COVID-19 COVID-19 patient ENhance framework Healthcare system hospital hospitals Impact implementation initial management national guideline pandemic participant positive Qualitative recorded recruited reflect reported researcher respond Result Support transcribed Treatment [DOI] 10.1016/j.jhin.2022.08.005 [Article Type] Research article
Proceedings of the ISCT scientific signature series symposium, “Advances in cell and gene therapies for lung diseases and critical illnesses”: International Society for Cell & Gene Therapy, Burlington VT, US, July 16, 2021Review article Published on 2022-08-012022-10-05 Journal: Cytotherapy [Category] 비임상, [키워드] biennial bioengineering Biology Cell Cell therapy cell-based therapies Critical Critical illness European Evolution Gene therapy illness illnesses independent ISCT Lung disease Lung injury mechanism Mesenchymal stromal cell mitigate MSCs Patient preclinical data Proceeding pulmonary reflect respiratory Respiratory disease Sery signature Society state stromal cell symposium therapy thought took place transfer translated University of Vermont vectors [DOI] 10.1016/j.jcyt.2021.11.007 [Article Type] Review article
Increase in Referrals of Children and Adolescents to the Psychiatric Emergency Room Is Evident Only in the Second Year of the COVID-19 Pandemic-Evaluating 9156 Visits from 2010 through 2021 in a Single Psychiatric Emergency RoomObservational Study Published on 2022-07-222022-10-05 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] 95% CI Adolescent affected children clinically clinician COVID-19 COVID-19 pandemic Emergency growth incline increase increase in Mental pediatric pediatric mental health positive predicted previous study problems Psychiatric Psychiatric emergency psychiatric emergency room. Referral reflect representing Retrospective study rising room second Year [DOI] 10.3390/ijerph19158924 PMC 바로가기 [Article Type] Observational Study
Estimation of vaccine efficacy for variants that emerge after the placebo group is vaccinated위약군 백신 접종 후 나타나는 변이체에 대한 백신 효능 추정Article Published on 2022-07-202022-09-11 Journal: Statistics in medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] approach assumption clinical trial Cox regression demonstrated develop distribution Effects Efficacy estimation evaluate Follow-up hazard illustration misspecification Observational data Placebo placebo group Poisson proportion proportional hazards model proportions Randomized rare disease reflect SARS-CoV-2 Sensitivity analyses sensitivity analysis sieve analysis strain Strains Surveillance surveillance data the placebo group the vaccine vaccination Vaccine vaccine efficacy vaccine trial variant variants [DOI] 10.1002/sim.9405 PMC 바로가기 [Article Type] Article
Torque teno virus DNA load as a predictive marker of antibody response to a three-dose regimen of COVID-19 mRNA-based vaccine in lung transplant recipientsArticle Published on 2022-07-012022-10-05 Journal: The Journal of heart and lung transplantation : th [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] 95% confidence interval Analysis Anti-RBD IgG anti-receptor-binding domain Antibody Response Antibody titer association Biomarker BNT162b2 Characteristics COVID-19 COVID-19 vaccine cut-off develop DNA dose doses evaluate Factors Future IgG response Immunosuppression investigated LTR lung transplant lung transplantation marker mRNA vaccine mRNA-1273 mRNA-based vaccine multivariate logistic regression neutralized Neutralizing antibodies non-responders Omicron variant Patient positive Predictive previous study Ratio RBD recipient reflect regimen reported respond poorly responders ROC Curve second dose Seroconversion the antibody response torque torque teno virus Treatment vaccination Vaccine vaccine response viral DNA virus [DOI] 10.1016/j.healun.2022.07.008 [Article Type] Article
Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infectionsSARS-CoV-2 감염의 동반 질환 관련 단백질에 대한 Momordica dioica의 예측 의약 대사 산물Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 ADME angiotensin angiotensin converting enzyme antidiabetic Antiviral binding binding affinities Blood brain barrier cardiovascular disease catechin comorbid comorbid condition comorbid conditions Comorbidity Compound correlated DDP4 diabetes dipeptidyl peptidase docking score DPP4 drugs enzyme exhibited Favipiravir flavonoid flavonoids gastrointestinal tract hederagenin Human Hydroxychloroquine immune immunomodulatory activities in silico in vitro investigated involved kidney ligands metabolite molecular molecular docking Momordica Momordica dioica oleanolic acid plant predicted protease Proteases Protein quercetin RdRP receptor reflect Remdesivir reported RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 main protease significant interaction Spike protein the SARS-CoV-2 therapeutic viral entry viral proteases [DOI] 10.1080/07391102.2020.1868340 PMC 바로가기 [Article Type] Article
Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causesResearch article Published on 2022-06-242022-10-05 Journal: Heliyon [Category] 바이오마커, 치료기술, [키워드] accompanied Analysis cause CD14+ CD14+ monocyte CD8+ T cells change characteristic Cohort concentrations controls correlated COVID-19 Critical cytokine Cytokine release syndrome Disease progression disease severity expression flow cytometry greater healthy control Hypothesis immune checkpoint immune response immunometabolism involved Lipid mechanism metabolic derangement metabolic risk factor metabolism monocytopenia mononuclear cell multiplex pandemic Pathway analysis Patient PBMC PBMCs PD-L1 Peripheral blood Phosphatidylcholine plasma plasma concentration recruited reduced reflect Result Sepsis serum severe cases severity shown SOFA score Support systemic inflammatory response the disease Treg Tryptophan unique was increased was performed [DOI] 10.1016/j.heliyon.2022.e09733 [Article Type] Research article
Chasing LDL cholesterol to the bottom — PCSK9 in perspective Reviews Published on 2022-06-152022-10-05 Journal: The Pan African Medical Journal [Category] 유전자 메커니즘, [키워드] alleviate Atherosclerosis atherosclerotic cardiovascular disease cardiovascular risk combating Concentration contribute events Health Improved Intervention investigators LDL LDL cholesterol LDL-C Low-density lipoprotein Measures notable outcome PCSK9 Perspective Prevent recent reflect therapeutic therapy [DOI] 10.1038/s44161-022-00085-x [Article Type] Reviews